Inflammation is a key contributor to carcinogenesis, and there is an increased incidence of cancer in patients with chronic inflammatory diseases. Ulcerative colitis is one of the three highest risk factors for the development of colorectal cancer. Recent data suggest that immune responses to the commensal microbiota may influence the development of colorectal cancer. Both host immunity and intestinal microbial communities regulate inflammatory responses in the gut.
Our laboratory aims to expand the understanding of inflammation in colon cancer by studying intestinal microbial communities, monocyte subsets, and their interactions in the tumor microenvironment. By unraveling the functional interactions between host immunity and the microbiota, we hope to gain new perspective on how tumors evolve.