AGENDA

THURSDAY, NOVEMBER 20, 2014

8:30-9:00am  Registration & Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda

9:00  Opening Remarks


SESSION I : High-Throughput Strategies to Understand Non-coding Allelic Functions

9:00-9:45
Peter Sorger  | KEYNOTE SPEAKER
Harvard Medical School
Talk title available soon

9:45-9:50  Questions and Discussion

9:50-10:15
Kevin White
University of Chicago
Widespread Genetic Epistasis Among Cancer Genes

10:15-10:20  Questions and Discussion

10:20-10:30
Abstract Winner Platform Talk
Amnon Koren
Harvard Medical School
Genetic variation in human DNA replication timing

10:30-10:35  Questions and Discussion

10:35-11:00  BREAK

11:00-11:25
William Fairbrother
Brown University
Screening Variants for Defects in Splicing

11:25-11:30  Questions and Discussion

11:30-11:55
Tuuli Lappalainen
Columbia University
Interpreting Functional Variation in Human Genomes by Transcriptome Sequencing

11:55-12:00  Questions and Discussion

12:00-1:15  LUNCH


SESSION II : Integrative Approaches to Interpret the Function of Non-coding Alleles

1:15-2:00
George Church | KEYNOTE SPEAKER
Harvard Medical School
Talk title available soon

2:00-2:05  Questions and Discussion

2:05-2:30
Karen Mohlke
University of North Carolina at Chapel Hill
Regulatory variants at GWAS loci for complex metabolic traits

2:30-2:35  Questions and Discussion

2:35-3:00
Alkes Price
Harvard School of Public Health
Partitioning Heritability Across Functional Categories

3:00-3:05  Questions and Discussion

3:05-3:30  BREAK

3:30-3:40
Abstract Winner Platform Talk
Hilary Finucane
Massachusetts Institute of Technology
Partitioning heritability by functional category using summary statistics

3:40-3:45  Questions and Discussion

3:45-4:45
PANEL DISCUSSION
Interpreting the Function of Disease Alleles

Panelists:
Daniel MacArthur, Harvard Medical School
Soumya Raychaudhuri, Harvard Medical School
Barbara Stranger, University of Chicago
Shamil Sunyaev, Harvard Medical School

4:45-6:30  Poster Session and Reception | 2nd floor lounge

FRIDAY, NOVEMBER 21, 2014

8:30-9:00am  Breakfast | Joseph B. Martin Conference Center, 3rd Floor Rotunda


SESSION III : Interpreting the function of coding alleles

9:00-9:45
Nazneen Rahman  | KEYNOTE SPEAKER
The Institute of Cancer Research
Insights into the complexity of allelic function from clinical sequencing

9:45-9:50  Questions and Discussion

9:50-10:15
Mark Daly
Massachusetts General Hospital
Prioritizing and Interpreting Rare Variation & Exome Sequencing

10:15-10:20  Questions and Discussion

10:20-10:45
Jay Shendure
University of Washington
New Computational and Experimental Approaches to Variant Interpretation

10:45-10:50  Questions and Discussion

10:50-11:00
Abstract Winner Platform Talk
Luis Barrera
Harvard Medical School
Disease-associated mutations and coding variants in human transcription factors

11:00-11:05  Questions and Discussion

11:05-11:30
Nicholas Katsanis
Duke University
Modeling the Morbid Human Genome