Select Publications

Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Cell Metab. 2010 Dec 1;12(6):643-53.

Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. J Biol Chem. 2011 Jan 14;286(2):1237-47. Epub 2010 Nov 8.

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Qi L, Cornelis MC, Kraft P, Stanya KJ, Linda Kao WH, Pankow JS, Dupuis J, Florez JC, Fox CS, Paré G, Sun Q, Girman CJ, Laurie CC, Mirel DB, Manolio TA, Chasman DI, Boerwinkle E, Ridker PM, Hunter DJ, Meigs JB, Lee CH, Hu FB, van Dam RM; Meta-Analysis of Glucose and Insulin-related traits Consortium (MAGIC); Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Hum Mol Genet. 2010 Jul 1;19(13):2706-15. Epub 2010 Apr 23.

Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. Epub 2010 Jan 4.

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20021-6. Epub 2008 Dec 9.

Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D, Lee CH, Hu FB. Diabetes. 2008 Nov;57(11):3145-51. Epub 2008 Jul 22. 

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Cell Metab. 2008 Jun;7(6):485-95.

PPAR delta as a therapeutic target in metabolic disease. Reilly SM, Lee CH. FEBS Lett. 2008 Jan 9;582(1):26-31. Epub 2007 Nov 26. Review.