Ph.D., 2012, MRC-PPU, University of Dundee, Scotland, UK
B.S., 2008, Bogazici University, Istanbul, Turkey.
Gerta is interested in understanding how oncogenic activation of signaling pathways, which results in abnormal cell proliferation and cancer, alters the metabolic reprogramming of cells. She is focused on identifying critical metabolic enzymes that could potentially be exploited for cancer therapy.
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014 Feb 13; 156(4): 771-85. PMID: 24529379
Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J Cell Sci. 2012. 125: 4662-75. PMID: 22797923
Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N. MENA is a transcriptional target of the Wnt/beta-catenin pathway. PLoS One. 2012. 7: e37013. PMID: 22615875
Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal. 2010. 22: 1523-35. PMID: 20538055
Jeong JY, Hoxhaj G, Socha AL, Sytkowski AJ, Feldman L. An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells. Mol Cancer Res. 2009. 7: 1150-7. PMID: 19567780