The laboratory conducts large scale environmental and epidemiology studies to investigate environmental programming and mechanisms of human disease. We use state-of-art technologies in epigenetics to identify novel disease mechanisms or molecular records of past environmental exposures and life experiences. We have recently initiated a new area of research of environmental mitochondriomics dedicated to discovering in mitochondria novel sensors and mediators of environmental effects. The highly dimensional data generated in the lab are handled through advanced approaches in computational epigenomics to analyze the complex relationships between genes and their environment, as well as basic biological and quantitative science.