CTL Study: Identification of HLA Restricting CTL epitopes of HIV 1-C
Principal Investigator: Max Essex
To determine how different genetic backgrounds of people and different subtypes of HIV in southern Africa influence cell mediated immune response in HIV 1-C infection.
Enrollment: February 2000–?
Reduced Viral Replication Capacity of HIV-1 Subtype C Caused by CTL Escape Mutations in HLA-B57 Epitopes of Capsid Protein. J. Virol. 83:2460-2468 (2009).
Identification of Class I HLA-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses. 23:165-174 (2007).
Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection. Virology. 349:142-155 (2006)
Covariability of Selected Amino Acid Positions for HIV Type 1 Subtypes C and B. AIDS Res. Hum. Retroviruses. 21:1016-1030 (2005)
Major Histocompatibility Complex Class II (HLA-DRB and -DQB) Allele Frequencies in Botswana: Association with Human Immunodeficiency Virus Type 1 Infection. Clin. Diagn. Lab. Immunol. 12:1020-8 (2005).
Association between Virus-Specific CTL Responses and Plasma Viral Load in Human Immunodeficiency Virus Type 1 Subtype C Infection. J. Virol. 77:882-890 (2003)
Magnitude and Frequency of CTL Responses: Identification of Immunodominant Regions in HIV-1 Subtype C. J. Virol. 76:10155-10168 (2002)
Human Immunodeficiency Virus Type 1 Subtype C Molecular Phylogeny: Consensus Sequence for an AIDS Vaccine Design? J. Virol. 76:5435-5451 (2002)
Identification of most frequent HLA class I antigen specificities in Botswana: relevance for HIV vaccine design. Hum Immunol. Feb;62(2):146-56 (2001)
Identification of HIV-1C Gag-, Tat-, Rev-, and Nef-specific Elispot-based CTL Responses for AIDS Vaccine Design. J. Virol. 75:9210-9228 (2001)
HIV-1 A/J Recombinant with a Pronounced pol Gene Mosaicism. AIDS Res. Hum. Retroviruses 16:1015-1020 (2000).