TITLE: Assessing the impact of parents' genes on their children's disease risk

ABSTRACT: Parents' genes may contribute directly to their children's disease risk, 
for example, during pregnancy or spermatogenesis. The standard Transmission 
Disequilibrium Test (TDT)--often preferred because it is immune to confounding 
due to population stratification--uses parental data but cannot detect any direct 
parental-genotype effects. Recent extensions of the TDT framework can detect direct 
parental effects, parent-child genotype interactions, etc. I review these methods; 
present power calculations comparing case-parent trio designs to case-population 
control designs; and present recent applications.

Peter Kraft, 22 October 2002.