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In addition to the aims outlined in the Mashi Study, the study also seeks to compare the infant health outcomes of breast-fed infants vs. formula-fed infants. Two infant health outcomes adjunct studies will quantify health outcomes among three groups of infants: 1) infants born to HIV-infected women randomized to breast-feed, 2) infants born to HIV-infected women randomized to formula feed, and 3) infants born to HIV-uninfected mothers and who are encouraged to breast feed. The primary objectives of the Mashi adjunct studies are to determine the rates of diarrheal and respiratory illnesses and bloodstream infections, and the range of pathogens present among each of these groups, and the rate of infant mortality. These data will help determine the overall morbidity and mortality among infants randomized to formula feed vs. those randomized to breast-feed. Secondary objectives include the correlation between breast milk immunoglobulins and infant health outcomes, and the association between oropharyngeal colonization with bacterial pathogens and infant feeding strategy. |
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