HIV Prevention

	Mashi Study: Prevention of Mother to Infant Transmission Study The Mashi study is a clinical trial investigating novel approaches in the prevention of mother-to-child-transmission of HIV (PMTCT).
	Mma Bana Study The Mma Bana Study is a treatment trial to determine the optimal HAART regimen to prevent mother-to-child HIV transmission (MTCT).
	Netefatso Study: HSV-2/HIV Transmission The Netefatso Study is the first study to evaluate whether it is possible to reduce transmission of HIV-1C by treating genital herpes with acyclovir.
	Vaccine Development/Maiteko a Tshireletso Vaccine Initiative Along with the laboratory investigations dedicated to developing a safe and effective HIV vaccine for southern Africa, the Botswana–Harvard AIDS Institute Partnership is currently collaborating with local, regional and international institutions and organizations to develop the necessary infrastructure and community awareness to conduct vaccine trials in Botswana.

HIV Care and Treatment

	Basadi Treatment Study The Basadi Treatment study is investigating how HSV-2 co-infection influences genital tract shedding of HIV-1C among women taking anti-retroviral therapy.
	Cost-Effectiveness Study The Cost Effectiveness Study will address key questions related to the costs and cost-effectiveness of implementing HAART at a national level in Botswana.
	Micronutrient Study The Micronutrient Therapy Study will investigate the importance of micronutrients in relation to HIV disease progression.
	OCTANE Study The OCTANE Study is investigating whether women starting anti-retroviral treatment will have a better response to a regimen containing nevirapine versus a regimen containing a protease inhibitor.
	Tshepo Study: Adult Antiretroviral Treatment and Resistance The Tshepo Study examines the use of antiretroviral therapy for the treatment of HIV-1C infection in Botswana.

Social and Behavioral Studies

Behavioral Studies Researchers working with the Botswana-Harvard Partnership are investigating behavioral and social components associated with HIV infection and AIDS.

HIV Molecular Research

	Cytotoxic T Lymphocytes (CTL) and Human Leukocyte Antigens (HLA) Two studies investigating cytotoxic T lymphocytes (CTL) and human leukocyte antigens (HLA) suggest that the mapping of CTL epitopes, on the basis of common HLA specificities among the target population, will contribute to the design of a more efficient HLA-based AIDS vaccine.
	Genomic Analysis of Genetic Characteristics of HIV-1C In order to better understand how HIV is passed from mother- to-infant, virus isolated from HIV-infected infants is being compared to virus isolated from samples of blood, breast milk, and cervicovaginal fluid from their mothers.
	Molecular Characterization of HIV-1C More than 50 different isolates of the HIV-1C virus have been isolated from different regions in Botswana and researchers have characterized their molecular and biologic traits.
	Tshedimoso Study The Tshedimoso Study is investigating the immune characteristics of individuals who are newly infected with HIV-1C.