RESEARCH: HIV Prevention
Netefatso: Phase III Randomized Placebo-Controlled Trial of
HSV-2 Suppression to Prevent HIV Transmission among HIV
Sero-Discordant Couples
BHP015
Principal Investigator: Max Essex
Funding: Bill & Melinda Gates Foundation
Objectives:
To determine if giving the medication acyclovir to HIV infected individuals also infected with the virus that causes genital herpes (HSV-2) reduces the risk of these individuals transmitting HIV to their uninfected sexual partner.
Enrollment:
March 2005–October 2008
Follow Up: Complete February 2008
Publications: Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. N Engl J Med. 362:427 (2010) Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomized placebo-controlled trial. The Lancet. 375: 824-833. (2010) Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk. PLoS One.5:e12598. (2010) Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE. 4:e5272 (2009) |