Current Position: Research Investigator, Novartis
Postdoctoral Fellow: 2008-2013
Education: Ph.D. 2008, Yale University
Sue is interested in using mice as a model system to study and validate targets involved in human diseases. She is currently using mouse models to investigate pathways involving the products of the tumor suppressor genes TSC1 and TSC2 that are mutated in the disease Tuberous Sclerosis Complex (TSC). Some of the areas her research is addressing are 1) the in vivo regulation of the TSC1-2 complex by upstream factors, such as Akt, 2) the physiological role of the TSC1-2 complex in different tissues, and 3) the genetic relationship between the TSC genes and other tumor suppressors.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov;15(11):1340-50. PMID: 24161930
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014 Feb 13; 156(4): 771-85. PMID: 24529379
Menon S, Manning BD. Cell signalling: nutrient sensing lost in cancer. Nature. 2013 Jun 27;498(7455):444-5. PMID: 23803840
Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, and Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012 Aug 24;47(4):535-46. PMID: 22795129.
Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal. 2012 Mar 27;5(217):ra24. PMID: 22457330
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, and Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 2011; 14:21-32.
Duvel K, Yecies JL, Menon S, Raman P, Lipovsky, AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell 2010 39:171-183.
Suchithra Menon and Brendan D. Manning. Common corruption of the mTOR signaling network in human tumors. Oncogene 2009 27:S43-51.
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard Flavell & Ning Wei. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nature Immunology 2007 Nov;8(11):1236-45.
Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N., Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation accumulation of p53 and cyclin E, and early embryonic death. Molecular and Cellular Biology 2003 Oct;23(19):6790-7.
Yang X*, Menon S*, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N., The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Current Biology 2002 Apr 16;12(8):667-72. *Co-1st author