William Mair

wmair [at] hsph.harvard.edu

Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.

In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.

Postdoctoral positions are available for enthusiastic and driven scientists wishing to study the molecular and genetic mechanisms underlying the aging process, with the goal of utilizing this knowledge to develop novel therapies for age-related pathologies. The lab uses a combination of genetic, molecular and biochemical approaches to study aging in both mammalian cells and C. elegans. Candidates should be highly motivated and have relevant training in molecular biology and biochemical techniques. Prior C. elegans experience is not required. Candidates with a Ph.D and a strong research history as indicated by their publication record are encouraged to apply.

Please email a letter of interest including your research history, CV and future research interests to William Mair. Applicants should outline specifically why they are excited by our research program and what they feel they can contribute our to ongoing efforts. Please note that although funding support is not a prerequisite, all postdocs are expected to apply for individual research fellowships. 

Select candidates will be asked to arrange for three letters of references to be submitted independently.

William Mair, Ph.D.

Assistant Professor of Genetics & Complex Diseases

wmair [at] hsph.harvard.edu