Botswana Harvard AIDS Institute

RESEARCH: Acute Infection

Tshedimoso
BHP012, BHP009

Principal Investigator: Vladimir Novitsky
Funding: NIH

Objectives:

To identify virologic and immunologic markers in primary HIV-1C infection that are associated with viral set point (VSP).
To identify individuals as early as possible in HIV-1C infection and characterize viral and immune parameters in primary HIV-1C infection in Botswana.

Enrollment: March 2004– April 2008

Follow Up: Complete April 2010

Publications:
Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection. Virology. 2011 Oct 17. [Epub ahead of print]

Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS, Jul 31;25(12):1515-22 (2011)

Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection. PLoS One. 6:e16714 (2011)

Dynamics and Timing of in Vivo Mutations at Gag Residue 242 during Primary HIV-1 Subtype C Infection. Virology. 403:37-46 (2010).

Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47-59 (2009)

Timing Constraints of in Vivo Gag Mutations during Primary HIV-1 Subtype C Infection. PLoS One. 4:e7727 (2009)

Better Control of Early Viral Replication Is Associated with Slower Rate of Elicited Antiviral Antibodies in the Detuned EIA during Primary HIV-1C Infection. J. Acquir. Immune Defic. Syndr. 52:265-272 (2009)

Viral Load and CD4+ T Cell Dynamics in Primary HIV-1 Subtype C Infection. J. Acquir. Immune Defic. Syndr. 50:65–76 (2009)

Identification of primary HIV-1C infection in Botswana. AIDS Care. Aug;20 (7):806-11 (2008)

A Seronegative Case of HIV-1 Subtype C Infection in Botswana. Clin. Infect. Dis. 45:e68-71 (2007)

© Copyright 2011 Botswana Harvard AIDS Institute