Mihee Kim
Yuan Laboratory
Harvard School of Public Health
p53
is a tumor suppressor gene that is lost or mutated in almost 50% of human
cancers. In response to a wide variety of stress signals, p53 regulates
processes such as the cell cycle arrest, cell death and DNA repair. To better
understand p53, we study p300/CBP, transcriptional coactivators of p53.
p300/CBP also play key roles in the stabilization and the degradation of
p53. Data has demonstrated that p300 can interact with both p53 and p53's
negative regulator, Mdm2. We believe that p300/CBP, p53 and MDM2 serve as
major integrators of signals generated by genotoxic stress and that their
coordination is important for optimal response and decrease the likelihood
of cancer. My research is focused on trying to understand the mechanism
of this interaction.
| Ph.D. Program |
Biological Sciences in Public Health (BPH)
|
| Previous Education |
Harvard School of Public Health (Boston, MA), S.M. Environmental
Health
Columbia University (New York, NY), A.B. in Biological Sciences
|
| Country of Origin: |
USA |
| Email |
mmkim@hsph.harvard.edu |
| External Links |
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