XWXW implements the Unified Haseman-Elston method for non-parametric linkage test with quantitative traits.
It optimally utilizes the information from a sib-pair. It is uniformly more powerful than both the classical
H-E method and the revistited H-E method. Program GENIBD from SAGE
is required for sib-pair ibd estimation.
XWXW is available for the following platforms:
Xu X, Palmer LJ, Horvath S, and Wei LJ. Combining Multiple Phenotypic Traits
Optimally for Detecting Linkage with Sib-pair Observations. (2001) Genet. Epidemiol. 2001;21 Suppl 1:S479-83.
Xu X, Weiss S, Xu X, Wei LJ. A unified Haseman-Elston
regression method for testing linkage with quantitative trait. Am. J.
Hum. Genet. 2000 Oct;67(4):1025-8. Epub 2000 Aug 28.