Stéphane Ricoult

2011_stephaneGraduate Student:

2010 –


B.S., 2010, Massachusetts Institute of Technology, Cambridge, MA

Research Interest:

Stéphane is interested in the effects oncogenic events have on cellular metabolism. He is focused on identifying and targeting changes in lipid metabolism in cancer settings in which mTORC1 is activated.


Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 2015 Jun 1. doi: 10.1038/onc.2015.179. PMID: 26028026

Priolo C, Ricoult SJ, Khabibullin D, Filippakis H, Yu J, Manning BD, Clish C, Henske EP. Tuberous Sclerosis Complex 2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2015 Jul;53(1):33-41. doi: 10.1165/rcmb.2014-0379RC. PMID: 25780943

Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014. doi: 10.1038/nature13492. PMID: 25043031

Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013 Aug 1;41(4):906-12. doi: 10.1042/BST20130041. PMID: 23863154

Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013 Mar 1;14(3):242-51. PMID: 23399656

Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1a and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30:2986-96.