Alex Carll - 5

Alex Carll

Research Fellow

Department of Environmental Health

655 Huntington Avenue
Building II, Room 217
Boston, MA 02115

Dr. Carll researches the cardiovascular and neural mechanisms of air pollution toxicity and seeks to identify the specific pollutant components responsible. Using laboratory rodents, he measures cardiac pressure, echocardiography, arterial pressure, and electrocardiography to determine if air pollutants alter cardiac pump function and geometry, impair vascular function, disturb cardiac conduction, and alter autonomic regulation of the cardiovascular system. Additionally, Dr. Carll incorporates stress tests and autonomic inhibition to determine if air pollutants impair innate abilities to respond to physiological stress. His recent studies have tested whether air pollutant-induced hypertension results from an imbalance in the autonomic nervous system and altered cardiac reflexes to blood pressure fluctuations.

From his prior research conducted at the United States Environmental Protection Agency, Dr. Carll has recently published results that suggest the autonomic nervous system mediates the adverse cardiac effects of inhaled air pollution in heart failure-prone rats. Accordingly, Dr. Carll has researched several models of heart failure in the rat. Among his earlier research accomplishments, he developed a novel model of drug-induced cardiomyopathy in rats and used it to demonstrate that preexisting cardiac disease confers susceptibility to air pollutant inhalation.

Education
Ph.D. 2012, University of North Carolina (UNC)-Chapel Hill, Gillings School of Global Public Health, Environmental Health Sciences.

M.S.P.H. 2008, UNC-Chapel Hill, School of Public Health, Environmental Sciences & Engineering.

A.B. 2004, Duke University, Environmental Science & Policy

Prior Training
Pre-doctoral Fellow, 2006-2012, U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Cardiopulmonary and Immunotoxicology Branch.

Publications:
Carll AP, Lust RM, Hazari MS, Perez CM, Krantz QT, King C, Winsett DW, Cascio WE, Costa DL, Farraj AK (2013). An Autonomic Link between Inhaled Diesel Exhaust and Impaired Cardiac Performance: Insight from Treadmill and Dobutamine Challenges in Heart Failure-Prone Rats. Toxicological Sciences. In press. http://www.ncbi.nlm.nih.gov/pubmed/23872579

Carll AP, Lust RM, Hazari MS, Perez CM, Krantz QT, King C, Winsett DW, Cascio WE, Costa DL, Farraj AK (2013). Diesel Exhaust Inhalation Increases Cardiac Output, Bradyarrhythmias, and Parasympathetic Tone in Aged Heart Failure-Prone Rats. Toxicological Sciences. 31(2):583-95. http://www.ncbi.nlm.nih.gov/pubmed/23047911

Carll AP, Hazari MS, Perez CM, Krantz QT, King C, Winsett DW, Costa DL, Farraj AK (2012). Whole and Particle-Free Diesel Exhausts Differentially Affect Cardiac Electrophysiology, Blood pressure, and Autonomic Balance in Heart Failure-Prone Rats. Toxicological Sciences. 128(2):490-9. http://www.ncbi.nlm.nih.gov/pubmed/22543275

Carll AP, Haykal-Coates N, Winsett DW, Hazari MS, Nyska A, Richards JH, Willis MS, Costa DL, Farraj AK (2011). Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. Toxicologic Pathology. 39(6):925-37. http://www.ncbi.nlm.nih.gov/pubmed/21878552

Carll AP (review), Willis MS, Lust RM, Costa DL, Farraj AK (2011). Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure. Cardiovascular Toxicology. 11(2):91-112. http://www.ncbi.nlm.nih.gov/pubmed/21279739

Carll AP, Haykal-Coates N, Winsett DW, Rowan WH 3rd, Hazari MS, Ledbetter AD, Nyska A, Cascio WE, Watkinson WP, Costa DL, Farraj AK (2010). Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhalation Toxicology. 22(5):355-68. http://www.ncbi.nlm.nih.gov/pubmed/20121584

Additional Publications:
Perez CM, Ledbetter AD, Hazari MS, Haykal-Coates N, Carll AP, Winsett DW, Costa DL, Farraj AK. Hypoxia Stress Test Reveals Exaggerated Cardiovascular Effects in Hypertensive Rats after Exposure to the Air Pollutant Acrolein (2013). Toxicological Sciences. 132(2):467-77.

Farraj AK, Hazari MS, Winsett DW, Kulukulualani A, Carll AP, Haykal-Coates N, Lamb CM, Lappi E, Terrell D, Cascio WE, Costa DL (2012). Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability. Environmental Health Perspectives. 120(3):348-54.

Lamb CM, Hazari MS, Haykal-Coates N, Carll AP, Krantz QT, King C, Winsett DW, Cascio WE, Costa DL, Farraj AK (2012). Divergent Electrocardiographic Responses to Whole and Particle-Free Diesel Exhaust Inhalation in Spontaneously Hypertensive Rats. Toxicological Sciences. 125(2):558-68.

Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, Ledbetter AD, Carll AP, Bruno M, Ghio A, Costa DL (2011). ST Depression, Arrhythmia, Vagal Dominance, and Reduced Cardiac MicroRNA in Particulate-exposed Rats. American Journal of Respiratory Cell and Molecular Biology 44(2):185-96.

Farraj AK, Haykal-Coates N, Winsett DW, Hazari MS, Carll AP, Rowan WH, Ledbetter AD, Cascio WE, Costa DL (2009). Increased non-conducted P-wave arrhythmias after a single oil fly ash inhalation exposure in hypertensive rats. Environmental Health Perspectives. 117(5):709–715.

LaGier AJ, Manzo ND, Carll AP, Jaskot RH, Slade R, Richards JH, Winsett DW, Farraj AK, Dye JA (2008). A hyperlipidemic rabbit model provides new insights into pulmonary zinc exposure effects on cardiovascular health. Cardiovascular Toxicology. 8(4):195-206.