Publications

Publications

PUBLICATIONS, REVIEWS AND BOOK CHAPTERS

 

Castillo K, Rojas-Rivera D., Lisbona F., Caballero B., Nassif M., Court F., Schuck S., Ibar C., Walter P., Sierralta J., Glavic A., and Hetz C. 2011. BAX inhibitor-1 regulates autophagy by controlling the IRE1/JNK branch of the unfolded protein response. EMBO J. in press

 Hetz C, Martino F, Rodriguez, and Glimcher LH. (2011). The Unfolded Protein Response: Integrating stress signals through the stress sensor IRE1a. . Physiological Reviews.  In press

 WoehlbierU.and Hetz C. (2011). Modulating stress responses by the UPRosome: A matter of life and death. Trends in Biochem Ssci (TiBS), 36(6):329-37.

 Nassif M. and Hetz C. (2011). Targeting autophagy in ALS: a complex mission. Autophagy, 7(4)*#

 Torres M., Matus S., Arminsen R., Stitzin A., Soto C., and Hetz C. (2010). Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress. PlosOne. 5: e15658- e15658 *#

 Matus S., Glimcher LH., and Hetz C.  (2011). Protein folding stress in neurodegenerative diseases: a glimpse into the ER.  Curr Op. Cell Biol. 23:239-52. *#

 Hetz C. and Glimcher LH. (2011) Protein homeostasis networks in physiology and disease. Curr Op. Cell Biol. Editorial Overview. 23:123-5. *#

 Torres M., Encina G., Soto C., and Hetz C. (2011). Abnormal calcium homeostasis and protein folding stress at the ER: a common factor in familial and infectious Prion disorders. Commun Integr Biol. In press. *#

 Rodriguez D., Rojas D., and Hetz C. (2011).  The Endoplasmic Reticulum Gateway of Death. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research. 1813:564-74. *#

 Barrientos S.A., Martinez N.W., Yoo S., Jara, J.S., Zamorano S, Hetz, C., Twiss J.L. Alvarez J., Court F. A. (2011) Axonal degeneration is mediated by the mitochondrial permeability transition pore. J. Neurosci. 31:966-978. *#

 Klein A, Maldonado C., Vargas L., Robledo F., Perez de Arce K., Muñoz F., Hetz C., and Alvarez A. (2011). Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons Corresponding Neurobiol Dis.  41:209-18.

 Vidal R., Caballero B., Couve A., and Hetz C. (2011). Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington’s disease. Curr. Mol. Med. 11:1-12 (Cover illustration) *#

 Paula-Lima A, T. Adasme, A. Sebollela, C. Hetz, M. A. Carrasco, S. T. Ferreira and C. Hidalgo. (2011). Amyloid β peptide oligomers stimulate RyR-mediated Ca2+release inducing mitochondrial fragmentation and prevent RyR-mediated dendritic spine remodeling produced by BDNF in hippocampal neurons. Antiox Red Sig. 14:1209-23.

 Andres Klein, Matías Mosqueira, Gabriela Martinez, Fermín Robledo, Marcela González, Benjamín Caballero, Gonzalo I. Cancino, Alejandra R. Alvarez, Claudio Hetz and  Silvana Zanlungo. (2011)Lack of activation of the Unfolded Protein Response (UPR) in mouse and cellular models of Niemann-Pick type C disease. Neurodeg Dis. 8(3):124-8

 Sanjeev Gupta, Ayswaria Deepti, Shane Deegan, Fernanda Lisbona, Claudio Hetz and Afshin Samali. (2010). HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1-XBP1 Signalling through a physical interaction. Plos Biology. 8: e1000410-e1000410.

 Melissa Nassif, Soledad Matus, Karen Castillo, and Claudio Hetz (2010) Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway. Antiox Red. Sig, 13:1955-89.

 Matus S., Nassif M., Glimcher LH, and HetzC. (2009). XBP-1 deficiency in the nervous system revealed a homeostatic switch to activate autophagy. Autophagy. Nov 6;5(8). (Cover illustration) *#

 Hetz C. and Glimcher L. (2009). Fine tuning of the Unfolded Protein Response: Assembling the IRE1 interactome. Mol Cell. 35:551-61. *#

 Hetz C, Thielen P, Matus S., M Nassif, Court F., Cuervo AM., Martinez G., Kiffin R., R.H. Brown and Glimcher L. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.  Genes & Dev. 23:2294–2306. (Cover illustration) *# Commented in Genes Dev. (2009), 23:2294-306.

 Lisbona F. and Hetz C. (2009). Turning off the unfolded protein response: An interplay between the apoptosis machinery and ER stress signaling. Cell Cycle. 8:3-4.*#

 Lisbona F., Rojas D., Thielen P., Zamorano S., Todd D., Martinon F., Glavic A., Kress C.,, Lin J., Walter P., Reed J., Glimcher L. and Hetz C. (2009). BAX Inhibitor-1 is a negative regulator of the ER stress sensor IRE1. Mol. Cell. 33:679-691.*# (Cover illustration). Commented in Mol Cell (2009), 33:669-70.

 Hetz C. (2009). The UPR as a survival factor of cancer cells: More than folding proteins? Leukemia Res. 33:880-882.*#

 Matus S., Lisbona F., Torres M., Leon C., Thielen P., and Hetz C. (2008). The stress rheostat: Interplay between the Unfolded Protein Response (UPR) and Autophagy in neurodegeneration. Curr. Mol. Med. 8:157-172. *#.

 Hetz C. (2008). Apoptosis, Autophagy and Necrosis: From mechanisms to biomedical applications. Curr. Mol. Med. 8(2):76-77 *#. Editorial comment.

 Hetz C, Lee AH, Gonzalez-Romero D., Thielen P., Castilla J., Soto C. and Glimcher L. (2008). The   Unfolded Protein Response transcription factor XBP-1 does not influence Prion replication or pathogenesis. Proc. Natl. Acad Sci.  105: 757-62 *#

 Hetz C. and Glimcher L. (2008) The deadly job of night Killer: New regulatory roles of the BCL-2 family in organelle physiology. Trends in Cell Biol.  18: 38-44 *#. (Cover illustration)

 Hetz C. and Glimcher L. (2008). The UPRosome and XBP-1: mastering secretory cell function.  Curr.  Immunol Rev.  4:1-10*#.

 Steele A., Hetz C., Yi C., Jackson W., Borkowski A., Yuan J., Wollmann R., and Lindquist S. (2007). Prion pathogenesis is independent of Caspase-12. Prion.  4:1-5. *#

 Steele A., King O., Jackson W., Hetz C., Borkowski A., Thielen P., Wollmann R., and Lindquist S. (2007). Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo (2007) J. of Neuroscience. 27: 13022-7. *

 Hetz C. (2007). ER stress signaling: Form adaptation to irreversible cellular damage. Antiox Redox Signal. 9:1-12. *#

 Hetz C. Thielen P., Fisher J., Pacinelli, P., Brown, R., Korsmeyer S. and Glimcher L. (2007). The Pro-apoptotic BCL-2 Family Member BIM Mediates Motoneuron Loss in a Model of Amyotrophic Lateral Sclerosis. Cell Death and Diff. 14(7):1386-1389.*#

 Hetz, C., Castilla, J. and Soto C. (2007). Perturbation of endoplasmic reticulum homeostasis facilitates prion replication. J. Biol. Chem. 282:12725-33. *#

 Hetz, C, Bernasconi, P., Fisher, J., Lee, A., Bassik, M., Antonsson, B., Brandt, G., Iwakoshi, N,. Schinzel, A., Glimcher, L. and Korsmeyer, S.  (2006). Proapoptotic BAX and BAK modulate the unfolded protein response by a direct  interaction with IRE1alpha. Science.312: 572-6. #. Commented in Nat. Rev. Cell Biol. (2006) 7:388 Handling the stress; ACS Chem. Biol. (2006) 1:188. Stressed out cells.

 Hetz, C. and Soto, C. 2006. Emerging roles of the Unfolded protein response signaling in physiology and disease. Curr. Mol. Med. 6: 1-3. Editorial comment as executive editor.*#

 Hetz, C. and Soto, C. 2006. Stressing out the ER: A Role of unfolded protein response in prion-related disorders Curr. Mol. Med. 6:37-43.*#

 Hetz, C., Vitte, P., Bombrun, A., Rostovtseva, T., Montessuit, S., Hiver, A., Schwarz, M., Church, D., Korsmeyer, S., Martinou, J.C. and Antonsson, B. 2005. Bax channel inhibitors prevent cytochrome c release from mitochondria and protect neurons in a model of global brain ischemia. J. Biol. Chem. 280: 42960-42970.*

 Hetz, C., Torres, V., and Quest A. 2005. Beyond apoptosis: Non-apoptotic cell death in physiology and disease. Biochem. Cell. Biol. 83:579-588.*

 Schinzel, A., Takeuchi, O., Huang, Z., Fisher, J., Zhou, Z., Rubens J., Hetz, C. Danial, N., Moskowits, M., and Korsmeyer, S. 2005. Cyclophilin D is an essential component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc. Natl Acad. Sci. U.S.A. 102:12005-12010.

 Castilla, J., Saa, P., Hetz, C. and Soto, C. 2005. In vitro generation of infectious scrapie prions. Cell. 121:195-206.*. Commented in Cell (2005) 121:155-162. From microbes to prions: The final proof         of the prion  hypothesis; Science (2005) 421:3. Proof positive for prions; Nature    (2005) 432:39. Prion progress; Nature Med. (2005) 11:480. Nothing but prion.

 Hetz C., Russelakis, M., Wälchli S., Carboni S., Vial-Knecht E., Maundrell K. and Soto, C. 2005. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J. Neurosci. 25:2793-2802.*

 Russelakis, M., Hetz C., Maundrell K., and Soto, C. 2004. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts.  Am. J. Pathol. 165:1839-1848.*

 Castilla C., Hetz C., Soto C. 2004. Molecular mechanisms of neurotoxicity of pathological Prion protein. Curr. Mol. Med. 4:397-403. *

 Hetz C., Russelakis, M., Maundrell, K. Castilla, J. and Soto, C. 2003. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 22:5435-5445. *. Commented in Science, STKE (2003) 302:1007. Prions stress out the ER.

 Hetz, C., Maundrell, K. and Soto, C. 2003. Is loss of function of the prion protein the cause of Prion Disorders? Trends Mol. Med.  9:237-243.*

 Hetz, C. and Soto, C. 2003. Prion Misfolding and Disease: The Case of Prion Protein. Cell. Mol. Life Sci. 60:133-1432.*

 Hetz C., Benavent, S. Bieler, S. and Soto, C. 2003. Prion Protein Misfolding and Brain Degeneration. Curr. Med. Chem. 3:137-147.*

 Hetz, C., Hunn, M., Rojas, P. Leyton, L., and Quest, A. F. 2002. Caspase-dependent Initiation of Apoptosis and Necrosis by the Fas Recetor: A Role for the Lipid Second Messenger Ceramide in Initiation of FasL-induced Necrosis.  J. Cell Sci. 115: 4671-83.*. Commented in J. Cell. Sci. (2002) 115:e2304. Apoptosis vs necrosis: ceramide decides it. and in Science, STKE (2002), Issue 158: 414. A Back-up death plan.

 Hetz, C. Bono, M., Barros, F.and Lagos, R.. 2002. Microcin E492, a Channel-forming Bacteriocin from Klebsiella pneumoniae, Induces Apoptosis in Some Human Cell Lines. Proc. Natl. Acad. Sci USA. 99:2696-2701. *

 Leyton, L., Schneider, P., Labra, C., Ruegg, C., Hetz, C., Quest, A. and Brown C. 2001. Thy-1 binds to the integrin b3 on astrocytes and triggers formation of focal contact sites. Curr. Biol. 11:1028-38.*

 Barros, F., Stutzin, A., Calixto, A., Catalán, M., Castro, J., Hetz, C., and Hermosilla, T. 2001. Non-selective Cation Channels as Effectors of Free Radical-induced Liver Cell Necrosis.  Hepatology. 33:114-22.*

 Lagos, R., Baeza, M., Corsini, G., Hetz, C., Strahsburger, E., Castillo J., Vergara C., and Monasterio O. 2001. Structure, Organization and Characterization of the Gene Cluster Involved in the Production of Microcin E492, a Channel-Forming Bacteriocin. Mol. Microbiol. 42: 229-244.*

 Book chapters

Galleguillos D., Matus S. Valenzuela V., Valdes P.,  MArtinez A.,  Nassif M., Torres M., Martinez G., and  Hetz C. 2009.  Targeting endoplasmic reticulum stress pathways to alleviate neurological disorders associated with protein misfolding. E-book series. Bentham Science Publishers.

 Rojas D., Caballero, B., Zamorano S., Lisbona F., and Hetz C. 2010. Alternative Functions of the BCL-2

Protein Family at the Endoplasmic Reticulum. Bioscience publishers.  Adv Exp Med Biol. 2010;687:33-47.

 Hetz C. BCL-2 protein family. 2010. Essential regulators of cell death. Preface.  Bioscience publishers.  Adv Exp Med Biol. 2010;687:vii-viii.

Matus S., Thielen P., Nassif M., Torres M., and Hetz C (2008) Targeting stress pathways to treat neurological disorders linked to protein misfolding. Protein Misfolding. Nova Science Publishers, Inc. Editor Cian B. O’Doherty and Adam C. Byrne  *#

Russelakis-Carneiro, M., Hetz, C., Castilla, J. and Soto, C. (2004) Neurodegeneration induced by prion protein misfolding. In “Neuroprotection: Models, Mechanisms, Therapies” M. Bahr (Ed.). Wiley-VCH.*

 Morales R., Hetz C. and Soto C. (2004). Signaling Pathways Controlling Prion Neurotoxicity: Role of Endoplasmic reticulum stress-mediated Apoptosis. Neurodegeneration in Prion Disorders.  Klewer. Editor: David Brown. *

 Books

Book editor: e-book “Protein Misfolding Disorders: A Trip into the ER”. 2009. Bentham Science Publishers. In  press http://www.bentham.org/ebooks/9781608050130/index.htm  

 Book editor: “BCL2 Protein Family: Functions beyond Apoptosis”. 2010. Bioscience publishers.  In press http://www.landesbioscience.com/books/iu/id/3413/