For more than 20 years, Dr. Seage has conducted studies of the behavioral and biological aspects of HIV transmission and natural history. His previous research has focused on understanding the biology of HIV transmission, the behavioral epidemiology of HIV transmission, both among men who have sex with men and women, the development and acceptability of prevention interventions, ranging from HIV vaccines, mircobicides and behaviors, and the cost and cost-effectiveness of treating HIV infection. His research also has included prospective cohort studies of men who have sex with men, the Boston Partners Study, and the Boston Young Men's Study.

Dr. Seage led a three-site study of microbicide usage, acceptability, and HIV-related risk behaviors among 743 drug-involved women in Providence, RI, Bridgeport, CT, and San Juan, Puerto Rico. He has been the principal investigator and protocol chair for a series of domestic HIVNET (HIV network of prevention trials) studies, including the Vaccine Preparedness Study (VPS-1), a prospective cohort study among 4,892 individuals at risk for HIV infection, and VPS-2, a prospective cohort study which enrolled an additional 2,316 individuals at risk, including 1,647 women. Dr. Seage was co-PI on the Harvard HIV Vaccine Trial Site in Botswana, and is currently principal investigator of a case-crossover study designed to determine the role of alcohol use and unsafe sex among individuals at risk for HIV-1 infection. He is also co-investigator on projects evaluating the cost-effectiveness of HIV screening on treatment and prevention, and of preventing HIV complications in the era of highly effective antiretroviral therapies (ART).

Most recently, Dr. Seage has been involved in studies of pediatric HIV infection, evaluating the impact of ART on a variety of outcomes among perinatally infected children, including their long term survival. Dr Seage was recently awarded a $50 million, 5-year grant for the Pediatric and HIV/AIDS Cohort Study (PHACS) Data and Operations Center, to study the long-term effects on children of antiretroviral (ART) drugs that were administered to their pregnant mothers. This project also studies the effects of perinatally-acquired HIV infection on growth and development of adolescents.

ScD, MPH, Boston University