Postdoctoral Fellow: 2010 – 2015
Ph.D. 2009 – University of Toronto, Canada
M.S. 2000 – Institute of Biophysics of Chinese Academy of Sciences, China
B.S. 1997 – Nankai University, China
Cancer cells are dramatically different from normal cells in their metabolic functions. Yinan’s research aims at identifying metabolic and stress response pathways that provide the most attractive intervention points for treating cancer. Armed with such knowledge, he is trying to target these pathways by screening chemical compounds in search of new classes of cancer therapeutics.
Zhang Y, Manning BD. mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle. 2015 Jul 3;14(13):2011-7. doi: 10.1080/15384101.2015.1044188. Epub 2015 May 27. PMID:26017155
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014. doi: 10.1038/nature13492. PMID: 25043031
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, de Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-kB pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov 1;1(6):524-538. PMID: 22145100
Zhang Y, Kozlov G, Pocanschi C, Brockmeier U, Ireland BS, Maattanen P, Howe C, Elliott T, Gehring K, Williams DB. ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules and it enhances peptide loading independently of its redox activity. J Biol Chem. 2009 Apr 10; 284 (15): 10160-73.
Zhang Y, Williams DB. Assembly of MHC class I molecules within the endoplasmic reticulum. Immunol Res. 2006; 35 (1-2): 151-62.
Zhang Y, Baig E, Williams DB. Functions of ERp57 in the folding and assembly of major histocompatibility complex class I molecules. J Biol Chem. 2006 May 26; 281 (21): 14622-31.
Hu K, Sun Y, Chen D, Zhang Y. The effect of lipid environment in purple membrane on bacteriorhodopsin. J Photochem Photobiol B. 2000 Nov; 58 (2-3): 163-9.
Zhang Y, Yang G, Hu K. The conformational and functional effect of biotin modification on purple membrane. ACTA Biophysica Sinica. 2000 16 (4): 797-800.