2006 Summer Program in Quantitative Sciences for Public Health Research

Group Projects and Mentors

Faculty Mentor: Dr. Sonia Hernandez Diaz
Graduate Student Mentor: Shakira Franco, PhD
Program Participants: Justine Frazier and Nicholas Wells

Project Title: Childhood Malnutrition and Postwar Reconstruction in Rural El Salvador

Project Description: In 1998, six years after the peace agreement that concluded the Civil War in El Salvador, a study attempted to describe the association between the reconstruction effort and child health in one rural area, using child nutrition as an indicator. The hypotheses were: (1) prevalence of childhood malnutrition, in the form of stunting, was still high even where large amounts of post-war reconstruction aid had been received, and (2) delays in both implementation of the post-war land transfer process and provision of basic services to the target population were associated with child malnutrition. In this project, students described associations between post-war social and economic assistance programs, and child health status as reflected by nutrition in a population of resettled rural refugees. Students used descriptive analysis and univariate tests to evaluate associations between socioeconomic factors and stunting, and multivariate logistic regression to estimate adjusted odds ratios and their 95% confidence intervals.



Dr. Hernandez Diaz, Nick, Justine, and Shakira

Faculty Mentor: Dr. Stuart Lipsitz
Graduate Student Mentor: Regginal Tucker-Seeley, PhD candidate
Program Participants: Jennifer Tillett, Shelah Roanhorse, and Quincy Greene

Project Title: Differences in Nutritional Intake Between Black and White Males Presenting for Prostate Cancer Screening

Project Description: Increasing evidence suggests that diet and nutrition modify the risk of each of certain cancers, and in particular, prostate cancer. In the U.S. during 1988-1992, the incidence rates of prostate, stomach, oral cancer, and lung cancer were 31%, 86%, 35%, and 48% higher in black males than white males. Although differences in other risk factors (including smoking) account for much of the racial diversity in incidence of these cancers, it is possible that some of the racial differences in cancer risk and mortality, particularly for prostate cancer, may be related to differences in nutrition. During the project, students tested for differences in reported dietary intake between black and white males who attended a prostate cancer screening using descriptive analyses including medians, non-parametric tests for differences between nutritional intake black and white males, age-adjusted medians for blacks and whites using median regression analyses.



Dr. Lipsitz, Jennifer, Quincy, Shelah, and Regginald

Faculty Mentor: Dr. Jonathan Levy
Graduate Mentor: Lisa Baxter, PhD candidate
Program Participants: Jennifer Lykken and Gabriel Murillo

Project Title: Indoor and Outdoor Polycyclic Aromatic Hydrocarbon Concentrations in Urban Neighborhoods

Project Description: Asthma risks are known to be elevated in low-income urban settings, but it is unclear what factors explain these disparities. One hypothesized contributor is diesel-related air pollution, of which polycyclic aromatic hydrocarbons (PAHs) are an important constituent. A complication is the fact that people spend much more time indoors than outdoors, and there are other sources of PAHs inside the home, such as cooking or grilling of meat. In order to understand which populations are highly exposed to PAHs, students evaluated the relationship between measured PAH levels and both traffic and indoor sources. They used descriptive statistics and univariate/multivariate regression modeling to determine whether PAH concentrations measured outside of the home are correlated with traffic counts, and specifically with diesel traffic, and to determine the strength of the indoor-outdoor PAH relationship and the potential contribution from indoor sources. Students presented their results at the Exposure Working Group at the Harvard School of Public Health.



Jennifer, Lisa, and Gabriel

Faculty Mentor: Dr. Christoph Lange
Graduate Student Mentor: David Fardo, PhD candidate
Program Participants: Rosa Maria Alvarez and Kody Kinsley

Project Title: Determining Genetic Determinants of Alcoholism using Family-Based Association Testing (FBAT)

Project Description: In this research project, students used Family-Based Association Testing (FBAT) to investigate genetic determinants of alcoholism. FBATs can generally be defined as a class of tests that use family data to examine whether genetic variation across individuals may be used to explain corresponding phenotypic (or disease) variation. Students applied these tests to the Collaborative Study on the Genetics of Alcholism (COGA), which contains genetic and phenotype information on approximately 1600 family members. The goal of the project was to identify any significant genetic markers of alcoholism (or surrogate phenotypic traits). For the analysis, students selected the appropriate tests in PBA and used the FBAT screening process to find the most promising SNPs for analysis.



Dr. Lange, Kody, Rosa, and David