Publications
Uysal KT, Wiesbrock SM, Marino MW, and Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF function. Nature 1998, 389:610-614.
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, and Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 2000, 290:134-138.
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker R, Suttles J, Fazio S, Hotamisligil, GS, Linton, Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine 2001, 7:699-705.
Hirosumi J, Tuncman G, Chang, L, Gorgun CZ, Uysal KT, Maeda, K, Karin, and Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-61.
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil, GS. Protection against obesity in mice lacking adipocyte fatty acid binding proteins. Cell Metabolism 2005, 1:107-119.
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313(5790):1137-40.
Wellen K, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS.?Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 2007, 129:537-548.
Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding-protein aP2. Nature 2007, 447(7147):959-65.
Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell 2008, 29:541-551.