Summary of Research

The major interest of our group is to study the regulatory pathways which control energy metabolism and metabolic homeostasis. The overarching theme of laboratory is related to interactions between metabolic and immune response, a rapidly growing field now recognized as “immunometabolism”. Our molecular, biochemical, genetic, and physiological studies focus on signaling networks and adaptive pathways integrated with nutrients, metabolism, stress, and immune responses using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways which are involved in human metabolic diseases. Our goal is to leverage this mechanistic platform to develop novel and effective preventive and therapeutic solutions for chronic metabolic diseases such as diabetes, obesity, and cardiovascular disease, which constitute the greatest threat to global human health. Our work primarily embraces three major areas of research: