Our laboratory’s interest is in mucosal immunology and the gut microbiota. Our studies address key questions relevant to the pathophysiology of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). We study intestinal inflammation in colitis and the tumor microenviroment in CRC, with a specific focus on the gut microbiota and immune system. We employ both specified pathogen free and gnotobiotic mouse systems for the in vivo study of host-microbial symbiont interactions in the gut. We utilize approaches spanning the disciplines of cell biology, microbiology, cancer biology, immunology, and computational biology to mechanistically interrogate the regulation of gut homeostasis, inflammation and tumorigenesis. By unraveling the functional interactions between host immunity and the microbiota, we hope to gain new perspective on IBD and CRC.