Publications

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Yang L, Fu S, Calay ES, Hotamisligil GS. Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance. Cell Metabolism, 2010, 11(6):467-478. Abstract | PDF

Hotamisligil GS. Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease. Cell, 2010, 140(6):900-917. Abstract | PDF

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell, 2010, 140(3):338-348. Abstract | PDF

Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow M, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine, 2009, 12:1383-91. Abstract | PDF

Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism. Cell, 2008, 134(6):933-44. Abstract | PDF

Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest, 2008, doi:10. 1172/JCI34750. Abstract | PDF

Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis. Molecular Cell, 2008, 29:541-551. Abstract | PDF

Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, MacRae FL, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature, 2007, 447:959-965. Abstract |PDF

Wellen K, Fucho R, Gregor M, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun C, Saatcioglu F, Hotamisligil GS. Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis. Cell, 2007, 129(3):537-48. Abstract |PDF

Hotamisligil GS. Inflammation and metabolic disorders. Nature, 2006, 444(7121):860-7. Abstract | PDF

Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes. Science, 2006, 313(5790):1137-40. Abstract |PDF

Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil, GS. Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice. Diabetes, 2006, 55(7):1915-22. Abstract |PDF

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA, 2006, 103(28):10741-46. Abstract | PDF

Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA, 2006, 103(18):6970-5. Abstract| PDF

Hotamisligil, GS. Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes. Diabetes, 2005, 54:Suppl2:S73-78. Abstract | PDF

Tsai J, Tong Q, Tan G, Chang A, Orkin S, Hotamisligil, GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Reports, 2005, 6(9):879-884. Abstract | PDF

Wellen KE, Hotamisligil, GS. Inflammation, stress, and diabetes. J Clin Invest, 2005, 115:1111-1119. Abstract | PDF

Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Bio 2005, 25(2): 706-715. Abstract | PDF

Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil, GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism, 2005, 1:107-119. Abstract| PDF

Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 2005, epublication. Abstract|PDF

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science, 2004, 306:457-61. Abstract | PDF

Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation, 2004, 110(11):1492-1498. Abstract | PDF

Makowski L and Hotamisligil GS. Fatty Acid Binding Proteins—The Evolutionary Crossroads of Inflammatory and Metabolic Responses. J of Nutrition, 2004, 134(9):2464S-2468S. Abstract | PDF

Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H. Hotamisligil GS. Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology. 2004, 145(5):2214-20. Abstract | PDF

Hotamisligil GS. Inflammation, tumor necrosis factor, and insulin resistance. In Leroith, D, Taylor SI, Olefsky, JM, Eds. In Diabetes Mellitus: A Fundamental and Clinical Text. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2003, Chapter 64:953-962. PDF

Tong, Q, Sankalé, J-L, Hadigan, CM, Tan, G, Rosenberg, ES, Kanki, PJ, Grinspoon, SK, Hotamisligil, GS. Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metabol, 2003, 88:1559-1564. Abstract |PDF

Hotamisligil GS. The irresistible biology of resistin. Journal of Clinical Investigation, 2003, 111:173-174. PDF

Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance. Diabetes, 2003, 52: 300-307. Abstract | PDF

Xu, H, Uysal, KT, Becherer, D, Arner, P, Hotamisligil, GS. ALTERED TNF a Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha a in obesity. Diabetes, 2002, 51:1876-1883. Abstract | PDF

Boord, JB, Maeda, K, Makowski, L, Babaev, VR, Fazio, S, Linton, MF, Hotamisligil, GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Art, Thro, Vasc Bio, 2002, 22:1686-1691. Abstract | PDF

Hirosumi, J, Tuncman, G, Chang, L, Gorgun, CZ, Uysal, KT, Maeda, K, Karin, M, Hotamisligil, GS. A central role for JNK in obesity and insulin resistance. Nature, 2002,420:333-336. Abstract | PDF

Xu H, Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation. FEBS Lett. 506(2):97-102, 2001. Abstract | PDF

Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. Journal of Biological Chemistry. 276(28):25651-3, 2001. Abstract | PDF

Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine. 7(6):699-705, 2001. Abstract|PDF

Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 290(5489):134-138, 2000. Abstract | PDF

Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 141(9):3388-96, 2000. Abstract | PDF

Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proceedings of the National Academy of Sciences of the United States of America. 97(14):8033-8, 2000. Abstract | PDF

Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Letters. 469(1):77-82, 2000. Abstract | PDF

Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA and Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes, 1999 Oct; 48:1987-1994. Abstract | PDF

Xu H, Sethi JK, Uysal KT, Wiesbrock SM, Scheja L and Hotamisligil GS. Transmembrane Tumor Necrosis Factor (TNF)-a Inhibits Adipocyte Differentiation by Selectively Activating TNF Receptor 1. J. Biol. Chem. 1999. 274(37):26287-26295. Abstract | PDF

Samad F, Uysal KT, Wiesbrock SM, Hotamisligil GS, and Loskutoff DJ. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proceedings of The National Academy of Sciences 1999 ; 96:6902-6907. Abstract | PDF

Sethi JK and Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Seminars in Cell and Developmental Biology 1999 Apr ; 10(2):19-29. Abstract | PDF

Uysal KT, Wiesbrock SM, and Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology 1998 Dec;139(12):4832-4838. Abstract | PDF

Kirchgessner T, Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. Journal of Clinical Investigation 1997 Dec 1; 100(11): 2777-2782. Abstract | PDF

Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997 Oct 9; 389(6651): 610-614. Abstract | PDF