Harvard School of Public Health
Department of Biostatistics

AIDS Research

Select Publications

Lagakos, S., Barraj, L., and De Gruttola, V. (1988), "Nonparametric Analysis of Truncated Survival Data, with Application to AIDS", Biometrika 75:515-523.

De Gruttola, V. and Lagakos, S. (1988), "Analysis of Doubly Censored Survival Data, with application to AIDS", Biometrics 45:1-12.

Volberding, P.A., Lagakos, S.W., Koch, M. et al (1990), "Safety and Efficacy of Zidovudine in Asymptomatic HIV Infected Individuals with Less Than 500 CD4+ Cells/mm", New England Journal of Medicine 322:941-949, April 5.

De Gruttola V, Lange N, and Dafni R. (1991). Modeling the progression of HIV infection. Journal of the American Statistical Association, 86:569-577.

De Gruttola, V., Tu, X.M. and Pagano, M. (1992). Pediatric AIDS in New York City: estimating the distributions of infection, latency and reporting delay and projecting future incidence. Journal of the American Statistical Association, 87:633-640.

Tu, X.M., Litvak, E. and Pagano, M. (1992). Issues in human immunodeficiency virus (HIV) screening programs. American Journal of Epidemiology, 136:244-255.

Bellocco, R., MaWhinney, S., Pagano, M. , Rezza, G., Zaccarelli, M. and Greco, D. (1993). La sorveglianza dell AIDS in Italia: stima del ritardo di notifica e interpretazione della curva epidemica. Giornale Italiano AIDS, 4:44-48.

MaWhinney, S., Pagano, M. and Thomas, P.A. (1993). Age at AIDS diagnosis for children with perinatally-acquired HIV. Journal of AIDS, 6:1139-1144.

Tu, X.M., Meng, X. and Pagano, M. (1993). Survival differences and trends in patients with the acquired immunodeficiency syndrome in the United States. Journal of AIDS, 6:1150-1156.

Tu, X.M., Meng, X. and Pagano, M. (1993). The AIDS epidemic: estimating survival after AIDS diagnosis from surveillance data. Journal of the American Statistical Association, 88:18-28.

Connor E, Sperling R, Gelber R, et al. and the Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. (1994). Reduction of maternal-infant transmission of human immunodeficiency virus 1 with zidovudine treatment: Results of AIDS Clinical Trials Group Protocol 076. N Engl J Med; 331:1173-1180.

Gauvreau, K., De Gruttola, V., Bellocco, R. and Pagano, M. (1994). The effect of covariates on the induction time of AIDS using improved imputation of exact seroconversion times. Statistics in Medicine, 13:2021-2030.

Litvak, E., Tu, X.M. and Pagano, M. (1994). Screening for the presence of a disease by pooling sera samples, Journal of the American Statistical Association, 89:424-434.

MaWhinney, S., and Pagano, M. (1994). Distribution of the latency period for perinatally acquired AIDS. Statistics in Medicine, 13:2031-2042.

Pagano, M. , Tu, X.M., De Gruttola, V., and MaWhinney, S. (1994). Regression analysis of censored and truncated data: Estimating reporting delay distributions and AIDS incidence from surveillance data. Biometrics, 50:1203-1214.

Tu, X.M., Litvak, E. and Pagano, M. (1994). Screening tests: can we get more by doing less? Statistics in Medicine, 13:1905-1919.

Khouri, Y.F., McIntosh, K., Cavacini, L., Posner M., Pagano, M., Tuomala, R. and Marasco, W.A. (1995). Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies. Journal of Clinical Investigation, 95(2):732-737.

Tu, X.M., Litvak, E. and Pagano, M. (1995). On the Informativeness and Accuracy of Pooled Testing when Estimating Prevalence of a Rare Disease: Application to HIV Screening, Biometrika, 82:287-298.

Volberding, P.A., Lagakos, S.W., Grimes, J.M. et al (1995). "A comparison of immediate with deferred Zidovudine therapy for asymptomatic HIV-infected adults with CD4 cell counts of 500 or more per cubic millimeter", The New England Journal of Medicine, 333:401-407.

Hammer SM, Squires KE, Hughes MD, et al. (1997). A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus and CD4 cell counts of 200 per cubic millimeter or less. New England Journal of Medicine; 337:725-733.

Kalish, L.A., Pitt, J., Lew, J., Landesman, S., Diaz, C., Hershow, R., Hollinger, F.B., Pagano, M. , Smeriglio, V., Moye, J. for the Women's and Infants Transmission Study (WITS). (1997). Defining the time of fetal or perinatal acquisition of human immunodeficiency virus type 1 infection on the basis of age at first positive culture. Journal of Infectious Diseases, 175:712-715.

Hughes MD, Johnson VA, Hirsch MS, et al. (1997). Monitoring HIV-1 RNA levels in plasma in addition to CD4+ lymphocyte count improves assessment of antiretroviral therapeutic response. Annals of Internal Medicine; 126:929-938.

Kahn, J., Lagakos, S.W., et al (1999). Efficacy and Safety of Adefovir Dipivoxil with Antiretroviral Therapy. J. Amer. Med. Assoc. 282(24): 2305-2312, December 22-29, 1999.

Sun, J., Liao, Q., and Pagano, M. (1999). Regression analysis of doubly interval censored failure time data with applications to AIDS. Biometrics, 55:909-914.

Bellocco, R., Xu, J. Schinaia, N., Arcieri R., and Pagano, M., (2000). Survival of patients with Blood-borne AIDS in Italy, Journal of Epidemiology and Biostatistics, 5:79-87.

Cheng, Debbie M. and Lagakos, S.W. (2000). Analysis of Data from Eradication Studies of Chronic Viral Infections. Biometrics, 56:626-633.

Kahn, J.O., Cherng, D.W., Mayer, K., Murray, H., and Lagakos, S.W. (2000). An Evaluation of HIV-1 Immunogen, an Immunologic Modifier, Administered to HIV-1 Infected People with 300-549 CD4+ T Cells: A Randomized, Controlled Study with Clinical Endpoints. J. American Medical Association, 284:2193-2202.

Balasubramanian, Raji and Lagakos, Stephen W. (2001). Estimation of the timing of perinatal transmission of HIV. Biometrics, 57:1048-1058.

Kowalski, J., Pagano, M. and DeGruttola, V. (2002). A Non-Parametric Test of Gene Region Heterogeneity Associated with Phenotype. Journal of the American Statistical Association, 97:398-408.

DiRienzo AG. (2003) Nonparametric Comparison of Two Survival Time Distributions in the Presence of Dependent Censoring, Biometrics, 59(3):497-507.

DiRienzo AG, DeGruttola V, Larder B and Hertogs K. (2003) Nonparametric methods to predict HIV drug susceptibility phenotype from genotype, Statistics in Medicine, 22:2785-98.

Jiang H, Chappell R, Fine JP. (2003) Estimating the Distribution of Nonterminating Event Times in the Presence of Mortality or Informative Dropout. Controlled Clinical Trial, 24:135-146.

Jiang H, Deeks SG, Kuritzkes DR, Lallemant M, Katzenstein D, Albrecht M, DeGruttola V. (2003) Assessing resistance costs of antiretroviral therapies via measures of Future Drug Options. Journal of Infectious Diseases, 188:1001-8.

Carey VJ, Yong FH, Frenkel LM, McKinney RM. (2004) Growth velocity assessment in paediatric AIDS: smoothing, penalized quantile regression and the definition of growth failure. Stat in Med, 23:509-526.

Ozonoff A, Forsberg L, Bonetti M, Pagano M. Bivariate method for spatio-temporal syndromic surveillance. MMWR Morb Mortal Wkly Rep. 2004 Sep 24;53 Suppl:59-66.

Carey VJ, Pahwa S, Weinberg A. (2005) Reliability of CD4 quantitation in HIV+ children: Implications for definition of immunological response to HAART. Clin Diag Lab Immunol, 12(5):640-3.

Jiang H, Fine JP, Kosorok M and Chappell R. (2005) Pseudo Self-Consistent Estimation of a Copula Model with Informative Censoring. Scandinavian Journal of Statistics, 32:1-20.

Tassiopoulos KK, Seage GR 3rd, Sam NE, Ao TT, Masenga EJ, Hughes MD, Kapiga SH. Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, Tanzania. AIDS Behav. 2006 Jul;10(4):405-13.

Tassiopoulos KK, Seage G 3rd, Sam N, Kiwelu I, Shao J, Ao TT, Essex M, Coplan P, Rosenberg Z, Hughes M, Kapiga S. Predictors of herpes simplex virus type 2 prevalence and incidence among bar and hotel workers in Moshi, Tanzania. J Infect Dis. 2007 Feb 15;195(4):493-501. Epub 2007 Jan 4.

Tassiopoulos K, Williams PL, Seage GR 3rd, Crain M, Oleske J, Farley J; International Maternal Pediatric Adolescent AIDS Clinical Trials 219C Team. Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):607-14. PMCID: PMC3089963

Ozonoff A, Jeffery C, Manjourides J, White LF, Pagano M. Effect of spatial resolution on cluster detection: a simulation study. Int J Health Geogr. 2007 Nov 27;6:52. PMCID: PMC2213641

Olives C, Pagano M, Deitchler M, Hedt B, Egge K, and Valadez JJ. Cluster designs to assess the prevalence of acute malnutrition by lot quality assurance sampling: a validation study by computer simulation. Journal of the Royal Statistics Society, Series A. 2009;172: 495-510. PMCID: PMC2784900

Jeffery C, Ozonoff A, White LF, Nuño M, Pagano M. Power to detect spatial disturbances under different levels of geographic aggregation. J Am Med Inform Assoc. 2009 Nov-Dec;16(6):847-54. Epub 2009 Aug 28. PMCID: PMC3002119

Novitsky V, Woldegabriel E, Kebaabetswe L, Rossenkhan R, Mlotshwa B, Bonney C, Finucane M, Musonda R, Moyo S, Wester C, van Widenfelt E, Makhema J, Lagakos S, Essex M. Viral Load and CD4+ T-Cell Dynamics in Primary HIV-1 Subtype C Infection. J Acquir Immune Defic Syndr. 2009; 50(1): 6576. PMCID: PMC2701379

Lahariya C, Sudfeld CR, Lahariya D, Tomar SS. Causes of child deaths in India, 1985-2008: a systematic review of literature. Indian J Pediatr. 2010 Nov;77(11):1303-11.

McDaniel S, Minnier J, Betensky RA, Mohapatra G, Shen Y, Gusella J, Louis D, Cai T. Assessing population level genetic instability via moving average. Statistics in Biosciences, 2010; 2(2):102-136.

Manjourides J, and Pagano M. Improving chronic disease surveillance by incorporating residential history. Statistics in Medicine. 2011 Aug 15;30(18):2222-33. PMCID: PMC3133828

Claggett B, Lagakos S, Wang R. Augmented cross-sectional studies with abbreviated follow-up for estimating HIV incidence. Biometrics. 2011 Jun 13. doi: 10.1111/j.1541-0420.2011.01632.x. [Epub ahead of print]. PMCID: PMC3182305

Martin CR, DaSilva DA, Cluette-Brown JE, DiMonda C, Hamill A, Bhutta AQ, Coronel E, Wilschanski M, Stephens AJ, Driscoll DF, Bistrian BR, Ware JH, Zaman MM, Freedman SD. Decreased Postnatal Docosahexaenoic and Arachidonic Acid Blood Levels in Premature Infants Increase the Risk of Neonatal Morbidities. J Pediatr. 2011 Nov;159(5):743-749.

Friedman K, Salvin J, Wypij D, Gurmu Y, et al., Risk factors for failed staged palliation after bidirectional Glenn in the recent era. European Journal of Cardio-Thoracic Surgery. 2011 Oct;40(4):1000-6. PMCID: PMC3376531

Minnier J, Tian L, and Cai T (2011). A perturbation method for inference on regularized regression estimates. J Am Stat Assoc. 2011 Jan 1;106(496):1371-1382. Epub 2012 Jan 24. PMCID: PMC3404855

Perlis RH, Iosifescu DV, Castro VM, Murphy SN, Gainer VS, Minnier J, Cai T, Goryachev S, Zeng Q, Gallagher PJ, Fava M, Weilburg JB, Churchill SE, Kohane IS, and Smoller JW. Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model. Psychol Med. 2012 Jan;42(1):41-50. Epub 2011 Jun 20.

Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, Ambudkar SV, Gottesman MM. Irrelevance of Established Cancer Cell Lines to the Study of Clinical Anti-cancer Drug Resistance. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18708-13. PMCID: PMC3219108

Sacks GD, Panchmatia JR, Marino M, Hill C, Rogers S. The Effect of Operative Timing on Functional Outcome After Isolated Spinal Trauma. J Trauma. 2011 Dec;71(6):1668-1672. PMCID: PMC Journal in Process.

Stephens AJ, Tchetgen Tchetgen EJ, De Gruttola V (2012). "Augmented GEE for improving efficiency and validity of estimation in cluster randomized trials by leveraging cluster- and individual-level covariates." Statistics in Medicine. In press