THE SECOND INTERNATIONAL SYMPOSIUM ON PEDIATRIC AIDS IN THAILAND


March 24-26, 1997
Pornping Tower Hotel
Chiang Mai, Thailand

Sponsors:
Chiang Mai University, Thailand
Harvard AIDS Institute, USA
Mahidol University, Thailand
ORSTOM, France
Ministry of Public Health, Thailand

The Second International Symposium on Pediatric AIDS in Thailand was sponsored by the Harvard AIDS Institute, USA; Chiang Mai University, Mahidol University, and the Ministry of Public Health, Thailand; and ORSTOM, France. The sponsors gratefully acknowledge the Fogarty International Center of the US National Institutes of Health for its support of this symposium.

National Organizing Committee members for this symposium included Dr. Marc Lallemant, North Thailand Perinatal HIV Prevention Trial and Dr. Vicharn Vithayasai, Chiang Mai University.

The articles in this report are abstracts submitted by the authors or summaries of presentations made at the symposium. The report was edited by Jaklen Muoi Tuyen of the Yale School of Epidemiology and Public Health and produced by the Harvard AIDS Institute. For more information, contact the Harvard AIDS Institute at 651 Huntington Avenue, Boston, Massachusetts 02115, USA (telephone: 617-432-4400; fax: 617-432-4545).

TABLE OF CONTENTS

Status and Trends of the HIV/AIDS Epidemic
Demographic Impact
Nicolas Brouard
Epidemiology of HIV/AIDS in Southeast Asia and Thailand
Wiput Phoolcharoen
The HIV/AIDS Epidemic in the North: Epidemiology and Public Health
Vallop Thaineua
HIV Variation: Epidemiological, Clinical, and Public Health Implications
Max Essex
Current Knowledge About Perinatal Transmission
Mechanisms and Timing of Perinatal Transmission
Sophie Le Cœur
Perinatal HIV-1 Transmission Rate in Thailand
Virat Sirisanthana
Perinatal HIV Infection: Present Strategies for Prevention
Kenneth McIntosh
Interventions to Prevent Perinatal Transmission
Perinatal HIV Infection: The Pediatric ACTG Agenda
Kenneth McIntosh
Prevention of Perinatal Transmission: International Studies
Sophie Le Cœur
Update on the Bangkok Collaborative HIV Perinatal Short-Course ZDV Intervention Trial
Nathan Shaffer
Red Cross Perinatal Trials: Prevention of Vertical HIV-1 Transmission
P. Virutamasen, S. Limpongsanurak, K. Ruxrungtham, D. Reinprayoon, P. Phanuphak, U. Thisyakorn, Pimolrat Thaithumyanon, S. Likitnukul, M. Hanvanich, K. Sathapornpongse, S. Chuansanit, and S. Nimkarn
North Thailand Perinatal HIV Prevention Trial (NT-PHPT)
Marc Lallemant
Clinical Research Methods
Good Clinical Practice and International Research
Stephen Lagakos
The ICH Good Clinical Practice (GCP) Consolidated Guidelines
Gonzague Jourdain
Clinical Trial Networks in Thailand
Chaiyos Kunanusont
Role of the Thai FDA Concerning Clinical Research on HIV/AIDS Drugs and Vaccines in Thailand
Pakdee Pothisiri
Ethical Issues Raised by Research on Human Subjects in Thailand
Vichai Chokevivat
Quality Control and Quality Assurance
Günther Forster
Pharmacovigilance and the Pharmaceutical Industry
Sunettra Chinnapha
Population Pharmacokinetics and Pharmacodynamics of Zidovudine
France Mentré
Virology and Diagnostic Issues
The Use of Dried Blood Specimens for Diagnosis by DNA-PCR in HIV-At-Risk Infants
Anne Marie Comeau and Kenneth McIntosh
Nucleic Acid Amplification for Diagnosis and Monitoring of HIV-1Infection: A Workshop Report
Chantapong Wasi, Ruengpung Sutthent, and Wannee Kantakamalakul
V3 Loop Sequences Variability of HIV-1 Subtype-E in Perinatally HIV-Infected Children
Suporn Foongladda, Ruengpung Sutthent, Sanae Chearskul, Nirun Wanprapa, and Chantapong Wasi
NASBA-Based Quantification of RNA: Applications for HIV-1 and AIDS
M. G. Sarngadharan and J. W. Romano
Issues in Virological Diagnosis
Tun-Hou Lee
Vaccine Approaches
AIDS Vaccine Research: Approach to the Global Epidemic
Max Essex and Tun-Hou Lee
Thai National Policy on HIV Vaccines
Natth Bhamarapravati
Pediatric AIDS Vaccines
Shizuko Sei
Phase I Study to Evaluate the Safety and Immunogenicity of HIV-1 Immunogen in Children with HIV-1 Infection
S. Sei, S. Sandelli, D. Venzon, S. Jankelovich, L. Serchuck, S. Zeichner, P. Brouwers, S. Kim, M. Robb, G. Theofan, R. Moss, L. Wood
Clinical Manifestations in HIV-Infected Children
Pneumonia in HIV-Infected Infants
Kanchana Preedisripipat and Virat Sirisanthana
Hematological Manifestation in HIV-Infected Children
Pornwilai Aksorn, Virat Sirisanthana, and Panja Kulapongs
Renal Involvement in HIV-Infected Children
Watana Chartapisak, Virat Sirisanthana, and Sauwalak Opastirakul
Mucocutaneous Manifestations in Children with Acquired Immunodeficiency Syndrome
Chulabhorn Pruksachatkunakorn and Somporn Wangruangsathit
Oral Candidiasis in HIV-Infected Children
Kingkarn Chaijaroen and Chulabhorn Pruksachatkunakorn
Clinical Care for Women and Children with HIV
Pregnant Women with HIV
Anuvat Rungpisuthipong
Pediatric AIDS: Experience from Northern Thailand
Virat Sirisanthana
Management of HIV Infection in Adult and Pediatric Patients: New Antiretroviral Approaches
Richard Marlink
Management of HIV-Infected Children: HIV-RNA Measurement
Kenneth McIntosh
Social and Psychological Aspects of Perinatal Transmission
HIV Counseling in Maternal and Child Health
Soisaang Sethavanich
Orphans and Families Affected by HIV/AIDS
Vicharn Vithayasai and Prakong Vithayasai
Public Health and Policy Issues
Health Care System Issues
Somsak Chunharas
Impact of AIDS on Health Care Costs in Developing Countries
Donald Shepard
Beyond Clinical Trials: Operations Research
Donald Shepard
International Cooperation
Richard Marlink


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