In modern society important changes in lifestyle, nutritional behavior and overall environment have been reflected by a dramatic increase in metabolic disorders-associated diseases. Energy-sensing pathways have not adapted to the increased load of nutrients, and cause the whole organism to face an important challenge.
Endoplasmic reticulum stress (ER stress) can be considered a hallmark of different metabolic disorders and largely contributes to the development of diabetes, atherosclerosis and obesity. Nonetheless, more work is needed to fully elucidate the mechanisms of the stress response and how they link to the energy-sensing pathways.
My research in Dr. Hotamisligil’s lab focuses on the understanding of physiological responses to such metabolic abnormalities using physiological, genetic, biochemical, and molecular approaches.
2000. Bachelor degree in Exercise Physiology. University of Milan, Italy
2008. Ph.D in Physiology, Faculty of Medicine, University of Valencia, Spain
2005. Research fellow. Department of Medical and Occupational Sciences, University of Foggia, Italy
2008. Research fellow. Department of Physiology and Biophysics, University of Illinois at Chicago, IL, USA
2008-2011. Postdoctoral research fellow. Faculty of Pharmacy, University of Valencia, Spain
2011 to present. Postdoctoral research fellow. Harvard School of Public Health, Boston, MA, USA
Arduini A, Serviddio G, Tormos AM, Monsalve M, Sastre J. Mitochondrial dysfunction in cholestatic liver diseases. Front Biosci. (In publication)
Arduini A, Serviddio G, Escobar J, Tormos AM, Bellanti F, Viña J, Monsalve M, Sastre J. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G119-27.
Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Viña J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008 Jan;87(1):142-9.