RESEARCH

HIV Prevention

• Mochudi Prevention Project
  
  
• HPTN052: A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Sero-discordant Couples
  
  
• Netefatso: Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission among HIV Sero-discordant Couples
  
  
• Infant Male Circumcision in Gaborone, Botswana, and Surrounding Areas: Feasibility, Safety and Acceptability
  
  
• Acceptability of Adolescent Male Circumcision among Adolescent Boys and Their Parents/Legal Guardians in Mochudi and Molepolole, Botswana

Prevention of Mother-to-Child Transmission (PMTCT)

• Mashi: Prevention of Milk-Borne Transmission of HIV-1C in Botswana
  
  
• Mma Bana: A Randomized Trial of Lopinavir/Ritonavir/Combivir vs. Abacavir/Zidovudine/Lamivudine for Virologic Efficacy and the Prevention of Mother-to-Child HIV Transmission among Breastfeeding Women with CD4 Counts > 200 cells/mm3 in Botswana

Maternal Health during and after PMTCT

• Thari: A5208 Optimal Combination Therapy After Nevirapine Exposure (OCTANE)
  
  
• 1077HS: HAART Standard version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere) (An IMPAACT Study)

HIV and Child Health

• Tshipidi: Effects of HIV and ARV Exposure on Child Health and Neurodevelopment, Botswana
  
  
• Mpepu: A Randomized Study of Cotrimoxazole (CTX) Prophylaxis and Longer Breastfeeding Duration to Improve Survival among HIV-Exposed Infants in Botswana
  
  
• Safety of Cotrimoxazole Prophylaxis in HIV- and HAART-Exposed Infants in Botswana
  
  
• Birth Outcomes

HIV Adult Treatment

• Mashi Plus: Virologic Response after NVP-containing HAART
  
  
• Tshepo: Adult Anti-retroviral Treatment and Resistance Study
  
  
• Bomolemo: The Botswana National Evaluation Models of HIV Care: A Study Evaluating the Efficacy and Tolerability of Tenofovir and Emtricitabine(Truvada™) as the Nucleoside Reverse Transcriptase Inhibitor (NRTI) Backbone As First-Line HAART for Adults In Botswana
  
  
• STRIDE: A5221 A Strategy Study of Immediate vs.Deferred Initiation of Antiretroviral Therapy for AIDS Disease-Free Survival in HIV-Infected Persons Treated for Tuberculosis with CD4 <250 Cells/mm3

Acute Infection

• Tshedimoso

  Photo by Flavio Takemoto

Host Genetics

• Host Genetics/GWAS of HIV-1 Subtype C Infection, Progression, and Treatment in Africa

Progression

• Botsogo: The Natural History of HIV-1 Sybtype C Disease Progression
  
  
• Dikotlana: Micronutrient Therapy and HIV in Botswana

Co-Morbidity & Opportunistic Infections

• HIV and Malignancy in Botswana
  
  
• A5265: A Phase III, Open-Label, Randomized, Assessment-Blinded Clincal Trial to Compare the Safety and Efficacy of Topical Gentian Violet to that of Nystatin Oral Suspension for the Treatment of Oropharyngeal Candidiasis in HIV-1 Infected Participants in Non-US Settings (An ACTG Study)

Vaccines

Photo by Brian Hoskins

• Lerothodi: P1072 Safety and Immunogenicity of a Live, Attenuated Rotavirus Vaccine (RotaTeq™) in HIV-Infected and Uninfected Children Born to HIV-Infected Mothers
  
  
• HVTN 048: A Phase I Dose-Escalation Clinical Trial to Evaluate the Safety and Immunogenicty of the EP HIV-1090 DNA Vaccine
  
  
• HVTN 059: A Phase I Dose-Escalation Safety and Immunogenicity Trial of an Alphavirus Replicon HIV-1 Subtype C gag Vaccine (AVX101)
  
  
• HVTN 903: An HIV Vaccine Preparedness Study

Drug Resistance

• Nevirapine Resistance of Women who Received Nevirapine for PMTCT of HIV
  
  
• Tshepo: Adult Anti-retroviral Treatment and Resistance Study

Virology

• HIV-1 Viral Tropism among Subtype C Viruses: Prevalence, Shifts with Antiretroviral Therapy and Breast Milk Compartmentalization
  
  
• Maternal Cofactors in HIV-1C Perinatal Transmission
  
  
• CTL Study: Identification of HLA Restricting CTL epitopes of HIV 1-C

Healthcare Delivery

• Models of Care
  
  
• Tokafatso