Ahmed Alkhateeb

Research FellowAlkhateeb_2014

Department of Genetics & Complex Diseases
655 Huntington Avenue
Building 2, Room 133
Boston, MA 02115
khateeb[at]hsph.harvard.edu

Education:

  • Ph.D., Cell and Molecular Biology, Pennsylvania State University College of Medicine, 2013
  • B.S., Biology, Susquehanna University, 2007

Research Summary:

My research revolves around two major themes:

  1. Defining the role of iron in innate immunity and inflammation: I am particularly interested in how iron regulates the function of microglia – the resident immune cells in the brain. I am utilizing molecular and pharmacological approaches to examine the role of microglia in neurodegenerative diseases and CNS inflammation.
  2. Exploring the regulation of iron absorption and mobilization: I am primarily interested in the signaling components that regulate the expression of the master iron regulator hepcidin. High levels of hepcidin cause anemia while low levels cause iron overload disease, therefore understanding its regulation will allow for the development of pharmacological strategies to modulate its expression.

Publications:

Alkhateeb A, Zubritsky L, Kinsman B, Leitzel K, Ali SM, Campbell-Baird C, Connor J, Lipton A. (2014) Elevation in multiple inflammatory biomarkers predicts survival of pancreatic cancer patients with inoperable disease. Journal of Gastrointestinal Cancer. Published online.

 Alkhateeb A and Connor J. (2013) The Significance of Ferritin in Cancer: Anti-oxidation, Inflammation and Tumorigenesis. Biochemica Biophysica Acta – Reviews on Cancer. 1836 (2) 245–254.

Alkhateeb A, Han B, Connor J. (2013) Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages. Breast Cancer Research and Treatment. 137 (3) 733-744.

Alkhateeb A, Leitzel K, Ali SM, Campbell-Baird C, Evans M, Fuchs E, Köstler WJ, Lipton A, Connor J. (2012) Elevation in serum inflammatory biomarkers predicts response to trastuzumab-containing therapy. PLoS ONE. 5 (10) e13636.

Alkhateeb A and Connor J. (2010) Nuclear Ferritin: A new role for ferritin in cell biology. Biochemica Biophysica Acta. 1800 (8) 793-797. (Review)