An Pan

An Pan

Research Associate

Department of Nutrition

655 Huntington Avenue
Building 2, Room 351
Boston, Massachusetts 02115
apan@hsph.harvard.edu

Publications

First or Co-First Authors:

  • Pan A, Sun Q, Okereke O, Manson JE, Rexrode KM, Hu FB. Depression and the risk of stroke morbidity and mortality: a systematic review and meta-analysis. JAMA. 2011; 306(11):1241-1249. http://www.ncbi.nlm.nih.gov/pubmed/21934057
  • Pan A, Schernhammer ES, Sun Q, Hu FB. Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Medicine. 2011; 8(12):e1001141. http://www.ncbi.nlm.nih.gov/pubmed/22162955
  • Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ, Willett WC, Hu FB. Red meat consumption and mortality: results from two cohort studies. Archives of Internal Medicine. Published online March 12, 2012; doi:10.1001/archinternmed.2011.2287.
  • Pan A, Keum N, Sun Q, Okereke O, Manson JE, Hu FB. Depression and metabolic syndrome: A systematic review and meta-analysis. Diabetes Care. 2012; Accepted for publication.
  • Wedick NM,* Pan A,* Cassidy A, Rimm EB, Sampson L, Rosner B, Willett WC, Hu FB, Sun Q, van Dam RM. Dietary flavonoid intake and risk of type 2 diabetes. American Journal of Clinical Nutrition. 2012; Accepted for publication. (* co-first author)
  • Pan A, Sun Q, Okereke O, Rexrode KM, Rubin RR, Lucas M, Willett WC, Manson JE, Hu FB. Antidepressant Medication Use and Risk of Type 2 Diabetes: Results from Three Cohorts of American Adults. Diabetologia. 2012;55(1):63-72. http://www.ncbi.nlm.nih.gov/pubmed/21811871
  • Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Willett WC, Hu FB. Red Meat Consumption and Risk of Type 2 Diabetes: Three Cohorts of U.S. Adults and an Updated Meta-analysis. American Journal of Clinical Nutrition. 2011;94(4):1088-96. http://www.ncbi.nlm.nih.gov/pubmed/21831992
  • Pan A, Okereke O, Sun Q, Logroscino G, Manson JE, Willett WC, Ascherio A, Hu FB, Rexrode KM. Depression and Incident Stroke in Women. Stroke. 2011; 42(10):2770-5. http://www.ncbi.nlm.nih.gov/pubmed/21836097
  • Pan A, Sun Q, Czernichow S, Kivimaki M, Okereke O, Lucas M, Manson JE, Ascherio A, Hu FB. Bidirectional Association between Depression and Obesity in Middle-aged and Older Women. International Journal of Obesity. 2011; epub 7 June 2011; doi:10.1038/ijo.2011.111. http://www.ncbi.nlm.nih.gov/pubmed/21654630
  • Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Willett WC, Manson JE, Rexrode KM, Ascherio A, Hu FB. Increased mortality risk in women with depression and diabetes mellitus. Archives of General Psychiatry. 2011 Jan;68(1):42-50. http://www.ncbi.nlm.nih.gov/pubmed/21199964
  • Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Manson JE, Willett WC, Ascherio A, Hu FB. Bidirectional Association between Depression and Type 2 Diabetes in Women. Archives of Internal Medicine. 2010 Nov 22;170(21):1884-91. http://www.ncbi.nlm.nih.gov/pubmed/21098346
  • Pan A, Hu FB. Effects of carbohydrate on satiety: difference between liquid and solid food. Current Opinion in Clinical Nutrition and Metabolic Care. 2011;14(4):385-90.  http://www.ncbi.nlm.nih.gov/pubmed/21519237
  • Pan A, Hu FB. Do individuals with both diabetes and depression have an increased mortality risk? Diabetes Management. 2011;1(3):251-254. dio:10.2217/DMT.11.25. http://www.futuremedicine.com/toc/dmt/1/3
  • Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on the blood lipids. American Journal of Clinical Nutrition. 2009, 90(2):288-97. Pubmed Link
  • Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X. Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese. Journal of Affective Disorders. 2009 Feb 25. [Epub ahead of print], doi:10.1016/j.jad.2009.02.002.  Pubmed Link
  • Pan A, Demark-Wahnefried W, Ye X, Yu Z, Li H, Qi Q, Sun J, Chen Y, Chen X, Liu Y, Lin X. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. British Journal of Nutrition. 2009; 101:1145-1149. Pubmed Link
  • Pan A, Franco OH, Ye J,Demark-Wahnefried W,Ye W,Yu Z,Li H,Lin X. Soy protein intake has sex-specific effects on the risk of metabolic syndrome in middle-aged and elderly Chinese. The Journal of Nutrition. 2008 Dec;138(12):2413-21.  Pubmed Link
  • Pan A, Ye X, Franco OH, Li H, Yu Z, Zou S, Zhang Z, Jiao S, Lin X. Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study. Journal of Affective Disorders. 2008 Jul; 109(1-2):75-82.  Pubmed Link
  • Pan A, Franco OH, Wang YF, Yu ZJ, Ye XW, Lin X. Prevalence and geographic disparity of depressive symptoms among middle-aged and elderly in China. Journal of Affective Disorders. 2008 Jan; 105 (1-3):167-75.  Pubmed Link
  • Pan A, Ye X, Franco OH, Li H, Yu Z, Wang J, Qi Q, Gu W, Pang X, Liu H, Lin X. The association of depressive symptoms with inflammatory factors and adipokines in middle-aged and older chinese. PLoS ONE. 2008 Jan; 3(1):e1392.  Pubmed Link
  • Pan A, Sun J, Chen Y, Ye X, Li H, Yu Z, Wang Y, Gu W, Zhang X, Chen X, Demark-Wahnefried W, Liu Y, Lin X. Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS ONE. 2007 Nov; 2(11):e1148.  Pubmed Link

Coauthors:

  • Bernstein AM, Pan A, Rexrode KM, Stampfer M, Hu FB, Mozaffarian D,Willett WC. Major dietary protein sources and the risk of stroke in men and women. Stroke. 2011 Dec 29. [Epub ahead of print]; DOI: 10.1161/STROKEAHA.111.633404. http://www.ncbi.nlm.nih.gov.ezp-prod1.hul.harvard.edu/pubmed/22207512
  • Hu E, Pan A, Malik V, Sun Q. White rice consumption and risk of type 2 diabetes: a meta-analysis and systematic review. BMJ (British Medical Journal). 2012; Accepted for publication.
  • Wu JHY, Micha R, Imamura F, Pan A, Biggs LM, Ajaz O, Djousse L, Hu FB, Mozaffarian D. Omega-3 Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis. British Journal of Nutrition. 2012; Accepted for publication.
  • Zhang G, Pan A, Zong G, Yu Z, Wu H, Chen X, Tang L, Feng Y, Zhou H, Chen X, Li H, Hong B, Malik VS, Willett WC, Spiegelman D, Hu FB, Lin X. Substituting White Rice with Brown Rice for 16 Wk did not Substantially Affect Metabolic Risk Factors in Middle-aged Chinese. The Journal of Nutrition. 2011;141(9):1685-90. http://www.ncbi.nlm.nih.gov/pubmed/21795429
  • Sun L, Pan A, Yu Z, Li H, Shi A, Yu D, Zhang G, Zong G, Liu Y, Lin X. Snoring, cardio-metabolic biomarkers and metabolic syndrome in apparently healthy Chinese. PLoS ONE. 2011; 6(11): e27515. http://www.ncbi.nlm.nih.gov/pubmed/22110665
  • Lucas M, Mekary R, Pan A, Mirzaei F, O’Reilly EJ, Willett WC, Koenen K, Okereke O, Ascherio A. Relation Between Clinical Depression Risk and Physical Activity and Time Spent Watching Television in Older Women: A 10-Year Prospective Follow-up Study. American Journal of Epidemiology. 2011; 174(9):1017-27. http://www.ncbi.nlm.nih.gov/pubmed/21984659
  • Lucas M, Mirzaei F, Pan A, Okereke O, Willett WC, O’Reilly EJ, Koenen K, Ascherio A. Coffee, caffeine, and risk of depression among women. Archives of Internal Medicine. 2011;171(17):1571-8. http://www.ncbi.nlm.nih.gov/pubmed/21949167
  • Lucas M, Mirzaei F, O’Reilly EJ, Pan A, Willett WC, Kawachi I, Koenen K, Ascherio A. Omega-3 and omega-6 fatty acid intake and the risk of clinical depression in women: a 10-year prospective follow-up study. American Journal of Clinical Nutrition. 2011; 93:1337-1343. http://www.ncbi.nlm.nih.gov/pubmed/21471279
  • Wu H, Pan A, Yu Z, Qi Q, Lu L, Zhang G, Yu D, Zong G, Zhou Y, Chen X, Tang L, Feng Y, Zhou H, Chen X, Li H, Demark-Wahnefried W, Hu FB, and Lin X. Lifestyle Counseling and Supplementation with Flaxseed or Walnuts Influence the Management of the Metabolic Syndrome. The Journal of Nutrition. 2010 Nov;140(11):1937-42. http://www.ncbi.nlm.nih.gov/pubmed/20826632
  • Zhang G, Malik VS, Pan A, Kumar S, Holmes M, Spiegelman D, Lin X, Hu FB. Substituting Brown Rice for White Rice for Diabetes Prevention: A Focus Group Study in Chinese Adults. Journal of the American Dietetic Association. 2010 Aug;110(8):1216-21. http://www.ncbi.nlm.nih.gov/pubmed/20656097Opens in New Window
  • Haseli-Mashhadi N, Pan A, Ye X, Wang J, Qi Q, Liu Y, Li H, Yu Z, Lin X, Franco OH. Self-Rated Health in Middle-aged and Elderly Chinese: distribution, factors and associations with cardio-metabolic risk factors. BMC Public Health. 2009 Sep 29;9:368.  Pubmed LinkOpens in New Window
  • Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, Li X, Yang X, Chen Y, Lin X. Plasma 25-hydroxyvitamin D Concentration and Metabolic Syndrome among Middle-aged and Elderly Chinese. Diabetes Care. 2009, 32(7):1278-83.  Pubmed Link
  • Haseli-Mashhadi N, Dadd T, Pan A, Yu Z, Lin X, Franco OH. Sleep Quality in Middle-aged and Elderly Chinese: distribution, associated factors and associations with cardio-metabolic risk factors. BMC Public Health. 2009 May 9, 9:130.  Pubmed Link
  • Yu Z, Ye X, Wang J, Qi Q, Franco OH, Rennie KL, Pan A, Li H, Liu Y, Hu FB, Lin X. Associations of Physical Activity With Inflammatory Factors, Adipocytokines, and Metabolic Syndrome in Middle-Aged and Older Chinese People. Circulation. 2009, 119(23):2969-77  Pubmed Link
  • Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB, Lin X. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8 and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008; 57(10):2834-2842.  Pubmed Link
  • Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, Liu Y, Lin X. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese. The Journal of Clinical Endocrinology & Metabolism. 2008; 93(12):4690-4696.  Pubmed Link
  • Qi Q, Wang J, Li H, Yu Z, Ye X, Hu FB, Franco OH, Pan A, Liu Y, Lin X. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese. European Journal of Endocrinology. 2008; 159(5):585-93.  Pubmed Link
  • Qi Q, Wu Y, Li H, Loos RJ, Hu FB, Sun L, Lu L, Pan A, Liu C, Wu H, Chen L, Yu Z, Lin X. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia. 2009; 52(5):834-843.  Pubmed Link

Education

B.S.  in Biochemistry, 2000-2004,   Nanjing University, Nanjing, China   Link

Ph.D. in Biochemistry and Molecular Biology, 2004-2009,  Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China  Link

Research Interests

  • Epidemiology study to investigate the effects of environmental (diet/lifestyle) on the development of obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease.
  • Nutrition intervention studies on individuals with type 2 diabetes and metabolic diseases.
  • Mental health (especially depression), and its relation to metabolic diseases and mortality.
  • Specific interest in phytoestrogens (lignan, isoflavone), flavonoids, n-3 fatty acids, carbohydrate quality, flaxseed, soy, walnuts, brown rice, red meat, coffee, sugar-sweetened beverage, water.