Publications
Azzam, E.I., S.M. de Toledo, and J.B. Little. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from a-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98: 473-478, 2001.
Nagasawa, H., A. Cremesti, R. Kolesnick, Z. Fuks, and J.B. Little. Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res. 62: 2531-2534, 2002.
Azzam, E.I., S.M. de Toledo, D.R. Spitz and J.B. Little. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62:5436-5443, 2002.
Little, J.B., H. Nagasawa, G.C. Li and D.J. Chen. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159:262-267, 2003.
Azzam, E.I., S.M. de Toledo, and J.B. Little. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res. 63:7128-7135, 2004.
Nagasawa, H., Y. Peng, Y.-C. Lio, C.J. Chen, J. Bedford, and J.B. Little. Role of homologous recombination in the alpha particle bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiat. Res. 164:141-147, 2005.
Chuang, E.Y., X. Chen, M-H. Tsai, H. Yan, C-Y. Li, J.B. Mitchell, H. Nagasawa, P.F. Wilson, Y. Peng, M.M. Fitzek, J.S. Bedford and J.B. Little. Abnormal gene expression profiles in unaffected parents of patients with hereditary type retinoblastoma. Cancer Res. 66:3428-3433, 2006.
Kato, T.A., H. Nagasawa, M.M. Weil, P.C. Genik, J.B. Little and J.S. Bedford. Gamma-H2AX foci after low dose-rate irradiation reveal mouse Atm haploinsufficiency. Radiat. Res. (in press, 2006).
Little, J.B. Non-targeted effects of radiation: Implications for low dose exposures. Health Physics (in press, 2006).