In modern society important changes in lifestyle, nutritional behavior and overall environment have been reflected by a dramatic increase in metabolic disorders-associated diseases. Energy-sensing pathways have not adapted to the increased load of nutrients, and cause the whole organism to face an important challenge.
Endoplasmic reticulum stress (ER stress) can be considered a hallmark of different metabolic disorders and largely contributes to the development of diabetes, atherosclerosis and obesity. Nonetheless, more work is needed to fully elucidate the mechanisms of the stress response and how they link to the energy-sensing pathways.
My research in Dr. Hotamisligil’s lab focuses on the understanding of physiological responses to such metabolic abnormalities using physiological, genetic, biochemical, and molecular approaches.