Christopher Hine

Research Fellow

Department of Genetics and Complex Diseases

Department of Genetics and Complex Diseases

655 Huntington Avenue
Building 2, Room 127
Boston, Massachusetts 02115

Education

Ph.D., University of Rochester School of Medicine and Dentistry (2011)

B.S., Youngstown State University (2004)

Research Interests

My major research interests lie in cellular and organismal hormetic responses stimulated by dietary intervention. Low levels of stress originating from reduced caloric intake, alterations in amino acid composition and short-term fasting have been previously shown to elicit resistance to larger stresses induced by ischemia, radiation as well as cancer chemotherapeutics. What are not completely understood are the signals, activation cascades and transcription factors needed to elicit the hormetic response. In my research, I study the roles Sirt3 and Nrf2 play in the dietary preconditioning stimulated hormetic response against ischemic reperfusion and ionizing radiation. An ultimate goal would be the development of a dietary regiment that would offer protection to patients and their organs as they undergo chemo- and radio-therapies as well as surgeries where blood flow is restricted for a prolonged period of time.

Selected Publications

Hine, C; Seluanov, A; Gorbunova, V. Rad51 Promoter Targeted Gene Therapy is Effective for in vivo Visualization and Treatment of Cancer. Molecular Therapy (Accepted 2011)

Mao, Z; Hine, C; Tian, X; Van Meter, M, Au, M; Vaidya, A; Seluanov, A; Gorbunova, V. SIRT6 promotes DNA repair under stress by activating PARP1. Science (2011)

Seluanov, A; Hine, C; Azpurua, J; Feigenson, M; Bozzella, M; Mao, Z; Catania, K Gorbunova, V. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proceedings of the National Academy of Science (2009)

Hine, C; Seluanov, A; Gorbunova, V. Use of the Rad51 promoter for targeted anti-cancer therapy. Proceedings of the National Academy of Science (2008)

Seluanov, A; Hine, C; Bozzella, M; Hall, A; Sasahara, T; Ribeiro, A; Catania, K; Presgraves, D; Gorbunova, V. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell (2008)

Gorbunova, V; Seluanov, A; Mao, Z; Hine, C. Changes in DNA repair during aging. Nucleic Acids Research (2007)

Seluanov, A; Chen, Z; Hine, C; Sasahara, T; Ribeiro, A Catania, K; Presgraves, D; Gorbunova, V. Telomerase activity coevolves with body mass, not lifespan. Aging Cell (2007)