B.S. 2010, Massachusetts Institute of Technology, Cambridge, MA
Stéphane is interested in the effects oncogenic events have on cellular metabolism. He is focused on identifying and targeting changes in lipid metabolism in cancer settings in which mTORC1 is activated.
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014. doi: 10.1038/nature13492. PMID: 25043031
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013 Aug 1;41(4):906-12. doi: 10.1042/BST20130041. PMID: 23863154
Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013 Mar 1;14(3):242-51. PMID: 23399656
Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1a and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30:2986-96.