Claudio Hetz

Adjunct Professor of Immunology and Infectious Diseases

Department of Immunology and Infectious Diseases

ER

Research

 Mission – This laboratory focuses on understanding the molecular basis of organelle stress and its relationship to pathological conditions affecting the nervous system, and the development of prototypic therapies to prevent this damage. Our laboratory is committed to the study of cellular strategies involved in adaptation to chronic endoplasmic reticulum (ER) stress. The ER has important cellular functions, highlighting its role as sophisticated machinery for protein folding and secretion. ER stress engages an integrated signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to cell death processes remain unknown and is a central subject of our research. We are currently developing a systematic approach to underscore the effects of targeting the UPR in several brain diseases involving protein misfolding using genetic manipulation of the pathway in mouse models in addition to develop gene therapy strategies to alleviate ER stress. Our laboratory is one of the most productive laboratories in Chile and currently funded by various national and international organizations.see www.hetzlab.clIn addition we are part of the Biomedical neuroscience Institute as a co-Director and Principal investigator, a multidisciplinary center for neuroscience that bridges 11 different laboratories (www.bni.cl). We also stablished the Neurounion Biomedical Foundation, the first non-profit private Foundation for biomedical research (www.neurounion.com).

 

Department of Immunology and Infectious Diseases

651 Huntington Avenue
Boston, MA 02115
Phone: 52-2-29786506 (Santiago, Chile)
www.hetzlab.cl

Positions

07/11-present  HARVARD SCHOOL OF PUBLIC HEALTH                BOSTON, USA.  Department of Immunology and Infectious Diseases. Adjunct Professor

07/11- present   UNIVERSITY OF CHILE, SANTIAGO, CHILE. Deputy Director, Biomedical Neuroscience Institute

03/10- present   UNIVERSITY OF CHILE, SANTIAGO, CHILE. Full Professor and Principal Investigator. Institute of Biomedical Sciences

01/07- 03/10   UNIVERSITY OF CHILE, SANTIAGO, CHILE. Assistant Professor and Principal Investigator. Institute of Biomedical Sciences

 

Education

08/05-12/07    HARVARD SCHOOL OF PUBLIC HEALTH                                  BOSTON, USA. Department of Immunology and Infectious Diseases. Postdoctoral Research Fellow. Regulation of the Unfolded Protein Response in the CNS. Advisor: Laurie H. Glimcher, M.D.

08/04-08/05    DANA-FARBER CANCER INSTITUTE,          BOSTON, USA. Department of Cancer Immunology & AIDS. Postdoctoral Research Fellow. Regulation of apoptosis by the BCL-2 protein family. Advisor: Stanley Korsmeyer, M.D.

03/00-07/04    SERONO PHARMACEUTICAL RESEARCH INST.       GENEVA, SWITZERLAND, Department of Neurobiology and University of Chile. PhD. In Biomedical Sciences.  Advisor: Claudio Soto, Ph.D.

 

Awards

2014                Selected by the LatinAmericanScience.Org and Qué Pasa magazine as one of the 30 more influencing scientist in Latin America.

2012                Awarded with the FEBS Anniversary Prize of the Gesellschaft für Biochemie und Molekularbiologie. IUBMB & FEBS meeting, Sevilla.2012           Awarded with a gift from the Christopher Reeve Spinal Cord Injury and Paralysis Foundation, USA.2011                Young investigator Awards, North American Spine Society, USA.
2008              Awarded with the Young Scientist Prize TWAS-ROLAC from the Latin-American Science Academy for the best young scientist in the region and the Caribbean.2008                The Eppendorf & Science Prize for Neurobiology, selected finalist by the editors of Science magazine as outstanding young scientist.
2008               Awarded with the “Cell Biology Society and Bios-Chile prize” as the best young scientist of Chile.
2004-2007                  Damon Runyon Cancer Research. Research fellowship for postdoctoral training in Stanley Korsmeyer’s laboratory at Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
2003                Herman Neimeyer Medal, Chilean Society of Biochemistry and Molecular Biology. Recognition as the best Ph.D. student in Biomedical Sciences of Chile,
2001                  Federal Swiss Confederation Scholarship for Ph.D. thesis at Serono Pharmaceutical Research Institute, Geneva, Switzerland.