Sue Menon

Sue (Sue.jpg)

Current Position: Research Investigator, Novartis

Postdoctoral Fellow: 2008-2013

Education: Ph.D. 2008, Yale University

Research Interests:

Sue is interested in using mice as a model system to study and validate targets involved in human diseases. She is currently using mouse models to investigate pathways involving the products of the tumor suppressor genes TSC1 and TSC2 that are mutated in the disease Tuberous Sclerosis Complex (TSC).  Some of the areas her research is addressing are 1) the in vivo regulation of the TSC1-2 complex by upstream factors, such as Akt, 2) the physiological role of the TSC1-2 complex in different tissues, and 3) the genetic relationship between the TSC genes and other tumor suppressors.

Select Publications:

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014. Feb 13; 156(4): 771-85. PMID: 24529379

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013. Nov;15(11):1340-50. PMID: 24161930

Menon S, Manning BD. Cell signalling: nutrient sensing lost in cancer. Nature. 2013. Jun 27;498(7455):444-5. PMID: 23803840

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, and Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012. Aug 24;47(4):535-46. PMID: 22795129.

Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012. Mar 27;5(217):ra24. PMID: 22457330

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, and Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab.2011. 14(1):21-32. PMID: 21723501

Duvel K, Yecies JL, Menon S, Raman P, Lipovsky, AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010. 39(2):171-183. PMID: 20670887

Menon S and Manning BD. Common corruption of the mTOR signaling network in human tumors. Oncogene. 2008. 27 Supple 2:S43-51. PMID: 19956179

Menon S, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard Flavell & Ning Wei. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nat Immunol. 2007 Nov;8(11):1236-45. PMID: 17906629

Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation  accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003. Oct;23(19):6790-7. PMID: 12972599

Yang X*, Menon S*, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol. 2002. Apr 16;12(8):667-72.  *Co-1st author. PMID: 11967155