Lu Qi

Dr. Qi's major research interests include:

1. Genetic/nutrition Epidemiology of type 2 diabetes, cardiovascular complications, and obesity
2. Gene-environment interactions in relation to obesity, type 2 diabetes and cardiovascular disease
3. Lifestyle/diet intervention in prevention of obesity and metabolic disorders
4. Application of metabolomics and epigenetics in epidemiology research

Dr. Qi's research has focused on the genetic, nutrition, biochemical risk factors and gene-environment interactions in relation to obesity, type 2 diabetes and the cardiovascular complications in diabetic patients. Dr. Qi is the Principal Investigator of NIH R01 grant 'Obesity Genes, Energy Regulation in Response to Weight-Loss Diets' (NIDDK), a study in large cohorts (the NHS and HPFS) and randomized intervention trials (the Pounds Lost trial and DIRECT trial); he is the Principal Investigator of NIH R01 grant on the genome-wide association study of coronary heart disease among diabetic patients in the NHS and HPFS (NHLBI); he is the Principal Investigator of the American Heart Association Scientist Development Grant on the biochemical and genetic predictors for cardiovascular disease in diabetes; he is also the Co-Principal Investigator of European Foundation for the Study of Diabetes (EFSD) funded lifestyle intervention trial on prevention of metabolic risk in women with history of gestational diabetes (GDM).

Dr. Qi serves as Editor-in-Chief for World Journal of Diabetes, Associate Editor for BMC Medical Genetics, and editorial board member for the Journal of Nutrition, the International Journal of Molecular Epidemiology and Genetics, and Frontiers in Nutrigenomics. Dr. Qi is a fellow of American Heart Association (FAHA) and American College of Nutrition (FACN).

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Recruitment of a research fellow (posted on 5/14/2012)

Candidates should have a doctoral degree in epidemiology, nutrition, or genetics, with research experience in epidemiology. Interest/experience in gene-environment interactions, and obesity, cardiovascular disease and diabetes a plus. The position will include the design and analysis of genome-wide association with obesity, and gene-environment interactions in large prospective cohorts and randomized diet intervention trials. There are many opportunities for interdisciplinary, collaborative research through Harvard School of Public Health. This is a 1-2 year position under the supervision of Dr. Lu Qi (nhlqi@channing.harvard.edu, luqi@hsph.harvard.edu)

2008  Roger R. Williams Award for Genetic Epidemiology; American Heart Association

2009  Mark Bieber Award; American Heart Association

2010  Jeremiah and Rose Stamler Research Award for New Investigator (finalist); American Heart Association

2010  Michaela Modan Memorial Award; American Diabetes Association

2012  Sandra Daugherty Award for Excellence in Cardiovascular Disease or  Hypertension Epidemiology (finalist); American Heart Association

Qi L, Parast L, Cai T, Powers C, Gervino E, Hauser T, Hu F, Doria A. Genetic Susceptibility to Coronary Heart Disease in Type 2 Diabetes: Three Independent Studies. J Am Coll Cardiol. 2011 Dec 13;58(25):2675-82.

Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in hispanics. Circulation. 2011 Feb 1;123(4):374-80.

Wen W. … Qi L. (co-first author), … Meta-analysis identifies common variants associated with body mass index in East Asians. Nat. Genet. 2012 (in press)

Qi Q, Bray G, Smith S, Hu F, Sacks F, Qi L. Insulin receptor substrate 1 (IRS1) gene variation modifies insulin resistance response to weight-loss diets in a two-year randomized trial. Circulation. 2011 Aug 2;124(5):563-71

Kilpelainen T, Qi L*, (co-corresponding author) … Loos R. Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Med. 2011 Nov;8(11):e1001116.

Qi L, Menzaghi C, Salvemini L, Bonis C, Trischitta V and Hu F. A novel locus FER is associated with serum HMW adiponectin levels. Diabetes 2011 (in press)

Qi L, Cornelis M, Kraft P, Stanya K., Kao W, Pankow J, Dupuis J, Florez J, Fox C, Paré G, Sun Q, Girman C, Laurie C, Mirel D, Manolio T, Chasman D, Boerwinkle E, Ridker P, Hunter D, Meigs J, Lee C, van Dam R, and Hu F. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 2010 Feb 10.

Heid* I, Jackson A*, Randall J*, Winkler T*, Qi L*, Steinthorsdottir T*, et al. Meta-analysis identifies 13 novel loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 (Co-first author) 

He M, van Dam R, Rimm E., Hu F., Qi L. Whole grain, cereal fiber, bran, and germ intake and the risks of all-cause and CVD-specific mortality among women with type 2 diabetes. Circulation, 2010 25;121(20):2162-8

Qi L, Cornelis M, Kraft P, Jensen M, van Dam R, Sun Q, Girman C, Laurie C, Mirel D, Hunter D, Rimm E, Hu F. Genetic variants in ABO blood group region, plasma soluble E-selectin levels, and risk of type 2 diabetes. Hum Mol Genet. 2010 19(9):1856-62

Lango Allen H, Estrada K, Lettre G, … Qi L… Hirschhorn JN. Hundreds of variant clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14;467(7317):832-8.

Speliotes EK, Willer CJ, Berndt SI,… Qi L… Loos RJ. Assoication analysis of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Nov;42(11):937-48.

Qi L, Rifai N, Hu F. Interleukin 6 receptor gene, plasma CRP, and diabetes risk in women. Diabetes. 2009 58(1):275-8.

Qi L, Cornelis M, Zhang C, Van Dam R, Hu F. Genetic Predisposition, Western Dietary Pattern, and the Risk of Type 2 Diabetes in Men. Am J Clin Nutr. 2009 89(5):1453-8. 

Qi L, Kang K, Lee C, van Dam R, Zhang C, Kraft P, Hunter D, and Hu F. Fat mass-and obesity-associated (FTO) Gene Variant Is Associated with Obesity: Longitudinal Analyses of Two Cohort Studies and Functional Test. Diabetes. 2008 57(11):3145-51.

Qi L, Kraft P, David H, Hu F. The Common Obesity Variant near MC4R Gene Is Associated with Higher Intakes of Total Energy and Dietary Fat, Weight Change, and Diabetes Risk in Women. Hum Mol Genet. 2008 15;17(22):3502-8.

Loos R, …Qi L, …Wareham N, Barroso I. Association studies involving over 90,000 samples demonstrate that common variants near to MC4R influence fat mass, weight and risk of obesity. Nat Genet. 2008;40(6):768-75.

Zeggini E, …Qi L.. DIAGRAM Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies several additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40(5):638-45

Qi L, Doria A, Giorgi E, and Hu F. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in US women: A tagging-SNP haplotype analysis. Diabetes. 2007;56(6):1586-91.

Qi L, Zhang C, van Dam R, and Hu F. Interleukin-6 gene and adiposity: associations in two independent cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab., 2007; 92(9):3618-25

Qi L, Rifai N, and Hu F. Interleukin 6 receptor gene variations, plasma interleukin 6 levels, and type 2 diabetes in US women. Diabetes, 2007; 56(12):3075-81

Qi L, Manson J, Meigs J, Doria A, Hunter D, Mantzoros C, and Hu F. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes, 2006, 55(5):1512-6

Qi L, van Dam R, Meigs J, Manson J, Hunter D, and Hu F. IL-6 genetic variability and type 2 diabetes: Large-scale case-control study and meta-analysis. Hum Mol Genet. 2006; 15(11):1914-20.

Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, Doria A, and Hu F. The +276 polymorphism of the APM1 gene and plasma adiponectin concentration and cardiovascular risk in diabetic men. Diabetes. 2005; 54(5):1607-10.

Qi L, Meigs J, Manson J, Ma J, Hunter D, Rifai N, and Hu F. HFE genetic variability, dietary iron intake, body iron stores and the risk of type 2 diabetes in US women. Diabetes. 2005; 54(12):3567-72.