Botswana Harvard AIDS Institute

RESEARCH: HIV Adult Treatment

Mashi Plus: Virologic Response after NVP-containing HAART
BHP019

Principal Investigator: Shahin Lockman
Funding: NIH

Objectives:
To determine the response to nevirapine containing HAART among women who have previously taken single-dose nevirapine (NVP) for the prevention of MTCT.

Enrollment: March 2001–October 2003

Follow Up: Complete March 2008

Publications:
Ultrasensitive Detection of Minor Drug-Resistant Variants for HIV after Nevirapine Exposure Using Allele-Specific PCR: Clinical Significance. AIDS Res. Hum. Retroviruses. 26:293-300 (2010)

Improvement in Allele-Specific PCR Assay with the Use of Polymorphism-Specific Primers for the Analysis of Minor Variant Drug Resistance in HIV-1 subtype C. J. Virol. Methods. 149:69-75 (2008)

Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine. N. Engl. J. Med. 356:135-147 (2007)

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