Katrin Duvel

Katrin Duvel Katrin

Current Position: Research Scientist, Belfer Institute for Applied Cancer Science

Postdoctoral Fellow: 2006-2010

Research Interest:

Katrin is interested in the regulation and function of TOR signaling pathways in yeast and mammalian systems. Her current research focuses on transcriptional changes that are caused by loss of the Tsc genes and are dependent on the constitutive activation of the mTOR complex 1.

Katrin’s research is funded by a Postdoctoral Fellowship from the Tuberous Sclerosis Alliance.

Selected Publications:

Düvel K, Yecies JL, Menon S, Raman P, Lipovsky, AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. 2010. Mol Cell. 39(2):171-83. PMID: 20670887

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, and Manning BD. Insulin stimulates adipogenesis through theAkt-TSC2-mTORC1 pathway. 2009. PLoS One. 4(7):e6189. PMID: 19593385

Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, and Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. 2008. Mol Cell. 29(5): 541-51. PMID: 18342602

Schneper L, Düvel K., Broach JR. Sense and Sensibility: Nutritional Response and Signal Integration in Yeast. 2004. Curr Opin Microbiol. 7(6):624-30. PMID: 15556035

Santhanam A, Hartley A, Düvel K, Broach JR, Garrett, S. PP2A phosphatase activity is required for stress- and Tor-regulation of yeast stress response factor, Msn2p. 2004. Eukaryot Cell. 3(5):1261-71. PMID: 15470255

Düvel K, Broach JR. The role of phosphatases in TOR signaling in yeast. 2004. Curr Top Microbiol Immunol. 279: 19-38. PMID: 14560949

Düvel K, Santhanam A, Garrett S, Schneper L, Broach JR. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. 2003. Mol Cell. 11(6): 1467-78. PMID: 12820961