Cheng Li
Associate Professor of Biostatistics
Department of Biostatistics
Research
We develop analysis methods and software for high-throughput microarray and sequencing data, and apply these methods to cancer and neuroscience studies. We use gene expression arrays, SNP arrays, and microRNA platforms for integrative analysis of genomic alteration patterns in human diseases such as cancer. We also develop and maintain the dChip software for microarray analysis, which has been cited more than 1600 times.
Publications
Li C, Kim SW, Rai D, Bolla AR, Adhvaryu S, Kinney MC, Robetorye RS, Aguiar RC. Copy number abnormalities, MYC activity and the genetic fingerprint of normal B-cells mechanistically define the microRNA profile of DLBCL. Blood. 2009. 113(26):6681-90. (PubMed, GEO)
Avet-Loiseau H, Li C, Magrangeas F, Gouraud W, Charbonnel C, Harousseau JL, Attal M, Marit G, Mathiot C, Facon T, Moreau P, Anderson KC, Campion L, Munshi NC, Minvielle S. Prognostic Significance of Copy-Number Alterations in Multiple Myeloma. J Clin Oncol. 2009. 27(27):4585-90 (PubMed, PDF, GEO)
Li C. Automating dChip: toward reproducible sharing of microarray data analysis. BMC Bioinformatics. 2008; 9:231. (PubMed, PDF)
Li C, Beroukhim R, Weir BA, Winckler W, Garraway LA, Sellers WR, Meyerson M. Major copy proportion analysis of tumor samples using SNP arrays. BMC Bioinformatics. 2008; 9:204. (PubMed, PDF)
Loerch PM†, Lu T†, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PloS ONE. 2008; 3(10):e3329. (PubMed, Journal, PDF)
Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using Empirical Bayes methods. Biostatistics. 2007; 8(1):118-127 (PubMed, PDF, Software)
Beroukhim R†, Lin M†, Park Y, Hao K, Zhao X, Garraway LA, Fox EA, Hochberg EP, Mellinghoff IK, Hofer MD, Descazeaud A, Rubin MA, Meyerson M, Wong WH, Sellers WR*, Li C*. Inferring Loss-of-Heterozygosity From Tumor-only Samples Using High-Density Oligonucleotide SNP Arrays. PLoS Computational Biology. 2006; 2(5): e41. (PubMed, PDF)
Education
B.S. in Computer Science, 1995, Beijing Normal University, China
Ph.D. in Statistics, 2001, University of California at Los Angeles