Portrait

Georgios Sotiriou

Research Fellow

Department of Environmental Health

Center for Nanotechnology & Nanotoxicology

email: sotiriou@hsph.harvard.edu

 

Research interests

  • Interactions of nanoparticles with biological systems

Nanoparticles are employed everyday in commodities and advanced sophisticated applications. Here, we study their interactions with biological systems in-vitro and in-vivo in order to obtain a fundamental understanding of their effect. Based on this understanding we design safer nanostructured materials that possess all desired properties but do not pose risks to the environment and human health.

  • Nanoparticles in theranostics

ACS Nano vol. 6, pp. 3888-3897 (2012).

ACS Nano vol. 6, pp. 3888-3897 (2012).

Nanoparticles that emit light light upon excitation (e.g. nanophosphors, quantum dots) and plasmonic nanoparticles (e.g. Au, Ag) can be used as “nanotools” in bioapplications.  Here, we synthesize such nanoparticles and investigate the parameters that influence their properties, targeting superior performance in diagnostics and therapeutic applications.

 

  • Advanced multifunctional nanocomposites

Polymer matrixes play important roles in many areas, however, more often than not, they need nanoparticles as fillers for superior performance, and thus nanocomposites are made. We synthesize such filler nanoparticles for high-tech biomedical applications and investigate their dispersion in selected polymers and their life-cycle implications.

Links

Selected Publications

From a total of 27 publications, for full list please click the Publications link

 

1.   G.A. Sotiriou, F. Starsich, A. Dasargyri, M.C. Wurnig, F. Krumeich, A. Boss, J-C. Leroux, S.E. Pratsinis. “Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-coated Au/Fe2O3 Nanoaggregates”, Adv. Funct. Mater. 24, 2818-2827 (2014). link

Sotiriou_AdvFunctMater_2014_frontispiece small

  • Frontispiece of issue published on 21 May 2014: link
  • Featured in ETH Newslink
  • Featured in IEEE Spectrum: link
  • Featured in InterPharma.ch (in German): link
  • Featured in MedGadget: link
  • Featured in NANOTECH ETC: link
  • Featured in inPharma-Technologist: link
  • Featured in Medizin & Technik (in German): link

2.   G.A. Sotiriou, C. Watson, K.M. Murdaugh, T.H. Darrah, G. Pyrgiotakis, A. Elder, J.D. Brain, P. Demokritou. “Engineering Safer-by-Design, Transparent, Silica-coated ZnO Nanorods with Reduced DNA Damage Potential”, Environ. Sci.: Nano 1, 144-153 (2014). link

Safer ZnO

  • Featured in RSC Chemistry Worldlink
  • Featured in Harvard Gazettelink
  • Featured in HSPH News: link
  • Featured in ASPPH Friday Letters: link
  • Featured in Süddeutsche.de (in German): link

3.   A. Pratsinis, P. Hervella, J-C. Leroux, S.E. Pratsinis, G.A. Sotiriou, “Toxicity of Silver Nanoparticles in Macrophages”, Small 9, 2576-2584 (2013). link

4.   G.A. Sotiriou, C.O. Blattmann, S.E. Pratsinis, “Flexible, Multifunctional, Magnetically Actuated Nanocomposite Films”, Adv. Funct. Mater. 23, 34-41 (2013). link

5.   G.A. Sotiriou, E. Diaz, M. S. Long, J. Godleski, J. Brain, S.E. Pratsinis, P. Demokritou, “A Novel Platform for Pulmonary and Cardiovascular Toxicological Characterization of Inhaled Engineered Nanomaterials”, Nanotoxicology 6, 680-690 (2012). link

6.   G.A. Sotiriou, D. Franco, D. Poulikakos, A. Ferrari, “Optically Stable Biocompatible Flame-Made SiO2-Coated Y2O3:Tb3+ Nanophosphors for Cell Imaging”, ACS Nano 6, 3888–3897 (2012). link

7.   G.A. Sotiriou, A. Hirt, P.-Y. Lozach, A. Teleki, F. Krumeich, S.E. Pratsinis, “Hybrid Silica-coated, Janus-like Plasmonic-Magnetic Nanoparticles”, Chem. Mater. 23, 1985-1992 (2011). link

Chem. Mater. vol. 23, pp. 1985-1992 (2011).

 

Featured in ETH lifelink

 

8.   G.A. Sotiriou, T. Sannomiya, A. Teleki, F. Krumeich, J. Vörös, S.E. Pratsinis, “Non-toxic, Dry-coated Nanosilver for Plasmonic Biosensors”, Adv. Funct. Mater. 20, 4250-4257 (2010). link

Adv. Funct. Mater. vol. 20, pp. 4250-4257 (2010).

 

Frontispiece of issue published on 21 Dec 2010link

 

 

9.   G.A. Sotiriou, S.E. Pratsinis, “Antibacterial Activity of Nanosilver Ions and Particles”, Environ. Sci. Technol. 44, 5649-5654 (2010). link