Publications

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Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. Aberrant islet unfolded protein response in type 2 diabetes. Sci Rep. 2014 Feb 11;4:4054. Abstract | PDF

Nakamura T, Furuhashi M, Baccaro B, Hotamisligil GS. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes, 2014. Feb;63(2):526-34. Abstract | PDF

Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice againt type 1 diabetes. Science Transl Med., 2013 Nov 13;5(211). Abstract | PDF

Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab., 2013 May 7;17(5):768-78. Abstract | PDF

Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The Role of Adipocyte XBP1 in Metabolic Regulation during Lactation. Cell Reports, 2013 May 30;3(5):1430-9. Abstract | PDF

Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genetics, 2012, 8(8):e1002902. Abstract | PDF

ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab., 2012, 16:81-9. Abstract | PDF

Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab., 2012 May 2;15(5):623-34. Abstract| PDF

Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annual Reviews Immunology, 2011. Abstract | PDF

Fu S, Yang L, Li P, Hoffman O, Dicker L, Hide W, Lin X, Watkins, SM, Ivanov A, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver ER stress in obesity. Nature, 2011, 473; 528-531. Abstract | PDF

Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in US Adults. Ann Intern Med 2010, 21;153:790-9. Abstract | PDF

Yang L, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism, 2010, 11(6):467-478. Abstract | PDF

Hotamisligil GS. Endoplasmic Reticulum stress and the inflammatory basis of metabolic disease. Cell, 2010, 140(6):900-917. Abstract | PDF

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell, 2010, 140(3):338-348. Abstract | PDF

Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow M, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine, 2009, 12:1383-91. Abstract | PDF

Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell, 2008, 134(6):933-44. Abstract | PDF

Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest, 2008, doi:10. 1172/JCI34750. Abstract | PDF

Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, MacRae FL, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature, 2007, 447:959-965. Abstract |PDF

Wellen K, Fucho R, Gregor M, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun C, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell, 2007, 129(3):537-48. Abstract |PDF

Hotamisligil GS. Inflammation and metabolic disorders. Nature, 2006, 444(7121):860-7. Abstract | PDF

Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science, 2006, 313(5790):1137-40. Abstract |PDF

Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil, GS. Regulation of metabolic responses by adipocyte/ macrophage fatty acid–binding proteins in leptin-deficient mice. Diabetes, 2006, 55(7):1915-22. Abstract |PDF

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA, 2006, 103(28):10741-46. Abstract | PDF

Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA, 2006, 103(18):6970-5. Abstract| PDF

Wellen KE, Hotamisligil, GS. Inflammation, stress, and diabetes. J Clin Invest, 2005, 115:1111-1119. Abstract | PDF

Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol Cell Bio 2005, 25(2): 706-715. Abstract | PDF

Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil, GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism, 2005, 1:107-119. Abstract| PDF

Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem, 2005, epublication. Abstract|PDF

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science, 2004, 306:457-61. Abstract | PDF

Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation, 2004, 110(11):1492-1498. Abstract | PDF

Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the Fatty Acid Binding Protein mal1 in obesity and insulin resistance. Diabetes, 2003, 52: 300-307. Abstract | PDF

Xu, H, Uysal, KT, Becherer, D, Arner, P, Hotamisligil, GS. ALTERED TNF a Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha a in obesity. Diabetes, 2002, 51:1876-1883. Abstract | PDF

Boord, JB, Maeda, K, Makowski, L, Babaev, VR, Fazio, S, Linton, MF, Hotamisligil, GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Art, Thro, Vasc Bio, 2002, 22:1686-1691. Abstract | PDF

Hirosumi, J, Tuncman, G, Chang, L, Gorgun, CZ, Uysal, KT, Maeda, K, Karin, M, Hotamisligil, GS. A central role for JNK in obesity and insulin resistance. Nature, 2002,420:333-336. Abstract | PDF

Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine. 7(6):699-705, 2001. Abstract|PDF

Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 290(5489):134-138, 2000. Abstract | PDF

Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA and Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Diabetes, 1999 Oct; 48:1987-1994. Abstract | PDF

Xu H, Sethi JK, Uysal KT, Wiesbrock SM, Scheja L and Hotamisligil GS. Transmembrane Tumor Necrosis Factor (TNF)-a Inhibits adipocyte differentiation by selectively activating TNF Receptor 1. J. Biol. Chem. 1999. 274(37):26287-26295. Abstract | PDF

Kirchgessner T, Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. Journal of Clinical Investigation 1997 Dec 1; 100(11): 2777-2782. Abstract | PDF

Uysal KT, Wiesbrock SM, Marino MW and Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997 Oct 9; 389(6651): 610-614. Abstract | PDF