Donna Spiegelman

optitxs

Program, documents and manuscripts for sample size and power calculation for longitudinal studies written by Xavier Basagaña and Donna Spiegelman

Calculating the minimum number of participants (N) for a fixed number of measurements (r), given pre-specified power; the minimum number of repeated measurements (r) for fixed N, power, and pre-specified study length or time between visits; power for a given (N,r); and the optimal (N,r) subject to power or cost constraints. Compound symmetry, damped exponential, and random slopes covariances are supported.

optitxs.r  Version 1.1

optitxs User Manual 

Manuscripts:

The Design of Observational Longitudinal Studies        APPENDIX

Power & sample size calculations for Longitudinal Studies Estimating a Main Effect of a Time-Varying Exposure         APPENDIX

Power & sample size calculations for Longitudinal Studies Comparing Rates of Change with a Time-Varying Exposure         APPENDIX