Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15;339(6125):1323-8. PMID: 23429703.
Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013 Mar 1;14(3):242-51. PMID: 23399656
Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, and Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24;47(4):535-46. PMID: 22795129.
Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, and Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell 2012; July 20 [Epub ahead of print].
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. (2012) Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012 Mar 27;5(217).
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, and Manning BD. (2011) Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metabolism 14, 21-32.
Yecies, JL and Manning, BD. (2011) Transcriptional control of cellular metabolism by mTOR signaling. Cancer Research 71, 2815-20.
Howell, JJ and Manning, BD. (2011) mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends in Endocrinology and Metabolism 22, 94-102.
Manning, BD. (2010) Insulin Signaling: Inositol phosphates get into the Akt. Cell 143, 861-63.
Duvel K, Yecies JL, Menon S, Raman P, Lipovsky, AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell 39, 171-183.
Yecies, J.L. and Manning, B.D. (2010) Chewing the fat on tumor cell metabolism. Cell 140, 28-30.
Dibble, C.C., Asara, J., and Manning, B.D. (2009) Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Molecular and Cellular Biology 29, 5657-70.
Dibble, C.C. and Manning, B.D. (2009) A molecular link between Akt regulation and chemotherapeutic response. Cancer Cell 16, 178-80.
Zhang, H.H., Huang, J., Duvel, K., Boback, B., Wu, S., Squillace, R.M., Wu, C.L., and Manning, B.D. (2009) Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 4, e6189.
Manning, B.D. (2009) Challenges and opportunities in defining the essential cancer kinome. Science Signaling 2, pe15.
Huang, J., Wu, S., Wu, C.L., and Manning, B.D. (2009) Signaling events downstream of mTOR complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Research 69, 6107-14.
Menon, S. and Manning, B.D. (2009) Common corruption of the mTOR signaling network in human tumors. Oncogene 27, S43-51.
Huang, J., Dibble, C.C., Matsuzaki, M., and Manning, B.D. (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Molecular and Cellular Biology 28, 4104-4115.
Huang, J. and Manning B.D. (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochemical Journal 412, 179-90.
Ozcan, U., Ozcan, L., Yilmaz, E., Duvel, K., Sahin, M., Manning, B.D., and Hotamisligil, G.S. (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell 29, 541-551.
Manning, B.D. and Cantley, L.C. (2007) AKT/PKB signaling: Navigating downstream. Cell 129, 1261-1274.
Zhang, H.H., Lipovsky, A.I., Dibble, C.C., Sahin, M., and Manning, B.D. (2006) S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Molecular Cell 24, 185-197.
Manning, B.D., Logsdon, M.N., Lipovsky, A.I., Abbott, D., Kwiatkowski, D.J., and Cantley, L.C. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking TSC2. Genes & Development 19, 1773-1778.
Manning, B.D. (2004) Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis. Journal of Cell Biology 167, 399-403.
Manning, B.D. and Cantley, L.C. (2003) Rheb fills a GAP between TSC and TOR. Trends in Biochemical Sciences 28, 573-576.
Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. and Cantley, L.C. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Molecular Cell 10, 151-162.6.