Ph.D., 2009, Rockefeller University
B.A., 2004, University of Pennsylvania
Research Interests: Jessica is interested in using mouse models and in vitro methods to elucidate the layers of regulation that govern cellular functions, particularly those relevant to metabolic disease. She is investigating metabolic changes induced by mTOR signaling and is exploring the role of mTOR repression in ameliorating the diabetic phenotype.
Her research is supported, in part, by a fellowship from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health.
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013 Aug 1;41(4):906-12. doi: 10.1042/BST20130041. PMID: 23863154
Ben-Sahra I*, Howell JJ*, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15;339(6125):1323-8. PMID: 23429703. *Co-1st authors.
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012 Mar 27;5(217):ra24. PMID: 22457330
Howell JJ and Manning BD. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab 2011; 22:94-102.
Silva JP, Howell J, von Meyenn F, Thorens B, Wolfrum C, Stoffel M. Regulation of adaptive behavior during fasting by hypothalamic Foxa2. Nature. 2009 Dec 3; 462(7273): 646-50.
Howell JJ, Stoffel M. Nuclear export-independent inhibition of Foxa2 by insulin. J Biol Chem. 2009 Sep 11; 284(37):24816-24.
Wolfrum C, Howell JJ, Ndungo E, Stoffel M. Foxa2 Activity Increases Plasma High Density Lipoprotein Levels by Regulating Apolipoprotein M. J Biol Chem. 2008 Jun 13; 283(24):16940-16949.
Arsham AM, Howell JJ, Simon MC. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem. 2003 Aug 8; 278(32):29655-60.