Interdisciplinary Grant in Biostatistics




James Signorovitch (2002-2007) is currently an Associate / Manager at the Analysis Group Inc. (Health Field Division), Boston, MA.

Publications while in training include:

Sadow, CA; Silverman, SG; O'Leary, MP, Signorovitch JE. "Bladder cancer detection with CT urography in an academic medical center" Radiology, 2008; 249(1): 195-202. (PMID: 18796677).

Moukarbel, GV; Signorovitch, JE; Pfeffer, MA, et al. "Risk factors for gastrointestinal bleeding in post-myocardial infarction patients: Results from the VALIANT trial", Journal of the American College of Cardiology, 2008; 51(10) A248-A248.

Thune, JJ; Signorovitch, J; Kober, L, et al. "Response to the J-point revisited", Hypertension, 2008; 51(5): E35-E35.

Thune JJ, Signorovitch J, Kober L, Velazquez EJ, McMurray JJ, Califf RM, Maggioni AP, Rouleau JL, Howlett J, Zelenkofske S, Pfeffer MA and Solomon SD. Effect of antecedent hypertension and follow-up blood pressure on outcomes after high-risk myocardial infarction. Hypertension, 2008; 51(1): 48-54.

Asselbergs FW, van den Berg MP, Bakker SJ, Signorovitch JE, Hillege HL, van Gilst WH and van Veldhuisen DJ. N-terminal pro B-type natriuretic peptide levels predict newly detected atrial fibrillation in a population-based cohort. Neth Heart J, 2008; 16(3): 73-8. (PMCID: PMC2266866).

Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T and Weitz CJ. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell, 2007; 130(4): 730-41.

Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T and Weitz CJ. Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol, 2007; 72: 307-18. (PMID: 18419288).

Karlson EW, Watts J, Signorovitch J, Bonetti M, Wright E, Cooper GS, McAlindon TE, Costenbader KH, Massarotti EM, Fitzgerald LM, Jajoo R, Husni ME, Fossel AH, Pankey H, Ding WZ, Knorr R, Condon S and Fraser PA. Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project. Arthritis Rheum, 2007; 56(1): 244-54. (PMID: 17195228).

Patrick Loerch (2003-2008) is currently Director of Health Informatics at Merck & Co., Inc., San Francisco, CA.

Publications while in training include:

Loerch P, Lu T, Dakin KA, Vann JM, Isaacs A, et al. "Evolution of the Aging Brain Transcriptome and Synaptic Regulation." PLoS ONE, 2008; Oct 2;3(10):e3329 (PMID: PMC2553198).

Yankner B, Lu T, and Loerch P. "The Aging Brain."Annual Review of Pathology: Mechanisms of Disease, 2008; 3:41-66. (PMID: 18039130).

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW and Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell, 2008; 135(5): 907-18. (PMCID: PMC2853975).

Michael Wu (2004-2009) is currently Assistant Professor of Biostatistics at the University of North Carolina at Chapel Hill, Chapel Hill, NC.

Publications while in training include:

Wu MC, Zhang L, Wang Z, Christiani DC and Lin X. Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection. Bioinformatics, 2009; 25(9): 1145-51. (PMCID: PMC2732305.)

Huang YT, Heist RS, Chirieac LR, Lin X, Skaug V, Zienolddiny S, Haugen A, Wu MC, Wang Z, Su L, Asomaning K and Christiani DC. Genome-Wide Analysis of Survival in Early-Stage Non-Small-Cell Lung Cancer. J Clin Oncol, 2009. (PMCID: PMC2690391.)

Engbring, J.A., Hossain, R., VanOsdol, S.J., Kaplan-Singer, B., Wu, M, Hibino, S., Koblinski, JE. "The laminin alpha-1 chain derived peptide, AG73, increases fibronectin levels in breast and melanoma cancer cells". Clinical and Experimental Metastasis, 2008; 25(3):241-52. Epub 2008 Jan 10. (PMID: 18185912).

Wu, M, Cai, T, Lin, X. "A parametric permutation test for regression coefficients in LASSO regularized regression." Submitted to Journal of the American Statistical Association.

Harezlak J, Wu MC, Wang M, Schwartzman A, Christiani DC and Lin X. Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data. J Proteome Res, 2008; 7(1): 217-24. (PMID: 18173220).

Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE and Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature, 2007; 448(7155): 807-10. (PMID: 17676035).

Keith Betts (2005-2010) is currently an Associate at Analysis Group Inc. (Health Field Division), Boston, MA.

Publications while in training include:

Alm El-Din MA, Hughes KS, Finkelstein DM, Betts KA, Yock TI, Tarbell NJ, Aisenberg AC, Taghian AG. "Breast Cancer After Treatment of Hodgkin's Lymphoma: Risk Factors that Really Matter." Int J Radiat Oncol Biol Phys, 2008; 69(3):S27. (PMID: 18538497).

Betts KA, Harrington DP. "Prediction and Misclassification in Right-censored Time-to-Event Data." Submitted to Life Time Data Analysis, 2008.

Jessie Hsu (2006-2012) is currently in a summer position as a Data Scientist Intern at Redfin in Seattle, WA.

Publications while in training include:

Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR. "B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma." American Journal of Surgical Pathology, 2010 Mar; 34(3):327-40. (PMCID: PMC3152212).

Atkins MB, Hsu J, Lee S, Cohen GI, Flaherty LE, Sosman JA, Sondak VK, Kirkwood JM. "Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Alone in Patients With Metastatic Malignant Melanoma (E3695): A Trial Coordinated by the Eastern Cooperative Oncology Group". Journal of Clinical Oncology 2008 26(35) 5748-5754. (PMCID: PMC2645104).

Jessica Larson (2007-2012) is currently a Computational Biologist at Genentech, Inc., South San Francisco, CA.

Publications while in training include:

Larson JL, Yuan GC. Chromatin states accurately predict cell differentiation status. PLoS One. 2012;7(2):e31414. Epub 2012 Feb 20. (PMCID: PMC3282719).

Larson, JL, Yuan GC. Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model. BMC Bioinformatics. 2010 Nov 12;11:557. (PMCID: PMC 2992069).

Sihai Dave Zhao (2007-2012) is currently a Research Fellow at the University of Pennsylvania Perelman School of Medicine, Department of Biostistics and Epidemiology, Philadelphia, PA.

Publications while in training include:

Zhao SD. Sure screening for estimating equations in ultra-high dimensions. J Am Stat Assoc. 2011, Submitted.

Zhao SD, and Li Y. Principled sure independence screening for Cox models with ultra-high-dimensional covariates. J Multivar Anal. 2012 Feb 1;105(1):397-411. (PMCID: PMC3293491 [Available on 2013/2/1]).

Goguen LA, Chapuy CI, Li Y., Zhao SD, Annino DJ. Neck dissection after chemoradiation – timing and complications. Arch Otolaryngol Head Neck Surg. 2010;136(11):1071-1077. (

Stryjewski, T. P., Benadretti, D. B., Zhao, S. D., Rowe, S., and Mitnick, C. D., "Preliminary clinical outcomes from the Peruvian National Cataract Elimination Plan". Rev Panam Salud Publica. 2010 Oct;28(4):282-8. (PMID: 21152716).

Zhao, S. D. and Li, Y. A note on optimal weights and variable selections for multivariate survival data. Science in China Series A, 2009; 52, 1131–1133.

Janket, SJ, Bollu, P, Zhao, SD. "Questionable performance of a questionnaire" Journal of Dental Research, 2008; 87(10): E1-E1.

Layla Parast (2007-2012) is currently an Associate Statistician with Rand Corporation, Santa Monica, CA.

Publications while in training include:

Parast L, Cheng S, Cai T. Landmark Prediction of Long Term Survival Incorporating Short Term Event Time Information. Submitted.

Parast L, Cai T. Landmark Risk Prediction for Breast Cancer Survival. Submitted.

Lu MT, Demehri S, Cai T, Parast L, Hunsaker AR, Goldhaber SZ, Rybicki FJ. Axial and reformatted 4-chamber RV/LV diameter ratios on CT pulmonary angiography as predictors of death after acute pulmonary embolism. AJR Am J Roentgenol. 2012 Jun;198(6):1353-60. (PMID: 22623548).

Parast L, Cheng SC, Cai T. Incorporating short-term outcome information to predict long-term survival with discrete markers. Biom J. 2011 Mar;53(2):294-307. doi: 10.1002/bimj.201000150. Epub 2011 Feb 21. (PMID: 21337601).

Qi L, Parast L, Powers C, Cai T, Hu FB, Doria A. Genetic Susceptibility to Coronary Heart Disease in Type 2 Diabetes: Three Independent Studies. J Am Coll Cardiol. 2011 Dec 13;58(25):2675-82. [Received the American Diabetes Association Michaele Modan Memorial Award, June 2010.] (PMCID: PMC3240896 [Available on 2012/12/13]).