Interdisciplinary Grant in Biostatistics
 


Directors & Preceptors

Careers






Co-Directors

Xihong Lin, PhD; Professor of Biostatistics and Coordinating Director of the newly established HSPH Program of Quantitative Genomics (PQG). Dr. Lin is a leading expert in statistical methods for correlated and high-dimensional data arising from "omics" and observational studies. Examples of correlated data include longitudinal, clustered, and hierarchical data which often arise in observational studies and clinical trials. Examples of high-dimensional data include genomic, epigenomic, and proteomic data. Her statistical methodological research is currently supported by an NCI MERIT (Method to Extend Research in Time) Award entitled "Statistical Methods for Correlated and High-Dimensional Biomedical Data". She is the PI of a P01 grant from the NCI entitled "Statistical Informatics in Cancer Research," the co-PI of the HSPH Gene and Environment training grant jointly supported by the NIEHS and NHGRI, and the co-PI of the Environmental Statistics training grant. She serves on the steering committee of the HSPH Gene and Environment Initiative. She was the coordinating editor of Biometrics, a leading biostatistical journal, and is currently the founding co-editor of the new journal Statistics in Biosciences.

Dr. Lin's specific areas of statistical expertise include statistical genetics, genomics and "omics", statistical methods for high-dimensional data, nonparametric and semiparametric regression methods, measurement error, mixed models and estimating equations, missing data, multiple outcomes, survival analysis for correlated data, and statistical methods for epidemiology. Dr. Lin's areas of applications include genetic and environmental epidemiology, chronic diseases such as cancer, cardiovascular disease, asthma and lung diseases, and biomarkers. Dr. Lin has collaborated extensively with molecular and genetic epidemiologists, environmental health scientists at HSPH, and basic and clinical scientists at Harvard Medical School and Dana-Farber Cancer Institute. She has been engaged in studying genetic effects and gene-environment interactions using both candidate genes and GWAS in lung cancer, biomarker discovery for lung and prostate cancers using mass-spectrometry and protein arrays, and pathway analysis using microarrays for environmental exposures. Her research team published the first GWAS for investigating the associations of tissue SNPs and CNVs with lung cancer survival. She is the leading statistician of an ongoing large scale GWAS for lung cancer survival using germlines. She is also leading the analysis of an epigenomic study using a genome-wide DNA methylation scan for cardiovascular diseases and gene and environment effects using data from the Normative Aging Study.

John Quackenbush, PhD; Professor of Computational Biology and Bioinformatics in the Department of Biostatistics, and co-Director (with Drs. Lin and Hunter) of the PQG at the Harvard School of Public Health. He is also Professor of Biostatistics and Computational Biology and Professor of Cancer Biology, as well as Director of the Center for Cancer Computational Biology at the Dana-Farber Cancer Institute. Dr. Quackenbush is a world leader in Computational Biology, Bioinformatics, and Genomics, and the application of these disciplines to the study of human disease. Originally trained in Theoretical Physics and Experimental High Energy Physics, Dr. Quackenbush made the transition to biomedical research in 1992 with the help of a Special Emphasis Research Career Award (SERCA) from the (then) National Center for Human Genome Research. Before joining the faculty in the Department of Biostatistics at HSPH in 2005, he worked at the Salk Institute for Biological Studies, the Stanford Human Genome Center at Stanford University, and The Institute for Genomic Research (TIGR).

Dr. Quackenbush's work has focused on the application of genomics and bioinformatics to the study of a wide range of problems with a focus on human disease, including cancer. His work is supported by grants from the National Science Foundation for analysis of gene sequences in plants, from the National Library of Medicine for the development of methods and software for gene expression analysis, and from the National Human Genome Research Institute for the study of how viruses perturb cellular networks. He has a Claudia Barr Adams award for the analysis of gene expression profiles to understand the problem of platinum therapy resistance in ovarian cancer, and is an investigator on numerous SPORE projects. He was recently awarded a EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration) R01 from the NLM to use full-text mining of PubMed and Bayesian Network Analysis to build predictive models from gene expression data.

Executive Committee

Xihong Lin, PhD; Professor of Biostatistics.

John Quackenbush, PhD; Professor of Computational Biology and Bioinformatics.

Peter Kraft, PhD; Associate Professor of Epidemiology.

Winston Hide, PhD; Associate Professor of Bioinformatics and Computational Biology.

Marianne Wessling-Resnick, PhD; Professor of Nutritional Biochemistry.

Christoph Lange, PhD; Associate Professor of Biostatistics.

Tianxi Cai, ScD; Associate Professor of Biostatistics.


PRECEPTORS

Rebecca Betensky, PhD; Professor of Biostatistics.

Myles Brown, MD; Professor of Medicine.

Martha Bulyk, PhD; Associate Professor of Medicine and Pathology.

Tianxi Cai, ScD; Associate Professor of Biostatistics.

Lynda Chin, MD; Professor of Dermatology.

David Christiani, MD; Elkan Blout Professor of Environmental Genetics / Professor of Medicine.

Victor DeGruttola, ScD; Professor and Chair of Biostatistics.

Winston Hide, PhD; Associate Professor of Bioinformatics and Computational Biology.

Gökhan Hotamisligil, PhD, MD; J.S. Simmons Professor of Genetics and Metabolism / Chair of Genetics and Complex Diseases.

David Hunter, ScD; Dean for Academic Affairs and Vincent L. Gregory Professor in Cancer Prevention.

Curtis Huttenhower, PhD; Assistant Professor of Computational Biology and Bioinformatics.

Issac Kohane, MD, PhD; Lawrence J. Henderson Professor of Pediatrics.

Peter Kraft, PhD; Associate Professor of Epidemiology.

Nan Laird, PhD; Professor of Biostatistics.

Christoph Lange, PhD; Associate Professor of Biostatistics.

Charles Lee, PhD; Associate Professor of Pathology.

Cheng Li, PhD; Associate Professor of Biostatistics.

Jun Liu, PhD; Professor in the Department of Biostatistics.

Xiaole Liu, PhD; Associate Professor of Biostatistics.

Jarrod Marto, PhD; Assistant Professor of Biological Chemistry and Molecular Pharmacology.

Peter Park, PhD; Assistant Professor of Pediatrics.

Alkes Price, PhD; Assistant Professor of Statistical Genetics.

John Quackenbush, PhD; Professor of Computational Biology and Bioinformatics.

Marco Ramoni, PhD; Associate Professor of Pediatrics and Medicine.

James Robins, MD; Mitchell L. and Robin LaFoley Dong Professor of Epidemiology.

Frederick Roth, PhD; Associate Professor of Biological Chemistry and Molecular Pharmacology.

Edwin Silverman, MD, PhD; Associate Professor of Medicine.

Shamil Sunyaev, PhD; Assistant Professor of Medicine and Health Sciences and Technology.

Marc Vidal, PhD; Associate Professor of Genetics.

James Ware, PhD; Frederick Mosteller Professor of Biostatistics.

Lee-Jen Wei, PhD; Professor of Biostatistics.

Scott Weiss, MD; Professor of Medicine.

Marianne Wessling-Resnick, PhD; Professor of Nutritional Biochemistry.

Ting Wu, PhD; Professor of Genetics.

Guocheng Yuan, PhD; Assistant Professor of Computational Biology and Bioinformatics.