Paper by Topic
Laeyendecker, O., Brookmeyer, R., Mullis, C., Donnell, D., Lingappa, J., Celum, C., Baeten, J.M., Campbell, M.S. , Essex, M., de Bruyn, G., Farquhar, C., Quinn, T.C., Eshleman, S. Specificity of four laboratory approaches for cross-sectional HIV incidence determination: Analysis of samples from adults with known non-recent HIV infection from five African countries. AIDS Res Hum Retroviruses. 2012 Jan 29.
Novitsky, V., Essex, M. Using HIV viral load to guide treatment-for-prevention interventions. Curr Opin HIV AIDS. 2012 Jan 16.
Novitsky, V., Wang, R., Baca, J., Margolin, L., McLane, MF., Moyo, S., van Widenfelt, E., Makhema, J., Essex, M. Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection. Virology. 2011 Oct 17.
Novitsky, V., Ndung’u, T., Wang, R., Bussmann, H., Chonco, F., Makhema, J., De Gruttola, V., Walker, B.D., Essex, M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS. Apr 18. (2011).
Novitsky, V., Wang, R., Margolin, L., Baca, J., Rossenkhan, R., Moyo, S., van Widenfelt, E., and Essex, M. Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection. PLoS One. 6:e16714 (2011).
Novitsky, V., Wang, R., Bussmann, H., Lockman, S., Baum, M., Shapiro, R., Thior, I., Wester, C., Wester, C.W., Ogwu, A., Asmelash, A., Musonda, R., Campa, A., Moyo, S., van Widenfelt, E., Mine, M., Moffat, C., Mmalane, M., Makhema, J., Marlink, R., Gilbert, P., Seage, G.R. 3rd, DeGruttola, V., and Essex, M. HIV-1 Subtype C Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission. PloS One. 5:e10148 (2010).
Novitsky, V., Wang, R., Margolin, L., Baca, J., Moyo, S., Musonda, R., and Essex, M. Dynamics and Timing of in Vivo Mutations at Gag Residue 242 during Primary HIV-1 Subtype C Infection. Virology. 403:37–46 (2010).
Novitsky, V., Wang, R., Kebaabetswe, L., Greenwald, J., Rossenkhan, R., Moyo, S., Musonda, R., Woldegabriel, E., Lagakos, S., and Essex, M. Better Control of Early Viral Replication Is Associated with Slower Rate of Elicited Antiviral Antibodies in the Detuned EIA during Primary HIV-1C Infection. J. Acquir. Immune Defic. Syndr. 52:265–272 (2009).
Novitsky, V., Lagakos, S., Herzig, M., Bonney, C., Kebaabetswe, L, Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel, E., van Widenfelt, E., Makhema, J., and Essex, M. Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47–59 (2009).
Novitsky, V., Woldegabriel, E., Kebaabetswe, L., Rossenkhan, R., Mlotshwa, B., Bonney, C., Herzig, M., Finucane, M., Musonda, R., Moyo, S., Wester, C., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Viral Load and CD4+ T Cell Dynamics in Primary HIV-1 Subtype C Infection. J. Acquir. Immune Defic. Syndr. 50:65–76 (2009).
Lockman, S., Creek, T. Acute maternal HIV infection during pregnancy and breast-feeding: substantial risk to infants. J Infect Dis. Sep 1;200(5):667-9. (2009)
Novitsky, V., Woldegabriel, E., Wester, C., McDonald, E., Rossenkhan, R., Ketunuti, M., Makhema, J., Seage, G.R, III, and Essex, M. Identification of Primary HIV-1C Infection in Botswana. AIDS Care. 20(7): 806-11 (2008).
Novitsky, V., Gaolath, T., Woldegabriel, E., Makhema, J., and Essex, M. A Seronegative Case of HIV-1 Subtype C Infection in Botswana. Clin. Infect. Dis 45:e68-71 (2007).
Brown, B.J., Oladokun, R.E., Osinusi, K., Ochigbo, S., Adewole, I.F., Kanki, P. Disclosure of HIV status to infected children in a Nigerian HIV Care Programme. AIDS Care. Apr 5:1-6 (2011)
Heidari, S., Mofenson, L.M., Hobbs, C.V., Cotton, M.F., Marlink, R., Katabira, E. Unresolved Antiretroviral Treatment Management Issues in HIV-Infected Children. J Acquir Immune Defic Syndr. 2011 Dec 1.
Matthews, L.T., Ribaudo, H.J., Parekh, N.K., Chen, J.Y., Binda, K., Ogwu, A., Makhema, J., Souda, S., Lockman, S., Essex, M., Shapiro, R.L. Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S-born black infants. BMC Pediatr. 2011 Dec 16;11(1):115.
Parekh, N., Ribaudo, H., Souda, S., Chen, J., Mmalane, M., Powis, K., Essex, M., Makhema, J., Shapiro, R.L. Risk factors for very preterm delivery and delivery of very-small-for-gestational-age infants among HIV-exposed and HIV-unexposed infants in Botswana. Int J Gynaecol Obstet. 2011 Jul 16.
MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).
Shapiro, R.L., Lockman, S. Mortality among HIV-exposed infants: the first and final frontier. Clin Infect Dis. Feb 1;50(3):445-7. (2010)
Lockman, S., Creek, T. Acute maternal HIV infection during pregnancy and breast-feeding: substantial risk to infants. J Infect Dis. Sep 1;200(5):667-9. (2009)
Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Van-Dyke, RB., Seage, GR, 3rd., Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin. Infect. Dis. Feb 15; 46(4): 507-15 (2008)
Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Dyke, RB., Seage, GR, 3rd. Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin. Infect. Dis. Jun 1; 46(11): 1751-60 (2008)
Williams, PL., Van-Dyke, R., Eagle, M., Smith, D., Vincent, C., Ciupak, G., Oleske, J., Seage, GR, 3rd. Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study. Am. J. Epidemiol. Jun 1; 167(11): 1375-86 (2008)
Brogly, SB., Ylitalo, N., Mofenson, LM., Oleske, J., Van-Dyke, R., Crain, MJ., Abzug, MJ., Brady, M., Jean-Philippe, P., Hughes, MD., Seage, GR, 3rd. In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children. AIDS. May 11; 21(8): 929-38 (2007)
Lin, N.H., Negusse, D.M., Beroukhim, R., Giguel, F., Lockman, S., Essex, M., and Kuritzkes, D.R. The Design and Validation of a Novel Phenotypic Assay to Determine HIV-1 Coreceptor Usage of Clinical Isolates. J Virol Methods. 169:39–46 (2010).
Lingappa., J.R., Baeten, J.M., Wald, A., Hughes, J.P., Thomas, K.T., Mujugira, A., Mugo, N., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Steward, G.J., Makehma, J., Essex, M., Were, E., Fife, K.H., de Bruyen, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Magaret, A.S., Wang, R.S., Kidoguchi, L., Barnes, L., Ridzon, R., Corey, L., and Celum, C. for the Partners in Prevention HSV/HIV Transmission Study Team. Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet. 375: 824-833. (2010)
Novitsky, V., Wang, R., Margolin, L., Baca, J., Kebaabetswe, L., Rossenkhan, R., Bonney, C., Herzig, M., Nkwe, D., Moyo, S., Musonda, R., Woldegabriel, E., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Timing Constraints of in Vivo Gag Mutations during Primary HIV-1 Subtype C Infection. PLoS One. 4:e7727 (2009).
Novitsky, V., Wang, R., Kebaabetswe, L., Greenwald, J., Rossenkhan, R., Moyo, S., Musonda, R., Woldegabriel, E., Lagakos, S., and Essex, M. Better Control of Early Viral Replication Is Associated with Slower Rate of Elicited Antiviral Antibodies in the Detuned EIA during Primary HIV-1C Infection. J. Acquir. Immune Defic. Syndr. 52:265–272 (2009).
Essex, M., and Lu, Y. HIV/AIDS: Lessons from a New Disease Pandemic. In: Emerging Infections in Asia. Lu, Y., Essex, M., and Roberts, B., eds. New York: Springer, pp. 133-142 (2008).
Kuritzkes, DR. HIV-1 subtype as a determinant of disease progression. J. Infect. Dis. Mar 1; 197(5): 638-9 (2008)
Antelman, G., Kaaya, S., Wei, R., Mbwambo, J., Msamanga, GI., Fawzi, WW., Fawzi, MC. Depressive symptoms increase risk of HIV disease progression and mortality among women in Tanzania. JAIDS. Apr 1; 44(4): 470-7 (2007)
MacNeil, A., Sankale, JL., Meloni, ST., Sarr, AD., Mboup, S., Kanki, P. Long-term intrapatient viral evolution during HIV-2 infection. J. Infect. Dis. Mar 1; 195(5): 726-33 (2007)
MacNeil, A., Sankale, JL., Meloni, ST., Sarr, AD., Mboup, S., Kanki, P. Direct evidence of lower viral replication rates in vivo in human immunodeficiency virus type 2 (HIV-2) infection than in HIV-1 infection. J. Virol. May; 81(10): 5325-30 (2007)
Redd, A. D., Avalos, A., Phiri, K., and Essex, M. Infection of Hematopoietic Progenitor Cells by HIV-1 Subtype C, and Its Association with Anemia in Southern Africa. Blood 110:3143-3149 (2007).
Redd, A. D., Avalos, A., Phiri, K., and Essex, M. Effects of HIV Type 1 Infection on Hematopoiesis in Botswana. AIDS Res. Hum. Retroviruses. 23:996-1003 (2007).
Jayeoba, O., Dryden-Peterson, S., Okui, L., Smeaton, L., Magetse, J., Makori, L., Modikwa, V., Mogodi, M., Plank, R., Lockman, S. Acceptability of Male Circumcision Among Adolescent Boys and their Parents, Botswana. AIDS Behav. Mar 25 (2011).
Kebaabetswe, P., Ndase, P., Mujugira, A., Sekoto, T., Ntshimane, M., Owor, A., Makhema, J., Thior, I., and Essex, M. Perceptions of couple HIV counseling and testing in Botswana: A stakeholder analysis. Patient Educ. Couns. 79:120–3 (2010).
Plank, R.M., Makhema, J., Kebaabetswe, P., Hussein, F., Leseidi, C., Halperinm D., Bassil, B., Shapiro, R., Lockman, S. Acceptability of infant male circumcision as part of HIV prevention and male reporductive health efforts in Gaborone, Botswana, and surrounding areas. AIDS Behav. Oct;14(5):1198-202. (2010)
Fisher, JC., Cook, PA., Sam, NE., Kapiga, SH. Patterns of alcohol use, problem drinking, and HIV infection among high-risk African women. Sex. Transm. Dis. Jun; 35(6): 537-44 (2008)
Frosythe S, Bertozzi S, Moatti JP, Marlink R, Luchini S, Kazatchkine M. I. Infoming scale-up and resource allocation: the use of economic analysis. II. Universal Access to HIV Treatment in Developing Countries: Going Beyond the Misinterpretations of the “Cost-effectiveness” Algorithm. III. The Economic Impact of HIV/AIDS on households and economies. AIDS, Volume 22 Suppl 1:S5-S6, S59-S66, S87-S88. July 2008.
Martinez, P., Andia, I., Emenyonu, N., Hahn, J A., Hauff, E., Pepper, L., Bangsberg, DR. Alcohol use, depressive symptoms and the receipt of antiretroviral therapy in southwest Uganda. AIDS-Behav. Jul; 12(4): 605-12 (2008)
Fisher, JC., Bang, H., Kapiga, SH. The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies. Sex. Transm. Dis Nov; 34(11): 856-63
(2007)
Ciaranello, A.L., Lockman, S., Freedberg, K.A., Hughes, M., Chu, J., Currier, J., Wood, R., Holmes, C.B., Pillay, S., Conradie, F., McIntyre, J., Losina, E., Walensky, R.P.; for the CEPAC-International and OCTANE Investigators. First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effictiveness anaylysis of the OCTANE trial. AIDS. Feb 20.25(4):479-492. (2011)
Chigwedere, P. and Essex, M. AIDS Denialism and Public Health Practice. AIDS Behav. 2010. Epub 8 January 2010.
Bussmann, C., Rotz, P., Ndwapi, N., Baxter, D., Bussmann, Hi., Wester, W.C., Ncube, P., Avalos, A., Mine, M., Mabe, E., Burns, P.J., Cardiello, P., Makehma, J., Marlink, R. Strengthening Healthcard Capacity Through a Responsive, Country-Specific, Training Standard: The KITSO AIDS Training Program’s Support of Botswana’s National Antiretroviral Therapy Rollout. The Open AIDS Journal, 2:8-20 (2008)
Marlink, R., Forsythe, S., Bertozzi, SM., Muirhead, D., Holmes, M., Sturchio, J. Re: This special issue of AIDS–a mix of recent economic analyses and commentary on how best to distill economic insights to improve HIV/AIDS policies and programmes. AIDS. Jul; 22 Suppl 1: S1-4
(2008)
Marlink, R., Forsythe, S., Bertozzi, SM., Muirhead, D., Holmes, M., Sturchio, J. Informing scale-up and resource allocation: the use of economic analysis. AIDS. Jul; 22 Suppl 1: S5-6 (2008)
Marlink, R., Forsythe, S., Bertozzi, SM., Muirhead, D., Holmes, M., Sturchio, J. The economic impacts of HIV/AIDS on households and economies. AIDS. Jul; 22 Suppl 1: S87-8 (2008)
Moatti, JP., Marlink, R., Luchini, S., Kazatchkine, M. Universal access to HIV treatment in developing countries: going beyond the misinterpretations of the ‘cost-effectiveness’ algorithm. AIDS. Jul; 22 Suppl 1: S59-66 (2008)
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Finucane MM, Rowley CF, Paciorek CJ, Essex M, Pagano M. Estimating the prevalence of transmitted HIV drug resistance using pooled samples. Stat Methods Med Res. 2013 Feb 1
Rawizza, H.E., Chaplin, B., Meloni, S.T., Eisen, G., Rao, T., Sankalé, J.L., Dieng-Sarr, A., Agbaj,i O., Onwujekwe, D.I., Gashau, W., Nkado, R., Ekong, E., Okonkwo, P., Murphy, R.L., Kanki, P.J.; for the APIN PEPFAR Team. Immunologic Criteria Are Poor Predictors of Virologic Outcome: Implications for HIV Treatment Monitoring in Resource-Limited Settings. Clin Infect Dis. 2011 Dec;53(12):1283-1290.
Armstrong, K.L., Lee, T.H., Essex, M. The Replicative Fitness Costs of Non-Nucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C. Antimicrob Agents Chemother. 2011 Mar 14.
Baeten, J.M., Lingappa, J., Beck., I., Freukel, L., Pepper, G., Wald, A., Fife, K., Were, E., Mugo, N., Sanchez, J., Essex, M., Makhema, J., Kiare, J., Farquhar, C., Corey, L., and Celum, C. Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV 1/HSV-2 Dually Infected Persons. J. Infect. Dis. 203:117–21 (2011).
Bussmann, H., de la Hoz Gomez, F., Roels, T.H., Wester, C.W., Bodika, S.M., Moyo, S., Taffa, N., Anderson, M.G., Mine, M., Bile, E.C., Yang, C., Mphoyakgosi, K., Lehotzky, E.A., Mlotshwa, B., Mmelesi, M., Seipone, K., Makhema, M.J., Marlink, R.G., Novitsky, V., Essex, M. Prevalence of transmitted HIV drug resistance in Botswana: lessons learned from the HIVDR-Threshold Survey conducted among women presenting for routine antenatal care as part of the 2007 national sentinel survey. AIDS ResHum Retroviruses. Apr;27(4):365-72. (2011)
Rowley, C.F., Boutwell, C.L., Lee, E.J., MacLeod, I.J., Ribaudo, H.J., Essex, M, and Lockman, S. Ultrasensitive Detection of Minor Drug-Resistant Variants for HIV after Nevirapine Exposure Using Allele-Specific PCR: Clinical Significance. AIDS Res. Hum. Retroviruses. 26:293–300 (2010).
Wester, C.W., Thomas, A.M., Bussmann, H., Moyo, S., Makhema, J.M., Gaolathe, T., Novitsky, V., Essex, M., DeGruttola, V., and Marlink, R.G. Non-nucleoside reverse transcriptase inhibitor outcomes among combination antiretroviral therapy-treated adults in Botswana. AIDS. Suppl 1:S27–36 (2010).
Armstrong, K.L., Lee, TH, and Essex, M. Replicative Capacity Differences of Thymidine Analog Resistance Mutations in Subtype B and C Human Immunodeficiency Virus Type 1. J. Virol. 83: 4051-4059 (2009)
Doualla-Bell, F., Gaolathe, T., Avalos, A., Cloutier, S., Ndwapi, N., Holcroft, C., Moffat., H., Dickinson, D., Essex, M., Wainberg, M.A., Mine, M. Five-year followu up of genotypic resistance pattersn in HIV-1 subtupe C infected patients in Botwswana after failure of thymidine analogue-based regimens. J. of International AIDS Society. 12:25. (2009)
Assoumou, L., Brun-Vezinet, F., Cozzi-Lepri, A., Kuritzkes, D., Phillips, A., Zolopa, A., Degruttola, V., Miller, V., Costagliola, D. Initiatives for developing and comparing genotype interpretation systems: external validation of existing systems for didanosine against virological response. J. Infect. Dis. Aug 15; 198(4): 470-80 (2008)
Bangsberg, DR. Preventing HIV antiretroviral resistance through better monitoring of treatment adherence. J. Infect. Dis. May 15; 197 Suppl 3: S272-8 (2008)
Bangsberg, DR. A paradigm shift to prevent HIV drug resistance. PLoS Med. May 20; 5(5): e111 (2008)
Kuritzkes, DR., Lalama, CM., Ribaudo, HJ., Marcial, M., Meyer, WA, 3rd; Shikuma, C., Johnson,V A., Fiscus, SA., D’Aquila, RT., Schackman, BR., Acosta, EP., Gulick, RM. Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects. J. Infect. Dis. Mar 15; 197(6): 867-70 (2008)
Marconi, VC., Sunpath, H., Lu, Z., Gordon, M., Koranteng-Apeagyei, K., Hampton, J., Carpenter, S., Giddy, J., Ross, D., Holst, H., Losina, E., Walker, BD., Kuritzkes, DR. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin. Infect. Dis. May 15; 46(10): 1589-97 (2008)
Parienti, JJ., Das-Douglas, M., Massari, V., Guzman, D., Deeks, SG., Verdon, R., Bangsberg, DR. Not all missed doses are the same: sustained NNRTI treatment interruptions predict HIV rebound at low-to-moderate adherence levels. PLoS ONE. 3(7): e2783 (2008)
Rowley, C.F., Boutwell, C.L., Lockman, S., and Essex, M. Improvement in Allele-Specific PCR Assay with the Use of Polymorphism-Specific Primers for the Analysis of Minor Variant Drug Resistance in HIV-1 subtype C. J. Virol. Methods.149:69–75 (2008).
Schumi, J., Degruttola, V. Resampling-based analyses of the effects of combinations of HIV genetic mutations on drug susceptibility. Stat. Med. Oct 15; 27(23): 4740-57 (2008)
Tsibris, AM., Sagar, M., Gulick, RM., Su, Z., Hughes, M., Greaves, W., Subramanian,M., Flexner, C., Giguel, F., Leopold, KE., Coakley, E., Kuritzkes, DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J. Virol. Aug; 82(16): 8210-4 (2008)
Yang, Y., Degruttola, V. Resampling-based multiple testing methods with covariate adjustment: application to investigation of antiretroviral drug susceptibility. Biometrics. Jun; 64(2): 329-36 (2008)
Healy, B., Degruttola, V. Hidden Markov models for settings with interval-censored transition times and uncertain time origin: application to HIV genetic analyses. Biostatistics. Apr; 8(2): 438-52 (2007)
Novitsky, V., Wester, C. W., De Gruttola, V., Bussmann, H., Gaseitsiwe, S., Thomas, A., Moyo, S., Musonda, R., van Widenfelt, E., Marlink, R. G., and Essex, M. The Reverse Transcriptase 67N 70R 215Y Genotype Is the Predominant TAM Pathway Associated with Virologic Failure among HIV Type 1C-Infected Adults Treated with ZDV/ddI-Containing HAART in Southern Africa. AIDS Res. Hum. Retroviruses. 23:868-878 (2007).
Ojesina, AI., Mullins, C., Imade, G., Samuels, J., Sankale, JL., Pam, S., Sagay, S., Idoko, J., Kanki, PJ. Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria. AIDS. Res. Hum. Retroviruses. Dec; 23(12): 1587-92 (2007)
Oyugi, J H., Byakika-Tusiime, J, Ragland, K., Laeyendecker, O., Mugerwa, R., Kityo, C., Mugyenyi, P., Quinn, TC., Bangsberg, D R. Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda. AIDS. May 11; 21(8): 965-71 (2007)
Paredes, R., Marconi, VC., Campbell, TB., Kuritzkes, DR. Systematic evaluation of allele-specific real-time PCR for the detection of minor HIV-1 variants with pol and env resistance mutations. J. Virol. Methods. Dec; 146(1-2): 136-46 (2007)
Petersen, ML., Wang, Y., van-der-Laan, MJ., Guzman, D., Riley, E., Bangsberg, DR. Pillbox organizers are associated with improved adherence to HIV antiretroviral therapy and viral suppression: a marginal structural model analysis. Clin. Infect. Dis. Oct 1; 45(7): 908-15 (2007)
Brenner, B.G., Oliveira, M., Doualla-Bell, F., Moisi, D.D., Ntemgwa, M., Frankel, F., Essex, M., and Wainberg, M.A. HIV-1 Subtype C Viruses Rapidly Develop K65R Resistance to Tenofovir in Cell Culture. AIDS. 20:F9-F13 (2006).
Doualla-Bell, F., Avalos, A., Brenner, B., Gaolathe, T., Mine, M., Gaseitsiwe, S., Oliveira, M., Moisi, D., Ndwapi, N., Moffat, H., Essex, M., and Wainberg, M.A. High Prevalence of the K65R Mutation in Human Immunodeficiency Virus Type 1 Subtype C Isolates from Infected Patients in Botswana Treated with Didanosine-Based Regimens. Antimicrob. Agents Chemother. 50:4182-4185 (2006).
Doualla-Bell, F., Avalos, A., Gaolathe, T., Mine, M., Gaseitsiwe, S., Ndwapi, N., Novitsky, V., Brenner, B., Oliveira, M., Moisi, D., Moffat, H., Thior, I, Essex, M., and Wainberg, M.A. Impact of Human Immunodeficiency Virus Type 1 Subtype C on Drug Resistance Mutations in Patients from Botswana Failing a Nelfinavir-Containing Regimen. Antimicrob. Agents Chemother.50:2210-2213 (2006).
Maier, M., Bwana, M., Emenyonu, N., Pepper, L., Bangsberg, DR. How to Take HIV antiretroviral medications on time without a watch in rural Uganda. PLoS. Med. Mar; 3(3): e161 (2006)
Mills, EJ., Nachega, JB., Buchan, I., Orbinski, J., Attaran, A., Singh, S., Rachlis, B., Wu, P., Cooper, C., Thabane, L., Wilson, K., Guyatt, GH., Bangsberg, D R. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. Aug 9; 296(6): 679-90 (2006)
Ojesina, AI., Sankale, JL., Odaibo, G., Langevin, S., Meloni, ST., Sarr, AD., Olaleye, D., Kanki, PJ. Subtype-specific patterns in HIV Type 1 reverse transcriptase and protease in Oyo State, Nigeria: implications for drug resistance and host response. AIDS. Res. Hum. Retroviruses. Aug; 22(8): 770-9 (2006)
Teeravechyan, S., Essex, M., and Lee, T.H. Conserved Determinants of Enhanced CCR5 Binding in the Human Immunodeficiency Virus Subtype D Envelope Third Variable Loop. AIDS Res. Hum. Retroviruses. 26:481–8 (2010).
Teeravechyan, S., Suphaphiphat, P., Essex, M., and Lee, T.H. Relative Concordance of Human Immunodeficiency Virus Oligomeric and Monomeric Envelope in CCR 5 Coreceptor Usage. Virology. 340:443-450 (2008).
Suphaphiphat, P., Essex, M., and Lee, T.H. Mutations in the V3 Stem versus the V3 Crown and C4 Region Have Different Effects on the Binding and Fusion Steps of Human Immunodeficiency Virus Type 1 Gp120 Interaction with the CCR5 Coreceptor. Virology. 360:182-190 (2007).
Trujillo, J.R., Rogers, R., Molina, R., Dangond, F., McLane, M.F., Essex, M., and Brain, J. Noninfectious Entry of HIV-1 into Peripheral and Brain Macrophages Mediated by the Mannose Receptor. Proc. Natl. Acad. Sci. U.S.A. 104:5097-5102 (2007).
Novitsky, V., Wang, R., Margolin, L., Baca, J., Rossenkhan, R., Moyo, S., van Widenfelt, E., and Essex, M. Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection. PLoS One. 6:e16714 (2011).
Lingappa, J.R., Hughes, J.P., Wang, R.S., Baeten, J.M., Celum, C., Gray, G.E., Stevens, W., Donnell, D., Campbell, M.S., Farquhar, C., Essex, M., Mullins, J.I., Coombs, R.W., Rees, H., Corey, L., and Wald, A. for the Partners in Prevention HSV/HIV Transmission Study Team. Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk. PLoS One.5:e12598. (2010)
Novitsky, V., Wang, R., Bussmann, H., Lockman, S., Baum, M., Shapiro, R., Thior, I., Wester, C., Wester, C.W., Ogwu, A., Asmelash, A., Musonda, R., Campa, A., Moyo, S., van Widenfelt, E., Mine, M., Moffat, C., Mmalane, M., Makhema, J., Marlink, R., Gilbert, P., Seage, G.R. 3rd, DeGruttola, V., and Essex, M. HIV-1 Subtype C Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission. PloS One. 5:e10148 (2010).
Novitsky, V., Wang, R., Lagakos, S., and Essex, M. HIV-1 Subtype C Phylodynamics in the Global Epidemic. Viruses. 2:33–54 (2010).
Essex, M., and Lu, Y. HIV/AIDS: Lessons from a New Disease Pandemic. In: Emerging Infections in Asia. Lu, Y., Essex, M., and Roberts, B., eds. New York: Springer, pp. 133-142 (2008).
Msisha, WM., Kapiga, S H., Earls, F J. Subramanian,-S-V. Place matters: multilevel investigation of HIV distribution in Tanzania. AIDS. Mar 30; 22(6): 741-8 (2008)
Drain, PK., Kupka, R., Msamanga, GI., Urassa, W., Mugusi, F., Fawzi, WW. C-reactive protein independently predicts HIV-related outcomes among women and children in a resource-poor setting. AIDS. Oct 1; 21(15): 2067-75 (2007)
Hamel, DJ., Sankale, JL., Eisen, G., Meloni, ST., Mullins, C., Gueye-Ndiaye, A., Mboup, S., Kanki, PJ. Twenty Years of Prospective Molecular Epidemiology in Senegal: Changes in HIV Diversity.
AIDS. Res. Hum. Retroviruses. Oct; 23(10): 1189-96 (2007)
Larsen, U., Mlay, J., Aboud, S., Ballard, R., Sam, NE., Shao, JF., Kapiga, SH. Design of a community-based study of sexually transmitted infections/HIV and infertility in an urban area of northern Tanzania. Sex. Transm. Dis. Jan; 34(1): 20-4 (2007)
Sankale, JL., Langevin, S., Odaibo, G., Meloni, ST., Ojesina, AI., Olaleye, D., Kanki, P. The complexity of circulating HIV type 1 strains in Oyo state, Nigeria. AIDS. Res. Hum. Retroviruses. Aug; 23(8): 1020-5 (2007)
Vasan, A., Renjifo, B., Hertzmark, E., Chaplin, B., Msamanga, G., Essex, M., Fawzi, W., and Hunter, D. Different Rates of Disease Progression of HIV Type 1 Infection in Tanzania Based on Infecting Subtype. Clin. Infect. Dis. 42:843-852 (2006).
Genetics of Susceptibility to HIV
Lingappa, J.R., Petrovski, S., Kahle, E., Fellay, J., Shianna, K., McElrath, M.J., Thomas, K.K., Baeten, J.M., Celum, C., Wald, A., de Bruyn, G., Mullins, J.I., Nakku-Joloba, E., Farquhar, C., Essex, M., Donnell, D., Kiarie, J., Haynes, B., Goldstein, D.; for the Partners in Prevention HSV/HIV Transmission Study Team .Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure. PLoS One. 2011;6(12):e28632. Epub 2011 Dec 12.
Hendrickson, SL., Jacobson, LP., Nelson, GW., Phair, JP., Lautenberger, J., Johnson, RC., Kingsley, L., Margolick, JB., Detels, R., Goedert, JJ., O’Brien, SJ. Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival. JAIDS. Jul 1; 48(3): 263-71 (2008)
Hutcheson, HB., Lautenberger, JA., Nelson, GW., Pontius, JU., Kessing, BD., Winkler, CA., Smith, MW., Johnson, R., Stephens, R., Phair, J., Goedert, JJ., Donfield, S., O’Brien, SJ. Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery. Vaccine. Jun 6; 26(24): 2951-65 (2008)
An, P., Wang, LH., Hutcheson-Dilks, H., Nelson, G., Donfield, S., Goedert, JJ., Rinaldo, CR., Buchbinder, S., Kirk, G.,D; O’Brien, SJ., Winkler, CA. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. PLoS. Pathog. Jun; 3(6): e88 (2007)
Montano, M., Rarick, M., Sebastiani, P., Brinkmann, P., Russell, M., Navis, A., Wester, C., Thior, I., and Essex, M. Gene-Expression Profiling of HIV-1 Infection and Perinatal Transmission in Botswana. Genes Immun. 7:298-309 (2006).
Baeten, J.M., Lingappa, J., Beck., I., Freukel, L., Pepper, G., Wald, A., Fife, K., Were, E., Mugo, N., Sanchez, J., Essex, M., Makhema, J., Kiare, J., Farquhar, C., Corey, L., and Celum, C. Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV 1/HSV-2 Dually Infected Persons. J. Infect. Dis. 203:117–21 (2011).
Celum, C., Wald, A., Lingappa, J.R., Magaret, A.S., Wang, R.S., Mugo, N., Mujugira, A., Baeten, J.M., Mullins, J.I., Hughes, J.P., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were, E., Fife, K.H., de Bruyn, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Stevens, W., Campbell, M.S., Thomas, K.K., Coombs, R.W., Morrow, R., Whittington, W.L.H., McElrath, M.J., Barnes, L., Ridzon, R., and Corey, L., for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. N Engl J Med. 362:427 (2010).
Lingappa., J.R., Baeten, J.M., Wald, A., Hughes, J.P., Thomas, K.T., Mujugira, A., Mugo, N., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Steward, G.J., Makehma, J., Essex, M., Were, E., Fife, K.H., de Bruyen, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Magaret, A.S., Wang, R.S., Kidoguchi, L., Barnes, L., Ridzon, R., Corey, L., and Celum, C. for the Partners in Prevention HSV/HIV Transmission Study Team. Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet. 375: 824-833. (2010)
Lingappa, J.R., Kahle E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were E., Fife K., deBruyn, G., Gray, G., McIntyre, J., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Coombs, R.W., Morrow, R., Whittington, W., Corey, L., Wald, A., and Celum, C., for the Partners HSV-2/HIV-1 Transmission Study Team. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE. 4:e5272 (2009).
Kapiga, S.H., Sam, N.E., Bang, H., Ni, Q., Ao, T.T.H., Kiwelu, I., Chiduo, S., Ndibe, U., Seage, G. III, Coplan, P., Shao, J., Rosenberg, Z.F., and Essex, M. The Role of Herpes Simplex Virus Type 2 and Other Genital Infections in the Acquisition of HIV-1 among High-Risk Women in Northern Tanzania. J. Infect. Dis. 195:1260-1269 (2007).
Tassiopoulos, K.K., Seage, G., III, Sam, N., Kiwelu, I., Shao, J., Ao, T.T.H., Essex, M., Coplan, P., Rosenberg, Z., Hughes, M., and Kapiga, S. Predictors of Herpes Simplex Virus Type 2 Prevalence and Incidence among Bar and Hotel Workers in Moshi, Tanzania. J. Infect. Dis. 195:493-501 (2007).
Highly Active Anti-Retroviral Therapy (HAART) Treatment
Wester CW, Eden SK, Shepherd BE, Bussmann H, Novitsky V, Samuels DC, Hendrickson SL, Winkler CA, O’Brien SJ, Essex M, D’Aquila RT, Degruttola V, Marlink RG. Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in botswana: results from a clinical trial. AIDS Res Hum Retroviruses. 2012 Aug 28.
Wester, C.W., Stitelman, O.M., Degruttola, V., Bussmann, H., Marlink, R.G., van der Laan, M.J. Effect Modification by Sex and Baseline CD4+ Cell Count Among Adults Receiving Combination Antiretroviral Therapy in Botswana: Results from a Clinical Trial. AIDS Res Hum Retroviruses. 2012 Feb 6.
Novitsky, V., Essex, M. Using HIV viral load to guide treatment-for-prevention interventions. Curr Opin HIV AIDS. 2012 Jan 16.
Lockman, S., Sax, P. Treatment-for-prevention: clinical considerations. Curr Opin HIV AIDS. 2012 Jan 5.
Rawizza, H.E., Chaplin, B., Meloni, S.T., Eisen, G., Rao, T., Sankalé, J.L., Dieng-Sarr, A., Agbaj,i O., Onwujekwe, D.I., Gashau, W., Nkado, R., Ekong, E., Okonkwo, P., Murphy, R.L., Kanki, P.J.; for the APIN PEPFAR Team. Immunologic Criteria Are Poor Predictors of Virologic Outcome: Implications for HIV Treatment Monitoring in Resource-Limited Settings. Clin Infect Dis. 2011 Dec.
Ciaranello, A.L., Lockman, S., Freedberg, K.A., Hughes, M., Chu, J., Currier, J., Wood, R., Holmes, C.B., Pillay, S., Conradie, F., McIntyre, J., Losina, E., Walensky, R.P.; for the CEPAC-International and OCTANE Investigators. First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effictiveness anaylysis of the OCTANE trial. AIDS. Feb 20.25(4):479-492. (2011)
Powis, K.M., Smeaton, L., Ogwu, A., Lockman, S. Dryden-Peterson, S., van Widenfelt, E., Leidner, J., Makhema, J., Essex, M., and Shapiro, R.L. Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. JAIDS. 1:56(2):131–8. (2011)
Wester, C.W., Koethe, J.R., Shepherd, B.E., Stinnette, S.E., Rebeiro, P.F., Kipp, A..M., Hong, H., Bussmann, H., Gaolathe, T., McGowan, C.C., Sterling, T.R., Marlink, R.G Non-AIDS Defining Events Among HIV-1 Infected Adults Receiving Combination Antiretroviral Therapy In Urban Settings in Sub-Saharan Africa and the United States. AIDS. May 12. (2011) [Epub ahead of print]
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J. Acquir. Immune Defic. Syndr. 54:102–6 (2010).
MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).
Rowley, C.F., Boutwell, C.L., Lee, E.J., MacLeod, I.J., Ribaudo, H.J., Essex, M, and Lockman, S. Ultrasensitive Detection of Minor Drug-Resistant Variants for HIV after Nevirapine Exposure Using Allele-Specific PCR: Clinical Significance. AIDS Res. Hum. Retroviruses. 26:293–300 (2010).
Shapiro, R., Hughes, M., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Snowden, W., Martinez-Tristani, M., Mazhani, L., Essex, M. Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010).
Wester, C.W., Thomas, A.M., Bussmann, H., Moyo, S., Makhema, J.M., Gaolathe, T.,Novitsky, V., Essex, M., DeGruttola, V., and Marlink, R.G. Non-nucleoside reverse transcriptase inhibitor outcomes among combination antiretroviral therapy-treated adults in Botswana. AIDS. Suppl 1:S27–36 (2010).
Bussmann, H., Wester, C.W., Thomas, A., Novitsky, V., Okezie, R., Muzenda, T., Gaolathe, T., Ndwapi, N., Mawoko, N., Widenfelt, E., Moyo, S., Musonda, R., Mine, M., Makhema, J., Moffat, H., Essex, M., DeGruttola, V., and Marlink, R.G. Response to Zidovudine/Didanosine-Containing Combination Antiretroviral Therapy Among HIV-1 Subtype C-Infected Adults in Botswana: Two-Year Outcomes from a Randomized Clinical Trial. J Acquir Immune Defic Syndr. 51:37–46 (2009).
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J Acquir Immune Defic Syndr. Epub 27 October 2009.
Shipton, L.K., Wester, C.W., Stock, S., Ndwapi, N., Gaolathe, T., Thior, I., Avalos, A., Moffat, H.J., Mboya J.J., Widenfelt, E., Essex, M., Hughes, M.D., and Shapiro, R.L. Safety and Efficacy of Nevirapine and Efavarinz-Based Antiretroviral Treatment in Adults Treated for TB-HIV Co-Infection in Botswana. Int. J. Tuberc. Lung Dis. 13:360–366 (2009).
Wester, C.W., Bussmann, H., Koethe, J., Moffat, C., Vermund, S., Essex, M., and Marlink, R.G. Adult Combination Antiretroviral Therapy in Sub-Saharan Africa: Lessons from Botswana and Future Challenges. HIV Ther. 3:501–526 (2009).
Bussmann, H., Wester, C.W., Ndwapi, N., Grundmann, N., Gaolathe, T., Puvimanasinghe, J., Avalos, A., Mine, M., Seipone, K., Essex, M., deGruttola, V., and Marlink, R.G. Five-Year Outcomes of Initial Patients Treated in Botswana’s National Antiretroviral Treatment Program. AIDS. 22:2303–2311 (2008).
Hendrickson, SL., Jacobson, LP., Nelson, GW., Phair, JP., Lautenberger, J., Johnson, RC., Kingsley, L., Margolick, JB., Detels, R., Goedert, JJ., O’Brien, SJ. Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival. JAIDS. Jul 1; 48(3): 263-71 (2008)
Hughes, MD., Ribaudo, HR. The search for data on when to start treatment for HIV infection. J. Infect. Dis. Apr 15; 197(8): 1084-6 (2008)
Marconi, V., Bonhoeffer, S., Paredes, R., Lu, J., Hoh, R., Martin, JN., Deeks, SG., Kuritzkes, DR. Viral dynamics and in vivo fitness of HIV-1 in the presence and absence of enfuvirtide. JAIDS. Aug 15; 48(5): 572-6 (2008)
Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Van-Dyke, RB., Seage, GR, 3rd., Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin. Infect. Dis. Feb 15; 46(4): 507-15 (2008)
Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Dyke, RB., Seage, GR, 3rd. Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin. Infect. Dis. Jun 1; 46(11): 1751-60 (2008)
Williams, PL., Van-Dyke, R., Eagle, M., Smith, D., Vincent, C., Ciupak, G., Oleske, J., Seage, GR, 3rd. Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study. Am. J. Epidemiol. Jun 1; 167(11): 1375-86 (2008)
Briand, N., Lallemant, M., Jourdain, G., Techapalokul, S., Tunthanathip, P., Suphanich, S., Chanpoo, T., Traisathit, P., McIntosh, K., Le-Coeur, S. Haematological safety of perinatal zidovudine in pregnant HIV-1-infected women in Thailand: secondary analysis of a randomized trial. PLoS Clin. Trials. 2(4): e11 (2007)
Brogly, SB., Ylitalo, N., Mofenson, LM., Oleske, J., Van-Dyke, R., Crain, MJ., Abzug, MJ., Brady, M., Jean-Philippe, P., Hughes, MD., Seage, GR, 3rd. In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children. AIDS. May 11; 21(8): 929-38 (2007)
Bussmann, H., Wester, C.W., Wester, C.N., Lekoko, B., Okezie, O., Thomas, A.M., DeGruttola, S.M.V., Makhema, J., Essex, M., and Marlink, R.G. Pregnancy Rates and Birth Outcomes among Women on Efavirenz-Containing Highly Active Antiretroviral Therapy in Botswana. J. Acquir. Immune Defic. Syndr. 45:269-273 (2007).
Deeks, SG., Lu, J., Hoh, R., Neilands, TB., Beatty, G., Huang, W., Liegler, T., Hunt, P., Martin, JN., Kuritzkes, DR. Interruption of enfuvirtide in HIV-1 infected adults with incomplete viral suppression on an enfuvirtide-based regimen. J. Infect. Dis. Feb 1; 195(3): 387-91 (2007)
Flynn, PM., Rudy, BJ., Lindsey, JC., Douglas, SD., Lathey, J., Spector, SA., Martinez, J., Silio, M., Belzer, M., Friedman, L., D’Angelo, L., Smith, E., Hodge, J., Hughes, MD. Long-term observation of adolescents initiating HAART therapy: three-year follow-up. AIDS. Res. Hum. Retroviruses. Oct; 23(10): 1208-14 (2007)
Gulick, RM., Lalama, CM., Ribaudo, HJ., Shikuma, CM., Schackman, BR., Schouten, J., Squires, KE., Koletar, SL., Pilcher, CD., Reichman, RC., Klingman, KL., Kuritzkes, DR. Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression. AIDS. Apr 23; 21(7): 813-23 (2007)
Gulick, RM., Su, Z., Flexner, C., Hughes, MD., Skolnik, PR., Wilkin, TJ., Gross, R., Krambrink, A., Coakley, E.,Greaves, WL., Zolopa, A., Reichman, R., Godfrey, C .,Hirsch, M., Kuritzkes, DR. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. J. Infect. Dis. Jul 15; 196(2): 304-12 (2007)
Kuritzkes, DR., Ribaudo, HJ., Squires, KE., Koletar, SL., Santana, J., Riddler, SA., Reichman, R., Shikuma, C., Meyer, WA, 3rd, Klingman, KL., Gulick, RM. Plasma HIV-1 RNA dynamics in antiretroviral-naive subjects receiving either triple-nucleoside or efavirenz-containing regimens: ACTG A5166s. J. Infect. Dis. Apr 15; 195(8): 1169-76 (2007)
Lindsey, JC., Malee, KM., Brouwers, P., Hughes, MD. Neurodevelopmental functioning in HIV-infected infants and young children before and after the introduction of protease inhibitor-based highly active antiretroviral therapy. Pediatrics. Mar; 119(3): e681-93 (2007)
Ribaudo, HJ., Kuritzkes, DR., Gulick, RM. A comparison of three initial antiretroviral AIDS regimens. N. Engl. J. Med. Sep 6; 357(10): 1056-7 (2007)
Tsibris, AM., Kuritzkes, DR. Chemokine antagonists as therapeutics: focus on HIV-1. Annu. Rev. Med. 58: 445-59 (2007)
Wester, C.W., Okezie, O.A., Thomas, A.M., Bussmann, H., Moyo, S., Muzenda, T., Makhema, J., van Widenfelt, E., Musonda, R., Novitsky, V., Gaolathe, T., Ndwapi, N., Essex, M., Kuritzkes, D.R., Degruttola, V., and Marlink, R.G. Higher-than-Expected Rates of Lactic Acidosis Among Highly Active Antiretroviral Therapy–Treated Women in Botswana: Preliminary Results from a Large Randomized Clinical Trial. JAIDS.46:318-322 (2007).
Dinic L, Idigbe OE, Meloni S, Rawizza H, Akande P, Eisen G, Onwujekwe D, Agbaji O, Ani A, Kanki PJ. Sputum smear concentration may misidentify acid-fast bacilli as Mycobacterium tuberculosis (Mtb) in HIV-infected patients. J Acquir Immune Defic Syndr. 2013 Feb 7.
Akanbi MO, Achenbach C, Feinglass J, Taiwo B, Adamu O, Mai P, Agbaji O, Kanki PJ, Murphy R Tuberculosis after One Year of Combination Antiretroviral Therapy in Nigeria. AIDS Res Hum Retroviruses. 2013 Jan 15.
Agbaji O, Thio CL, Meloni S, Graham C, Muazu M, Nimzing L, Idoko J, Sankalé JL, Ekong E, Murphy R, Kanki P, Hawkins C. Impact of Hepatitis C Virus on HIV Response to Antiretroviral Therapy in Nigeria. J Acquir Immune Defic Syndr. 2012 Nov 28.
Thio CL, Smeaton L, Saulynas M, Hwang H, Saravanan S, Kulkarni S, Hakim J, Nyirenda M, Iqbal HS, Lalloo UG, Mehta AS, Hollabaugh K, Campbell TB,Lockman S, Currier JS. Characterization of HIV-HBV co-infection in a multi-national HIV-infected cohort. AIDS. 2012 Oct 22
Shipton, L.K., Wester, C.W., Stock, S., Ndwapi, N., Gaolathe, T., Thior, I., Avalos, A., Moffat, H.J., Mboya J.J., Widenfelt, E., Essex, M., Hughes, M.D., and Shapiro, R.L. Safety and Efficacy of Nevirapine and Efavarinz-Based Antiretroviral Treatment in Adults Treated for TB-HIV Co-Infection in Botswana. Int. J. Tuberc. Lung Dis. 13:360–366 (2009).
Boutwell, C.L., Rowley, C.F., and Essex, M. Reduced Viral Replication Capacity of HIV-1 Subtype C Caused by CTL Escape Mutations in HLA-B57 Epitopes of Capsid Protein. J. Virol. 83:2460–2468 (2009).
Boutwell, C., and Essex, M. Identification of Class I HLA-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses. 23:165-174 (2007).
Lin, N.H., Negusse, D.M., Beroukhim, R., Giguel, F., Lockman, S., Essex, M., and Kuritzkes, D.R. The Design and Validation of a Novel Phenotypic Assay to Determine HIV-1 Coreceptor Usage of Clinical Isolates. J Virol Methods. 169:39–46 (2010).
Lingappa., J.R., Baeten, J.M., Wald, A., Hughes, J.P., Thomas, K.T., Mujugira, A., Mugo, N., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Steward, G.J., Makehma, J., Essex, M., Were, E., Fife, K.H., de Bruyen, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Magaret, A.S., Wang, R.S., Kidoguchi, L., Barnes, L., Ridzon, R., Corey, L., and Celum, C. for the Partners in Prevention HSV/HIV Transmission Study Team. Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet. 375: 824-833. (2010)
MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).
Mine, M., Bedi, K., Maruta, T., Madziva, D., Tau, M., Zana, T., Gaolathe, T., Moyo, S., Seipone, K., Ndwapi, N., Essex, M., and Marlink, R. Quantitation of Human Immunodeficiency Virus Type 1 Viral Load in Plasma Using Reverse Transcriptase Activity Assay at a District Hospital Laboratory in Botswana: A Decentralization Pilot Study. J. Virol. Methods. 159:93–97 (2009).
Novitsky, V., Wang, R., Baca, J., Margolin, L., McLane, MF., Moyo, S., van Widenfelt, E., Makhema, J., Essex, M. Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection. Virology. 2011 Oct 17.
Novitsky, V., Ndung’u, T., Wang, R., Bussmann, H., Chonco, F., Makhema, J., De Gruttola, V., Walker, B.D., Essex, M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS. Apr 18. (2011).
Novitsky, V., Wang, R., Lagakos, S., and Essex, M. HIV-1 Subtype C Phylodynamics in the Global Epidemic. Viruses. 2:33–54 (2010).
Novitsky, V., Wang, R., Margolin, L., Baca, J., Moyo, S., Musonda, R., and Essex, M. Dynamics and Timing of in Vivo Mutations at Gag Residue 242 during Primary HIV-1 Subtype C Infection. Virology. 403:37–46 (2010).
Teeravechyan, S., Essex, M., and Lee, T.H. Conserved Determinants of Enhanced CCR5 Binding in the Human Immunodeficiency Virus Subtype D Envelope Third Variable Loop. AIDS Res. Hum. Retroviruses. 26:481–8 (2010).
Novitsky, V., Lagakos, S., Herzig, M., Bonney, C., Kebaabetswe, L, Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel, E., van Widenfelt, E., Makhema, J., and Essex, M. Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47–59 (2009).
Ojesina, AI., Chaplin, B., Sankale, JL., Murphy, R., Idigbe, E., Adewole, I., Ekong, E., Idoko, J., Kanki, PJ. Interplay of Reverse Transcriptase Inhibitor Therapy and Gag p6 Diversity in HIV Type 1 Subtype G and CRF02_AG. AIDS Res. Hum. Retroviruses. Sep; 24(9): 1167-74 (2008)
Phuphuakrat A, Kraiwong R, Boonarkart C, Lauhakirti D, Lee TH, Auewarakul P. Double-stranded RNA adenosine deaminases enhance expression of human immunodeficiency virus type 1 proteins. J. Virol. Nov;82(21):10864-72. (2008)
Teeravechyan S, Suphaphiphat P, Essex M, Lee TH. Relative concordance of human immunodeficiency virus oligomeric and monomeric envelope in CCR5 coreceptor usage.
Virology. Jan 20;370(2):443-50. Epub 2007 Oct 22. (2008)
Ulenga, NK., Sarr, AD., Thakore-Meloni, S., Sankale, J-L., Eisen, G., Kanki, PJ. Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F. J. Infect. Dis. Aug 15; 198(4): 486-92 (2008)
Ulenga, NK., Sarr, AD., Hamel, D., Sankale, JL., Mboup, S., Kanki, PJ. The Level of APOBEC3G (hA3G)-Related G-to-A Mutations Does Not Correlate with Viral Load in HIV Type 1-Infected Individuals. AIDS Res. Hum. Retroviruses. Oct; 24(10): 1285-90 (2008)
Hu, Z., Hatano, H., Hammond, SP., Smith, D., Wild, M., Gupta, S., Whitcomb, J., Kalayjian, RC., Gripshover, B., Kuritzkes, DR. Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase. JAIDS. Aug 15; 45(5): 494-500 (2007)
Suphaphiphat, P., Essex, M., and Lee, T.H. Mutations in the V3 Stem versus the V3 Crown and C4 Region Have Different Effects on the Binding and Fusion Steps of Human Immunodeficiency Virus Type 1 Gp120 Interaction with the CCR5 Coreceptor. Virology. 360:182-190 (2007).
Montano, M., Rarick, M., Sebastiani, P., Brinkmann, P., Russell, M., Navis, A., Wester, C., Thior, I., and Essex, M. Gene-Expression Profiling of HIV-1 Infection and Perinatal Transmission in Botswana. Genes Immun. 7:298-309 (2006).
Kupka, R., Mugusi, F., Aboud, S., Msamanga, GI., Finkelstein, JL., Spiegelman, D., Fawzi, WW. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes. Am. J. Clin. Nutr. Jun; 87(6): 1802-8 (2008)
Villamor, E., Mugusi, F., Urassa, W., Bosch, RJ., Saathoff, E., Matsumoto, K., Meydani, SN., Fawzi, WW. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J. Infect. Dis. Jun 1; 197(11): 1499-505 (2008)
Drain, PK., Kupka, R., Mugusi, F., Fawzi, WW. Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy. Am. J. Clin. Nutr. Feb; 85(2): 333-45 (2007)
Fawzi, WW., Msamanga, GI., Urassa, W., Hertzmark, E., Petraro, P., Willett, WC., Spiegelman, D. Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N. Engl. J. Med. Apr 5; 356(14): 1423-31 (2007)
Villamor, E., Koulinska, IN., Furtado, J., Baylin, A., Aboud, S., Manji, K., Campos, H., Fawzi, WW. Long-chain n 6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. Am. J. Clin. Nutr. Sep; 86(3): 682-9 (2007)
Chigwedere, P. and Essex, M. AIDS Denialism and Public Health Practice. AIDS Behav. 2010. Epub 8 January 2010.
Mine, M., Bedi, K., Maruta, T., Madziva, D., Tau, M., Zana, T., Gaolathe, T., Moyo, S., Seipone, K., Ndwapi, N., Essex, M., and Marlink, R. Quantitation of Human Immunodeficiency Virus Type 1 Viral Load in Plasma Using Reverse Transcriptase Activity Assay at a District Hospital Laboratory in Botswana: A Decentralization Pilot Study. J. Virol. Methods. 2009.
Bangsberg, DR. The Achilles’ heel of HIV treatment in resource-limited settings. JAIDS. Feb 1 2008.
Chigwedere, P., Seage, G.R. III, Lee, T.H., and Essex, M. Efficacy of Antiretroviral Drugs in Reducing Mother to Child Transmission of HIV in Africa: A Meta-Analysis of Published Clinical Trials. AIDS Res. Hum. Retroviruses. 24(6): 827-37 (2008).
Gruskin, S., Tarantola, D. Universal Access to HIV prevention, treatment and care: assessing the inclusion of human rights in international and national strategic plans. AIDS. Aug; 22 2008.
Gruskin, S., Firestone, R., Maccarthy, S., Ferguson, L. HIV and pregnancy intentions: do services adequately respond to women’s needs? Am. J. Public Health. Oct. 2008.
Kamo, N., Carlson, M., Brennan, RT., Earls, F. Young citizens as health agents: use of drama in promoting community efficacy for HIV/AIDS. Am. J. Public Health. Feb. 2008.
Tarantola, D., Gruskin, S. Pragmatic pathways to universal access: leadership, equity, accountability and partnerships in HIV prevention and care. AIDS. Aug; 22 2008.
Toure, S., Kouadio, B., Seyler, C.,Traore, M., Dakoury-Dogbo, N., Duvignac, J., Diakite, N., Karcher, S. Grundmann, C., Marlink, R., Dabis, F., Anglaret, X. Rapid scaling-up of antiretroviral therapy in 10,000 adults in Cote d’Ivoire: 2-year outcomes and determinants. AIDS. Apr 23 2008.
Gruskin, S., Ferguson, L., Bogecho, D. O. Beyond the numbers: using rights-based perspectives to enhance antiretroviral treatment scale-up. AIDS. Oct; 21 2007.
Tarantola, D., Gruskin, S. New guidance on recommended HIV testing and counselling. Lancet. Jul 21 2007.
Plank RM, Ndubuka NO, Wirth KE, Mwambona JT, Kebaabetswe P, Bassil B, Lesetedi C, Hussein FM, Magetse J, Nkgau M, Makhema J, Mmalane M, Creek T,Powis KM, Shapiro R, Lockman S. A Randomized Trial of Mogen Clamp versus Plastibell for Neonatal Male Circumcision in Botswana. J Acquir Immune Defic Syndr. 2013 Jan 10
Novitsky, V., Essex, M. Using HIV viral load to guide treatment-for-prevention interventions. Curr Opin HIV AIDS. 2012 Jan 16.
Lockman, S., Sax, P. Treatment-for-prevention: clinical considerations. Curr Opin HIV AIDS. 2012 Jan 5.
Jayeoba, O., Dryden-Peterson, S., Okui, L., Smeaton, L., Magetse, J., Makori, L., Modikwa, V., Mogodi, M., Plank, R., Lockman, S. Acceptability of Male Circumcision Among Adolescent Boys and their Parents, Botswana. AIDS Behav. Mar 25 2011.
Cohen, M.S., Chen, Y.Q., McCauley, M., Gamble, T., Hosseinipour, M.C., Kumarasamy, N., Hakim, J.G., Kumwenda, J., Grinsztejn, B., Pilotto, J.H., Godbole, S.V., Mehendale, S., Chariyalertsak, S., Santos, B.R., Mayer, K.H., Hoffman, I.F., Eshleman, S.H., Piwowar-Manning, E., Wang, L., Makhema, J., Mills, L.A., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T.E., Nielsen-Saines, K., Celentano, D., Essex, M., Fleming, T.R.; the HPTN 052 Study Team. Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med. 2011 Jul 18.
Celum, C., Wald, A., Lingappa, J.R., Magaret, A.S., Wang, R.S., Mugo, N., Mujugira, A., Baeten, J.M., Mullins, J.I., Hughes, J.P., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were, E., Fife, K.H., de Bruyn, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Stevens, W., Campbell, M.S., Thomas, K.K., Coombs, R.W., Morrow, R., Whittington, W.L.H., McElrath, M.J., Barnes, L., Ridzon, R., and Corey, L., for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. N Engl J Med. 362:427 (2010).
Lingappa, J.R., Hughes, J.P., Wang, R.S., Baeten, J.M., Celum, C., Gray, G.E., Stevens, W., Donnell, D., Campbell, M.S., Farquhar, C., Essex, M., Mullins, J.I., Coombs, R.W., Rees, H., Corey, L., and Wald, A. for the Partners in Prevention HSV/HIV Transmission Study Team. Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk. PLoS One.5:e12598. (2010)
Novitsky, V., Wang, R., Bussmann, H., Lockman, S., Baum, M., Shapiro, R., Thior, I., Wester, C., Wester, C.W., Ogwu, A., Asmelash, A., Musonda, R., Campa, A., Moyo, S., van Widenfelt, E., Mine, M., Moffat, C., Mmalane, M., Makhema, J., Marlink, R., Gilbert, P., Seage, G.R. 3rd, DeGruttola, V., and Essex, M. HIV-1 Subtype C Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission. PloS One. 5:e10148 (2010).
Plank, R.M., Makhema, J., Kebaabetswe, P., Hussein, F., Leseidi, C., Halperinm D., Bassil, B., Shapiro, R., Lockman, S. Acceptability of infant male circumcision as part of HIV prevention and male reporductive health efforts in Gaborone, Botswana, and surrounding areas. AIDS Behav. Oct;14(5):1198-202. (2010)
Shapiro, R., Hughes, M., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Snowden, W., Martinez-Tristani, M., Mazhani, L., Essex, M. Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010).
Lingappa, J.R., Kahle E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were E., Fife K., deBruyn, G., Gray, G., McIntyre, J., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Coombs, R.W., Morrow, R., Whittington, W., Corey, L., Wald, A., and Celum, C., for the Partners HSV-2/HIV-1 Transmission Study Team. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE. 4:e5272 (2009).
Earls, F., Raviola, GJ., Carlson, M. Promoting child and adolescent mental health in the context of the HIV/AIDS pandemic with a focus on sub-Saharan Africa. J. Child Psychol. Psychiatry. Mar; 49(3): 295-312 (2008)
Lagakos, SW., Gable, AR. Challenges to HIV prevention–seeking effective measures in the absence of a vaccine. N. Engl. J. Med. Apr 10; 358(15): 1543-5 (2008)
Prevention of Mother-to-Child Transmission (PMTCT)
Powis KM, McElrath TF, Hughes MD, Ogwu A, Souda S, Datwyler SA, von Widenfelt E, Moyo S, Nádas M, Makhema J, Machakaire E, Lockman S, Essex M, Shapiro RL. High Viral Load and Elevated Angiogenic Markers Associated with Increased Risk of Preeclampsia among Women Initiating Highly Active Antiretroviral Therapy (HAART) in Pregnancy in the Mma Bana Study, Botswana. J Acquir Immune Defic Syndr. 2013 Jan 22
Mazzeo CI, Flanagan EH, Bobrow EA, Pitter CS, Marlink R. How the global call for elimination of pediatric HIV can support HIV-positive women to achieve their pregnancy intentions. Reprod Health Matters. 2012 Dec 20
Sawe F, Lockman S. To B or Not to B? That Is the Question, for Global Mother-to-Child HIV-1 Transmission Prevention Programs.Clin Infect Dis. 2012 Nov 30.
Shapiro RL., Rossi S., Ogwu A., Moss M., Leidner J., Moffat C., Lockman S., Moyo S., Makhema J., Essex M., Capparelli E. Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk, in the Mma Bana Study, Botswana. Antivir Ther. 2012 Nov 26.
Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwu A, Lockman S, Powis K, Dryden-Peterson S, Creek T, Jimbo W, Madidimalo T, Makhema J, Essex M, Shapiro RL. Highly Active Antiretroviral Therapy and Adverse Birth Outcomes Among HIV-Infected Women in Botswana. J Infect Dis. 2012 Oct 12
Shapiro, Roger L.; Souda, Sajini; Parekh, Natasha; Binda, Kelebogile; Kayembe, Mukendi; Lockman, Shahin; Svab, Petr; Babitseng, Orphinah; Powis, Kathleen; Jimbo, William; Creek, Tracy; Makhema, Joseph; Essex, Max; Roberts, Drucilla J.; Vermund, Sten H. High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana.PLoS ONE. 2012;7(2):e31580. Epub 2012 Feb 22.
Becquet R, Marston M, Dabis F, Moulton LH, Gray G, Coovadia HM, Essex M, Ekouevi DK, Jackson D, Coutsoudis A, Kilewo C, Leroy V, Wiktor SZ, Nduati R, Msellati P, Zaba B, Ghys PD, Newell ML; UNAIDS Child Survival Group.Children who acquire HIV infection perinatally are at higher risk of early death than those acquiring infection through breastmilk: a meta-analysis.PLoS ONE. 2012;7(2):e28510. Epub 2012 Feb 23.
Dong, B.J., Zheng, Y., Hughes, M.D., Frymoyer, A., Verotta, D., Lizak, P., Sawe, F., Currier, J.S., Lockman, S., Aweeka, F.T.; for the AIDS Clinical Trials Group Study 5208 Team. Nevirapine (NVP) pharmacokinetics (PK) and risk of rash and hepatitis among HIV-infected Sub-Saharan African Women. AIDS. 2012 Feb 1.
Rossenkhan, R., Novitsky, V., Sebunya, T.K., Leidner, J., Hagan, J.E., Moyo, S., Smeaton, L., Lockman, S., Musonda, R., Ndung’u, T., Gaseitsiwe, S., Thior, I., Mmalane, M., Makhema, J., Essex, M., Shapiro, R. Infant Feeding Practices were not Associated with Breast Milk HIV-1 RNA Levels in a Randomized Clinical Trial in Botswana. AIDS Behav. 2011 Sep 7.
Ciaranello, A.L., Lockman, S., Freedberg, K.A., Hughes, M., Chu, J., Currier, J., Wood, R., Holmes, C.B., Pillay, S., Conradie, F., McIntyre, J., Losina, E., Walensky, R.P.; for the CEPAC-International and OCTANE Investigators. First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effictiveness anaylysis of the OCTANE trial. AIDS. Feb 20.25(4):479-492. (2011)
Dryden-Peterson, S., Jayeoba, O., Hughes, M.D., Jibril, H., Keapoletswe, K., Tlale, J., Modise, T.A., Asmelash, A., Moyo, S., van Widenfel,t E., Makhema, J., Essex, M., Shapiro, R.L., Lockman, S. Highly Active Antiretroviral Therapy versus Zidovudine for Prevention of Mother-to-Child Transmission in a Programmatic Setting, Botswana. J Acquir Immune Defic Syndr. 2011 Jul 22. [Epub ahead of print]
Powis, K.M., Kitch, D., Ogwu, A., Hughes, M.D., Lockman, S., Leidner, J., van Widenfelt, E., Moffat, C., Moyo, S., Makhema, J., Essex, M., Shapiro, R.L. Increased Risk of Preterm Delivery Among HIV-Infected Women Randomized to Protease Versus Nucleoside Reverse Transcriptase Inhibitor-Based HAART During Pregnancy. J Infect Dis. 2011 Aug;204(4):506-14.
Powis, K.M., Smeaton, L., Ogwu, A., Lockman, S. Dryden-Peterson, S., van Widenfelt, E., Leidner, J., Makhema, J., Essex, M., and Shapiro, R.L. Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. JAIDS. 1:56(2):131–8. (2011)
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J. Acquir. Immune Defic. Syndr. 54:102–6 (2010).
Lockman, S., Hughes, M.D., McIntyre, J., Zheng, Y., Chipato, T., Conradie, F., Sawe, F., Asmelash, A., Hosseinipour, M.C., Mohapi, L., Stringer, E., Mngqibisa, R., Siika, A., Atwine, D., Hakim, J., Shaffer, D., Kanyama, C., Wools-Kaloustian, K., Salata, R.A., Hogg, E., Alston-Smith, B., Walawander, A., Purcelle-Smith, E., Eshleman, S., Rooney, J., Rahim, S., Mellors, J.W., Schooley, R.T., Currier, J.S.; OCTANE A5208 Study Team. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med. Oct 14; 363(16):1499-509. (2010).
MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).
Shapiro, R., Hughes, M., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Snowden, W., Martinez-Tristani, M., Mazhani, L., Essex, M. Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010).
Shapiro, R.L., Lockman, S. Mortality among HIV-exposed infants: the first and final frontier. Clin Infect Dis. Feb 1;50(3):445-7. (2010)
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J Acquir Immune Defic Syndr. Epub 27 October 2009.
Lockman, S., Creek, T. Acute maternal HIV infection during pregnancy and breast-feeding: substantial risk to infants. J Infect Dis. Sep 1;200(5):667-9. (2009)
Rossenkhan, R., Ndung’u, T., Sebunya, T., Hagan, J., Shapiro, R., Novitsky, V., Moyo, S.M., Thior, I., Lockman, S., Mitchell, R., Kim, S., Musonda, R., van Widenfelt, E., Makhema, J., and Essex, M. Temporal Reduction of HIV Type 1 Viral Load in Breast Milk by Single-Dose Nevirapine during Prevention of MTCT. AIDS Res. Hum. Retroviruses. 25:1261–4 (2009).
Shapiro, R.L., Smeaton, L., Lockman, S., Thior, I., Rossenkahn, R., Wester, C., Stevens, L., Moffat, C., Arimi, P., Ndase, P., Asmelash, A., Leidner, J., Novitsky, V., Makhema, J., and Essex, M. Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana. J. Infect. Dis. 199:414–418 (2009).
Bae, W.H., Wester, C., Shapiro, R.L., Lockman, S., Onyait, K., Thior, I., and Essex, M. Hematologic and Hepatic Toxicities Associated with Antenatal and Postnatal Exposures to Maternal HAART in Infants in Botswana. AIDS. 22:1633–1640 (2008).
Chigwedere, P., Seage, G.R. III, Lee, T.H., and Essex, M. Efficacy of Antiretroviral Drugs in Reducing Mother to Child Transmission of HIV in Africa: A Meta-Analysis of Published Clinical Trials. AIDS Res. Hum. Retroviruses. 24(6): 827-37 (2008).
Zhang, P., Lagakos, SW. Analysis of time to a silent event whose occurrence is monitored with error, with application to mother-to-child HIV transmission. Stat. Med. Oct 15; 27(23): 4637-46 (2008)
Jourdain, G., Mary, JY., Coeur, SL., Ngo-Giang-Huong, N., Yuthavisuthi, P., Limtrakul, A., Traisathit, P., McIntosh, K., Lallemant, M. Risk Factors for In Utero or Intrapartum Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 in Thailand. J.Infect. Dis. Dec 1; 196(11): 1629-36 (2007)
Kantarci, S., Koulinska, IN., Aboud, S., Fawzi, WW., Villamor, E. Subclinical mastitis, cell-associated HIV-1 shedding in breast milk, and breast-feeding transmission of HIV-1. JAIDS. Dec 15; 46(5): 651-4 (2007)
Lockman, S., McIntyre, JA. Reduction of HIV-1 drug resistance after intrapartum single-dose nevirapine. Lancet. Nov 17; 370(9600):1668-70 (2007)
Lockman, S., Shapiro, R.L., Smeaton, L.M., Wester, C., Thior, I., Stevens, L., Chand, F., Makhema, J., Moffat, C., Asmelash, A., Ndase, P., Arimi, P., van Widenfelt, E., Mazhani, L., Novitsky, V., Lagakos, S., and Essex, M. Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine. N. Engl. J. Med. 356:135-147 (2007).
Shapiro, R.L., Lockman, S., Kim, S., Smeaton, L., Rahkola, J.T., Thior, I., Wester, C., Moffat, C., Arimi, P., Ndase, P., Asmelash, A., Stevens, L., Montano, M., Makhema, J., Essex, M., and Janoff, E.N. Infant Morbidity, Mortality, and Breast Milk Immunologic Profiles among Breastfeeding HIV-Infected and HIV-Uninfected Women in Botswana. J. Infect. Dis. 196:562-569 (2007).
Thior, I., Gabaitiri, L., Grimes, J., Shapiro, R., Lockman, S., Kim, S., Kebaabetswe, P., Garmey, E., Montano, M., Peter, T., Chang, S.Y., Marlink, R., and Essex M. Voluntary Counseling and Testing among Post-Partum Women in Botswana. Patient Educ. Couns. 65:296-302 (2007).
Koulinska, I.N., Villamor, E., Chaplin, B. Msamanga, G., Fawzi, W., Renjifo, B., and Essex, M. Transmission of Cell-Free and Cell-Associated HIV-1 Through Breast-Feeding. J. Acquir. Immune Defic. Syndr. 41:93-99 (2006).
Montano, M., Rarick, M., Sebastiani, P., Brinkmann, P., Russell, M., Navis, A., Wester, C., Thior, I., and Essex, M. Gene-Expression Profiling of HIV-1 Infection and Perinatal Transmission in Botswana. Genes Immun. 7:298-309 (2006).
Thior, I., Lockman, S., Smeaton, L.M., Shapiro, R.L., Wester, C., Heymann, S.J., Gilbert, P.B., Stevens, L., Peter, T., Kim, S., van Widenfelt, E., Moffat, C., Ndase, P., Arimi, P., Kebaabetswe, P., Mazonde, P., Makhema, J., McIntosh, K., Novitsky, V., Lee, T.H., Marlink, R., Lagakos, S., and Essex, M., for the Mashi Study Team. Breastfeeding Plus Infant Zidovudine Prophylaxis for 6 Months vs Formula Feeding Plus Infant Zidovudine for 1 Month to Reduce Mother-to-Child HIV Transmission in Botswana. A Randomized Trial: The Mashi Study. JAMA. 296:794-805 (2006).
Firnhaber, C., Evans, D., Friedman-Khalili, R., Willliams, S., Michelow, P., Matlhagela, K., Wester, C., Grinsztejn, B., Lockman, S. Seroprevalence of HPV vaccine types 6, 11, 16 and 18 in HIV-infected women from South Africa, Brazil and Botswana. J Clin Virol. 2011 Sep 9.
Novitsky, V., Wang, R., Margolin, L., Baca, J., Moyo, S., Musonda, R., and Essex, M. Dynamics and Timing of in Vivo Mutations at Gag Residue 242 during Primary HIV-1 Subtype C Infection. Virology. 403:37–46 (2010).
Novitsky, V., Lagakos, S., Herzig, M., Bonney, C., Kebaabetswe, L, Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel, E., van Widenfelt, E., Makhema, J., and Essex, M. Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47–59 (2009).
Rodriguez, SK., Sarr, AD., MacNeil, A., Thakore-Meloni, S., Gueye-Ndiaye, A., Traore, I., Dia, MC., Mboup, S., Kanki, PJ. Comparison of heterologous neutralizing antibody responses of human immunodeficiency virus type 1 (HIV-1)- and HIV-2-infected Senegalese patients: distinct patterns of breadth and magnitude distinguish HIV-1 and HIV-2 infections. J. Virol. May; 81(10): 5331-8 (2007)