RESEARCH: Prevention of Mother-to-Child Transmission (PMTCT)
Mma Bana: A Randomized Trial of Lopinavir/Ritonavir/Combivir vs. Abacavir/Zidovudine/Lamivudine for Virologic Efficacy and the Prevention of Mother-to-Child HIV Transmission among Breastfeeding Women with CD4 Counts > 200 cells/mm3 in Botswana
BHP016
Principal Investigator: Roger Shapiro
Funding: NIH
Objectives:
To determine the optimal HAART regimen to prevent mother-to-child HIV transmission among 700 HIV-infected breastfeeding women in Botswana.
Enrollment: July 2006–May 201
Follow Up: Complete September 2010
Publications: Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk, in the Mma Bana Study, Botswana. Antivir Ther. 2012 Nov 26.
Increased Risk of Severe Infant Anemia Following Exposure to Maternal HAART, Botswana. JAIDS. Apr;56(5):428-36. (2011) Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. JAIDS. 1:56(2):131-8. (2011) Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010) Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana. J. Infect. Dis. 199:414-418 (2009) |