Selected Publications
Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J. and Cantley, L.C. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Molecular Cell 10, 151-162.6.
Tee, A.R., Fingar D.C., Manning, B.D., Kwiatkowski, D.J., Cantley L.C., and Blenis, J. (2002) Tuberous sclerosis complex-1 and –2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. PNAS 99, 13571-13576.
Manning, B.D. and Cantley, L.C. (2002) Hitting the target: emerging technologies in the search for kinase substrates. Science STKE pe49.
Tee, A.R., Manning, B.D., Roux, P.P., Cantley, L.C., and Blenis, J. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex towards Rheb. Current Biology 13, 1259-1268.
Luo, J., Manning, B.D., and Cantley, L.C. (2003) Targeting the PI3K-Akt pathway in human cancers: rationale and promise. Cancer Cell 4, 257-262.
Manning, B.D. and Cantley, L.C. (2003) Rheb fills a GAP between TSC and TOR. Trends in Biochemical Sciences 28, 573-576.
Shaw, R.J., Bardeesy, N., Manning, B.D., Lopez, L., Kosmatka, M., DePinho, R.A., and Cantley, L.C. (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6, 91-99.
Brugarolas, J., Lei, K., Hurley, R.L., Manning, B.D., Reiling, J.H., Hafen, E., Witters, L.A., Ellisen, L.W., and Kaelin, W.G. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes & Development 18, 2893-2904.
Manning, B.D. (2004) Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis. Journal of Cell Biology 167, 399-403.
Manning, B.D., Logsdon, M.N., Lipovsky, A.I., Abbott, D., Kwiatkowski, D.J., and Cantley, L.C. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking TSC2. Genes & Development 19, 1773-1778.
Sodhi, A., Chaisuparat, R., Hu, J., Ramsdell, A.K., Manning, B.D., Sausville, E.A., Sawai, E.T., Molinolo, A., Gutkind, J.S. and Montaner, S. (2006) The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi’s Sarcoma Associated Herpesvirus G Protein-Coupled Receptor. Cancer Cell 10, 133-143.
Zhang, H.H., Lipovsky, A.I., Dibble, C.C., Sahin, M., and Manning, B.D. (2006) S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Molecular Cell 24, 185-197.
Manning, B.D. and Cantley, L.C. (2007) AKT/PKB signaling: Navigating downstream. Cell 129, 1261-1274.
Ozcan, U., Ozcan, L., Yilmaz, E., Duvel, K., Sahin, M., Manning, B.D., and Hotamisligil, G.S. (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell 29, 541-551.
Huang, J. and Manning B.D. (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochemical Journal 412, 179-90.
Huang, J., Dibble, C.C., Matsuzaki, M., and Manning, B.D. (2008) The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Molecular and Cellular Biology 28, 4104-4115.
Manning, B.D. (2009) Challenges and opportunities in defining the essential cancer kinome. Science Signaling 2:pe15.
Zhang, H.H., Huang, J., Duvel, K., Boback, B., Wu, S., Squillace, R.M., Wu, C.L., and Manning, B.D. (2009) Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 4:e6189.
Huang, J., Wu, S., Wu, C.L., and Manning, B.D. (2009) Signaling events downstream of mTOR complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Research 69:6107-14.
Dibble, C.C., Asara, J., and Manning, B.D. (2009) Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Molecular and Cellular Biology 29: In Press.
Dibble, C.C. and Manning, B.D. (2009) A molecular link between Akt regulation and chemotherapeutic response. Cancer Cell 16: In Press.