Hui Zhang

Hui Zhang OLYMPUS DIGITAL CAMERA

Current Position: Clinical Development Manager, Biomedical Valley Discoveries

Postdoctoral Fellow: 2005-2008

Hui was supported by a Postdoctoral Fellowship from the LAM Foundation while a member of the Manning Lab.

Select Publications: 

Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012. 5(217):ra24. PMID: 22457330

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 2011. 14(1):21-32. PMID: 21723501

Zhang HH, Huang J, Duvel K, Boback B, Wu S, Squillace RM, Wu CL, and Manning BD. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One. 2009. 4(7):e6189. PMID: 19593385

Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 24(2):185-97. PMID: 17052453

Zhang HH, Souza SC, Muller KV, Kraemer FB, Obin MS, Greenberg AS. 2003 Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis. J Biol Chem. 2003. 278(51):51535-42. PMID: 14527948

Zhang HH, Halbleib M, Ahmad Faiyaz, Manganiello VC, Greenberg AS. Tumor necrosis factor alpha stimulates lipolysis in differentiated human adiposities through activation of extra cellular signal-related kinase and elevation of intracellular camp. Diabetes. 2002. 51(10):2929-35. PMID: 12351429

Zhang HH, Ego MC, Barnett AH, Kumar S. Dexamethasone inhibits tumor necrosis factor alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adiposities and preadipocytes. J Clin Endocrinol Metab. 2001. 86(6):2817-25. PMID: 11397893

Zhang HH, Eggo MC, Barnett AH, Kumar S. Tumor necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and release. Mol Cell Endocrinol. 2006. 159 (1-2): 79-88. PMID: 10687854

Zhang HH, Eggo MC, Barnett AH, Kumar S. Ceiling culture of mature human adiposities: use in studies of adiposity functions. J Endocrinol. 2000. 164(2):119-28. PMID: 10657847

Zhang HH, Kumar S, Barnett AH, Eggo MC. Intrinsic site-specific differences in the expression of leptin in human adiposities and its anticrime effects on glucose uptake. J Clin Endocrinol Metab. 1999. 84(7):2550-6. PMID: 10404835