Jessica Lucas Yecies

Jessica Lucas Yecies JessicaYecies_HaberAward

Current Position: Competitive Intelligence Manager in the BioOncology group (Genentech)

Graduate Student: 2008-2012

Education:  B.S., 2008, Princeton University

Research Interests: Jess is interested in the effects of mTOR signaling on cellular metabolic pathways, with an emphasis on the control of de novo lipid synthesis through the SREBP transcription factor.  Her research is geared toward revealing novel therapeutic approaches for mTOR-driven pathological states, including tumor syndromes, cancer, and metabolic diseases.


Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 2015 Jun 1. doi: 10.1038/onc.2015.179. PMID: 26028026

Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012. 5(217):ra24. PMID: 22457330

De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011. 20(3):400-13. PMID: 21907929

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 2011. 14(1):21-32. PMID: 21723501

Yecies JL, Manning BD. Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res. 2011 Apr 15;71(8):2815-20. Epub 2011 Apr 12. PMID: 21487041

Yecies JL, Manning BD. mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med (Berl). 2011. 89(3):221-8. PMID: 21301797

Düvel K*, Yecies JL*, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010. 39(2):171-83. PMID: 20670887. Co-1st Authors*

Yecies JL, Manning BD. Chewing the fat on tumor cell metabolism. Cell. 2010. 140(1):28-30. PMID: 20085702