John B. Little Center for

Radiation Sciences & Environmental Health

Fourth Annual Symposium

October 12-13, 2001

“Radiation Damage to DNA:  Repair and Cellular Responses”

Harvard School of Public Health

677 Huntington Avenue

Kresge G1

Boston, MA  02115

Agenda

 

Friday, October 12

 

1:00 p.m.            Opening Lecture:  Dr. James L. German (Weill Medical College of Cornell University)

                        “Four Decades of  Bloom’s Syndrome”

 

Presentation of John B. Little Award in Radiation Sciences to Dr. German

Dr. Warren W. Nichols, (Merck Research Laboratories)

 

2:00-5:30 p.m. - SESSION I.   Clustered Damage and Complex Interactions

            S. James Adelstein, (HMS) Discussion Leader

 

·        John Ward (University of California , San Diego)

“The variety of radiation-induced DNA strand breaks"

·        Paul W. Doetsch (Emory University School of Medicine)

“Transcriptional mutagenesis in prokaryotic and eukaryotic systems"

·        Sankar Mitra (University of Texas Medical Branch, Galveston)

“Effects of oxidative stress on the dynamics of early repair enzymes for oxidative DNA damage in human cells”

 

·        Carol Prives (Columbia University)

5:30-7:30            Reception (HSPH)

Saturday, October 13

8:30 a.m.            Continental Breakfast

9:00-12:30 - SESSION II.            Mechanisms of  Double Strand Break Repair

Kathryn D. Held (MGH) Discussion Leader

 

·        Maria Jasin  (Memorial Sloan Kettering Cancer Center)

“Genomic integrity and double-strand break repair in mammalian cells”

 

·        Alan D. D’Andrea  (Dana Farber Cancer Institute)

“Interactions of the Fanconi anemia proteins and Brca1 in a common pathway”

·        Fred Alt (Harvard Medical School)

“Interplay between non-homologous end joining and cell cycle checkpoint pathways in normal development and tumor suppression”

 

·        Tom K. Hei (Columbia University)

“Radiation-induced genotoxic damage in mammalian cells: From cytoplasm to nucleus and the bystander phenomenon”

 

12:30-1:30      L U N C H

 

1:30-5:00 - SESSION  III.    Cell Responses to Radiation Damage

Bruce Demple, (HSPH) Discussion Leader

·       James E. Haber (Brandeis University)

“Adaptation and recovery following a single chromosome break”

 

·       George Iliakis (Thomas Jefferson University)

“Double-strand break repair and cellular responses”

 

·     John Petrini (University of Wisconsin)

“The Mre11 complex: linking DNA recombination and cell cycle regulation to the suppression of malignancy”

 

·        Carrolee Barlow (Salk Institute)

“Using ATM-deficient mice to study the role of  ATM in damage response pathways”

 

·        William F. Morgan (University of Maryland)

“Radiation-induced genomic instability and bystander effects: A little goes a long way”

 

General Discussion  (John B. Little, Moderator)

 

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