XWXW implements the Unified Haseman-Elston method for non-parametric linkage test with quantitative traits. It optimally utilizes the information from a sib-pair. It is uniformly more powerful than both the classical H-E method and the revistited H-E method. Program GENIBD from SAGE or GeneHunter2 is required for sib-pair ibd estimation.

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XWXW is available for the following platforms:


Xu X, Palmer LJ, Horvath S, and Wei LJ. Combining Multiple Phenotypic Traits Optimally for Detecting Linkage with Sib-pair Observations. (2001) Genet. Epidemiol. 2001;21 Suppl 1:S479-83.

Xu X, Weiss S, Xu X, Wei LJ. A unified Haseman-Elston regression method for testing linkage with quantitative trait. Am. J. Hum. Genet. 2000 Oct;67(4):1025-8. Epub 2000 Aug 28.